Instituto de Biomedicina de Sevilla
23:59| Título | Predoctoral (FPI) position in Neuroscience |
|---|---|
| Limit date | 31/08/2023 23:59 |
| Referencia | Predoc-MPS-1-2023 |
| Entidad | Instituto de Biomedicina de Sevilla |
Predoctoral (FPI) position in Neuroscience
Molecular Physiology of the Synapse Laboratory
Institute of Biomedicine of Seville
(IBiS, HUVR/CSIC/Universidad de Sevilla)
Seville (Spain)
Molecular mechanisms of CSPalpha/DNAJC5 in Kufs disease/CLN4 and in the maintenance of presynaptic terminals (MoMCSP)
Mutations in the DNAJC5 gene, which encodes the synaptic vesicle protein Cysteine String Protein alpha (CSPalpha/DNAJC5), have been identified as the cause of adult-onset autosomal dominant neuronal ceroid lipofuscinosis (NCLs) Kufs disease/CLN4. This devastating neurodegenerative disease primarily affects young adults. Recent discoveries have highlighted that DNAJC5 mutations lead to lipofuscinosis in neurons in vivo through a gain of a novel, toxic function of CSPalpha/DNAJC5, rather than a mere lack of CSPalpha/DNAJC5 (López-Begines et al., bioRxiv 2023). Conversely, knock-out mice lacking CSPalpha/DNAJC5 exhibit presynaptic degeneration, especially in neurons with high-firing rates. Over the past years, our laboratory has made significant progress by generating novel cell lines and mouse models and conducting unbiased proteomics and single-cell transcriptomic analyses. These endeavors have unveiled unexpected molecular scenarios shedding light on the physiological role of CSPalpha/DNAJC5 and the underlying mechanisms behind the pathology associated with its mutations or absence.
We are currently seeking a highly motivated candidate to embark on an international PhD project aimed at investigating the intricate molecular mechanisms underlying lipofuscinosis and presynaptic degeneration. This research will employ multidisciplinary approaches, leveraging the cutting-edge tools and knowledge developed in our lab. Contract supports four years’ salary and research stays abroad at other labs at USA or Europe.
More details here: https://shorturl.at/euMQ8
Candidates should email CV and contact information for 3 references to Dr. Rafael Fernández-Chacón (sinapsis-ibis@us.es).
Email subject: Predoc-MPS-1-2023.
Deadline: August 31st, 2023
(but better if applications are receive as soon as possible)
