Cód. SSPA: IBiS-E-05
The “Liver Physiopathology” laboratory seeks to understand the contribution of dysregulated inflammatory cytokines and metabolism to liver and metabolic disorders, in particular focusing on metabolic dysfunction-associated fatty liver disease (MAFLD). Our lab is interested in the molecular mechanisms that control steatosis and inflammation-driven chronic liver diseases development.
Research lines:
- Recent advances in metabolomics have revealed that mitochondrial metabolism is reprogrammable and has emerged as a common mechanism that underlies the progression of the disease. The team aims to understand how mitochondria dysfunction can contribute to disease initiation and progression affecting metabolic processes involved in liver pathophysiology. Understanding of how intracellular metabolic changes lead to disease, could offer new methods for diagnosis and could also complement or even replace current therapeutic approaches for liver diseases.
- Increasing evidence point IL-6 family of cytokines as essential players in the regulation of metabolic homeostasis as well as in the pathophysiology liver disorders and inflammation; thus, making them attractive therapeutic targets.
The team has made fundamental discoveries on IL-6 family of cytokines in the regulation of metabolic homeostasis as well as in the pathophysiology of liver disorders, with special attention in the MASLD and inflammatory diseases. The team aims to investigate the role of these cytokines as a target in metabolic and inflammatory diseases.
For those purposes we use relevant animal models of the disease, clinical samples and apply state-of-the-art analytical molecular technologies.
Research grants: FORT23/00008; PI23/01351; PID2022-143034OBI00; PID2019-110587RB-I00; PY18-4775; Intramural CSIC 2018; PI16/017971
Networks: PTI (Plataforma Temática Interdisciplinar) Salud Global (CSIC); Metabocancer; CIBER Enfermedades hepáticas y digestivas (CIBERehd).
