Mechanisms of Neuronal Maintenance

Alberto Pascual Bravo
Alberto Pascual Bravo
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla

Laboratory: 109

Alberto Pascual Bravo

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  1. Group members
  2. Research areas
  3. Publications

Group: Mechanisms of Neuronal Maintenance

Group members Mechanisms of Neuronal Maintenance
  • Álvarez Vergara, Mª Isabel.Lda. en Biomedicina básica y experimental
  • Capelo Carrasco,, Nicolás.Ldo. en Farmacia, Óptica y Optometría
  • Pascual Bravo, Alberto.PhD in Biology. Staff Scientist (CSIC).
  • Rosales Nieves, Alicia Elena.Dra. en Biología. Investigadora Juan de la Cierva.

Research areas

Our group's work is focused on three main topics:

Elucidation of the mechanisms underlying the positive effects of trophic factors on specific neuronal populations.
In particular, we are characterizing the molecular players involved in the maintenance by GDNF of specific catecholaminergic populations in the central and peripheral nervous systems. By using genetically modified animals, proteomic, genomic and imaging techniques, we are identifying the neuroprotective actions of trophic factors that operate both at the level of the terminals and the soma of these neurons.

Neuronal adaptations to acute changes in oxygen concentration.
We are also studying neuronal adaptations to acute decreases in the levels of available oxygen. These mechanisms will be crucial in determining cellular fate after a hypoxic or ischemic insult. We have used proteomic techniques to study how the proteome evolves in cellular lines and in animals to respond to a physiologically brief episode of hypoxia. The underlying hypothesis is that all cells, and in particular neurons, have specific acute molecular responses to achieve homeostasis under oxygen deprivation. More recently we are investigating the effect of hypoxia on the progression of several neurodegenerative diseases.

Analysis of biological and biomedical images using System Biology methods.
Dr. Luis M. Escudero leads an independent research line combining computerized image analysis and Network Science to investigate different biological and biomedical questions. Extracting the defining signature of complex images we obtain objective and quantitative information that help to interpret biological processes in development and disease. Our research interests span from the morphogenesis of the fly wing to human neuromuscular diseases.

International Journals
Perez-Martinez, A; Ferreras, C; Pascual, A; Gonzalez-Vicent, M; Alonso, L; Badell, I; Navarro, JMF; Regueiro, A; Plaza, M; Hurtado, JMP; Benito, A; Belendez, C; Couselo, JM; Fuster, JL; Diaz-Almiron, M; Bueno, D; Mozo, Y; Marsal, J; Lopez, AG; Sisinni, L; de Heredia, CD; Diaz, MA
Haploidentical transplantation in high-risk pediatric leukemia: A retrospective comparative analysis on behalf of the Spanish working Group for bone marrow transplantation in children (GETMON) and the Spanish Grupo for hematopoietic transplantation (GETH)
Harasztosi, C; Wolter, S; Gutsche, K; Duran-Alonso, MB; Lopez-Hernandez, I; Pascual, A; Lopez-Barneo, J; Knipper, M; Ruttiger, L; Schimmang, T
Differential deletion of GDNF in the auditory system leads to altered sound responsiveness
Fernandez-Cuenca, F; Lopez-Cerero, L; Cabot, G; Oliver, A; Lopez-Mendez, J; Recacha, E; Portillo, I; Rodriguez-Bano, J; Pascual, A
Nosocomial outbreak linked to a flexible gastrointestinal endoscope contaminated with an amikacin-resistant ST17 clone of Pseudomonas aeruginosa
Rodriguez-Bano, J; Perez-Moreno, MA; Penalva, G; Garnacho-Montero, J; Pinto, C; Salcedo, I; Fernandez-Urrusuno, R; Neth, O; Gil-Navarro, MV; Perez-Milena, A; Sierra, R; Estella, A; Lupion, C; Irastorza, A; Marquez, JL; Pascual, A; Rojo-Martin, MD; Perez-Lozano, MJ; Valencia-Martin, R; Cisneros, JM
Outcomes of the PIRASOA programme, an antimicrobial stewardship programme implemented in hospitals of the Public Health System of Andalusia, Spain: an ecologic study of time-trend analysis
Canton, R; Oliver, A; Alos, JI; de Benito, N; Bou, G; Campos, J; Calvo, J; Canut, A; Castillo, J; Cercenado, E; Dominguez, MA; Fernandez-Cuenca, F; Guinea, J; Larrosa, N; Linares, J; Lopez-Cerero, L; Lopez-Navas, A; Marco, F; Mirelis, B; Moreno-Romo, MA; Morosini, MI; Navarro, F; Oteo, J; Pascual, A; Perez-Trallero, E; Perez-Vazquez, M; Soriano, A; Torres, C; Vila, J; Martinez-Martinez, L
Recommendations of the Spanish Antibiogram Committee (COESANT) for selecting antimicrobial agents and concentrations for in vitro susceptibility studies using automated systems
Fernandez-Cuenca, F; Perez-Palacios, P; Galan-Sanchez, F; Lopez-Cerero, L; Lopez-Hernandez, I; Rojas, RL; Arca-Suarez, J; Diaz-de Alba, P; Iglesias, MR; Pascual, A
First identification of bla(NDM-1) carbapenemase in bla(OXA-94)-producing Acinetobacter baumannii ST85 in Spain
Lopez-Hernandez, I; Barrionuevo, AG; de Alba, PD; Clavijo, E; Pascual, A
Characterization of NDM-1-and CMH-3-producing Enterobacter cloacae complex ST932 in a patient transferred from Ukraine to Spain
Perez-Palacios, P; Lopez-Cerero, L; Lupion, C; Pascual, A
Assessment of a semi-automated enrichment system (Uroquattro HB&L) for detection of faecal carriers of ESBL-/AmpC-producing Enterobacterales
Fernandez-Cuenca, F; Martinez-Martinez, L; Pascual, A
Evolution of the antimicrobial resistance rates in clinical isolates of Pseudomonas aeruginosa causing invasive infections in the south of Spain
Blasco, L; Ambroa, A; Trastoy, R; Bleriot, I; Moscoso, M; Fernandez-Garcia, L; Perez-Nadales, E; Fernandez-Cuenca, F; Torre-Cisneros, J; Oteo-Iglesias, J; Oliver, A; Canton, R; Kidd, T; Navarro, F; Miro, E; Pascual, A; Bou, G; Martinez-Martinez, L; Tomas, M
In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens
Vicente-Munuera, P; Gomez-Galvez, P; Tetley, RJ; Forja, C; Tagua, A; Letran, M; Tozluoglu, M; Mao, YL; Escudero, LM
EpiGraph: an open-source platform to quantify epithelial organization
Rodriguez-Bano, J; Palacios-Baena, ZR; Pascual, A
Assessing the Ecological Benefit of Antibiotic De-escalation Strategies to Elaborate Evidence-Based Recommendations Reply
Delgado-Valverde, M; Conejo, MD; Serrano, L; Fernandez-Cuenca, F; Pascual, A
Activity of cefiderocol against high-risk clones of multidrug-resistant Enterobacterales, Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia
Portillo-Calderon, I; Ortiz-Padilla, M; Rodriguez-Martinez, JM; de Gregorio-Iaria, B; Blazquez, J; Rodriguez-Bano, J; Pascual, A; Docobo-Perez, F
Contribution of hypermutation to fosfomycin heteroresistance in Escherichia coli
Ortiz-Padilla, M; Diaz-Diaz, S; Machuca, J; Tejada-Gonzalez, A; Recacha, E; Docobo-Perez, F; Pascual, A; Rodriguez-Martinez, JM
Role of low-level quinolone resistance in generating tolerance in Escherichia coli under therapeutic concentrations of ciprofloxacin
Bleriot, I; Trastoy, R; Blasco, L; Fernandez-Cuenca, F; Ambroa, A; Fernandez-Garcia, L; Perez-Nadales, E; Torre-Cisneros, J; Oteo-Iglesias, J; Navarro, F; Miro, E; Pascual, A; Bou, G; Martinez-Martinez, L; Tomas, M
Genomic analysis of 40 prophages located in the genomes of 16 carbapenemase-producing clinical strains of Klebsiella pneumoniae
Perez-Nadales, E; Gutierrez-Gutierrez, B; Natera, AM; Abdala, E; Magalhaes, MR; Mularoni, A; Monaco, F; Pierrotti, LC; Freire, MP; Iyer, RN; Steinke, SM; Calvi, EG; Tumbarello, M; Falcone, M; Fernandez-Ruiz, M; Costa-Mateo, JM; Rana, MM; Strabelli, TMV; Paul, M; Farinas, MC; Clemente, WT; Roilides, E; Munoz, P; Dewispelaere, L; Loeches, B; Lowman, W; Tan, BH; Escudero-Sanchez, R; Bodro, M; Grossi, PA; Soldani, F; Gunseren, F; Nestorova, N; Pascual, A; Martinez-Martinez, L; Aguado, JM; Rodriguez-Bano, J; Torre-Cisneros, J; Song, ATW; Andraus, W; D'Albuquerque, LAC; David-Neto, E; de Paula, FJ; Rossi, F; Ostrander, D; Avery, R; Rizzi, M; Losito, AR; Raffaelli, F; Del Giacomo, P; Tiseo, G; Lora-Tamayo, J; San-Juan, R; Gracia-Ahufinger, I; Caston, J; Ruiz, YA; Altman, DR; Campos, SV; Bar-Sinai, N; Koppel, F; Almajano, FAD; Rico, CG; Martinez, MF; Mourao, PHO; Neves, FA; Ferreira, J; Pyrpasopoulou, A; Iosifidis, E; Romiopoulos, I; Minero, MV; Sanchez-Carrillo, C; Lardo, S; Coussement, J; Dodemont, M; Jiayun, K; Martin-Davila, P; Fortun, J; Almela, M; Moreno, A; Linares, L; Gasperina, DD; Balsamo, ML; Rovelli, C; Concia, E; Chiesi, S; Salerno, DN; Ogunc, D; Pilmis, B; Seminari, EM; Carratala, J; Dominguez, A; Cordero, E; Lepe, JA; Montejo, M; de Lucas, EM; Eriksson, BM; van Delden, C; Manuel, O; Arslan, H; Tufan, ZK; Kazak, E; David, M; Lease, E; Cornaglia, G; Akova, M
Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: The impact of cytomegalovirus disease and lymphopenia
Canizales, JT; Ferreras, C; Pascual, A; Alonso, L; Regueiro, A; Plaza, M; Hurtado, JMP; Benito, A; Couselo, JM; Fuster, JL; Diaz-Almiron, M; Bueno, D; Mozo, Y; Lopez, AG; Vicario, JL; Balas, A; Sisinni, L; de Heredia, CD; Perez-Martinez, A
Haploidentical transplantation in pediatric non-malignant diseases: A retrospective analysis on behalf of the Spanish Group for Hematopoietic Transplantation (GETH)
Lopez-Hernandez, I; Delgado-Valverde, M; Fernandez-Cuenca, F; Lopez-Cerero, L; Machuca, J; Pascual, L
Carbapenemase-Producing Gram-Negative Bacteria in Andalusia, Spain, 2014-2018
Martin-Gutierrez, G; Docobo-Perez, F; Rodriguez-Martinez, JM; Pascual, A; Blazquez, J; Rodriguez-Beltran, J
Detection of Low-Level Fosfomycin-Resistant Variants by Decreasing Glucose-6-Phosphate Concentration in Fosfomycin Susceptibility Determination
Bleriot, I; Blasco, L; Delgado-Valverde, M; Gual-de-Torrella, A; Ambroa, A; Fernandez-Garcia, L; Lopez, M; Oteo-Iglesias, J; Wood, TK; Pascual, A; Bou, G; Fernandez-Cuenca, F; Tomas, M
Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains ofKlebsiella pneumoniaeProducers of Carbapenemase: Role of New Type II Toxin-Antitoxin System, PemIK
Sobrino V, Annese V, Navarro-Guerrero E, Platero-Luengo A, Pardal R
The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system.
Cell Mol Life Sci.
Harasztosi C, Wolter S, Gutsche K, Durán-Alonso MB, López-Hernández I, Pascual A, López-Barneo J, Knipper M, Rüttiger L, Schimmang T
Differential deletion of GDNF in the auditory system leads to altered sound responsiveness.
J Neurosci Res.
Sobrino V, Annese V, Pardal R
Progenitor Cell Heterogeneity in the Adult Carotid Body Germinal Niche.
Adv Exp Med Biol
Dong C, Helton ES, Zhou P, Ouyang X, d'Anglemont de Tassigny X, Pascual A, López-Barneo J, Ubogu EE.
Glial-derived neurotrophic factor is essential for blood-nerve barrier functional recovery in an experimental murine model of traumatic peripheral neuropathy.
Tissue Barriers.
Gómez-Gálvez P, Vicente-Munuera P, Tagua A, Forja C, Castro AM, Letrán M, Valencia-Expósito A, Grima C, Bermúdez-Gallardo M, Serrano-Pérez-Higueras Ó, Cavodeassi F, Sotillos S, Martín-Bermudo MD, Márquez A, Buceta J, Escudero LM.
Scutoids are a geometrical solution to three-dimensional packing of epithelia.
Nat Commun.
Ortega-de San Luis C, Sánchez-García MA, Nieto-González JL, García-Junco-Clemente P, Montero-Sánchez A, Fernández-Chacón R, Pascual A.
Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits.
Aging Cell.
Piñol-Jurado P, Suárez-Calvet X, Fernández-Simón E, Gallardo E, de la Oliva N, Martínez-Muriana A, Gómez-Gálvez P, Escudero LM, Pérez-Peiró M, Wollin L, de Luna N, Navarro X, Illa I, Díaz-Manera J.
Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy
Cell Death Dis.
Sánchez-Gutiérrez D, Sáez A, Gómez-Gálvez P, Paradas C, Escudero LM.
Rules of tissue packing involving different cell types: human muscle organization
Sci Rep
Serrano-Pozo A, Sánchez-García MA, Heras-Garvín A, March-Díaz R, Navarro V, Vizuete M, López-Barneo J, Vitorica J, Pascual A.
Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo
PLoS One