Mechanisms of Neuronal Maintenance

Alberto Pascual Bravo
Alberto Pascual Bravo
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla

Laboratory: 109

Alberto Pascual Bravo

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  1. Group members
  2. Research areas
  3. Publications

Group: Mechanisms of Neuronal Maintenance

Group members Mechanisms of Neuronal Maintenance
  • Castro Cañal, Ana M.FP2. Técnico de Anatomía Patológica.
  • Forja Barbosa, Cristina.Grado Ingeniería de la Salud
  • Lara Ureña, Nieves.Lda. Biotecnología. Predoctoral.
  • March Díaz, Rosana.PhD in Biology. Post-doctoral fellow Sara Borrell.
  • Montero Sánchez, Adoración.Clinical Analysis Laboratory Technician (FP2).
  • Ortega de San Luis, Clara.Degree in Biology. PhD student.
  • Pascual Bravo, Alberto.PhD in Biology. Staff Scientist (CSIC).
  • Rosales Nieves, Alicia Elena.Dra. en Biología. Investigadora Juan de la Cierva.
  • Sánchez García, Manuel.Degree in Biology. PhD student
  • Vargas Padilla , María Victoria.Técnico Superior de Diagnóstico Clínico

Research areas

Our group's work is focused on three main topics:

Elucidation of the mechanisms underlying the positive effects of trophic factors on specific neuronal populations.
In particular, we are characterizing the molecular players involved in the maintenance by GDNF of specific catecholaminergic populations in the central and peripheral nervous systems. By using genetically modified animals, proteomic, genomic and imaging techniques, we are identifying the neuroprotective actions of trophic factors that operate both at the level of the terminals and the soma of these neurons.

Neuronal adaptations to acute changes in oxygen concentration.
We are also studying neuronal adaptations to acute decreases in the levels of available oxygen. These mechanisms will be crucial in determining cellular fate after a hypoxic or ischemic insult. We have used proteomic techniques to study how the proteome evolves in cellular lines and in animals to respond to a physiologically brief episode of hypoxia. The underlying hypothesis is that all cells, and in particular neurons, have specific acute molecular responses to achieve homeostasis under oxygen deprivation. More recently we are investigating the effect of hypoxia on the progression of several neurodegenerative diseases.

Analysis of biological and biomedical images using System Biology methods.
Dr. Luis M. Escudero leads an independent research line combining computerized image analysis and Network Science to investigate different biological and biomedical questions. Extracting the defining signature of complex images we obtain objective and quantitative information that help to interpret biological processes in development and disease. Our research interests span from the morphogenesis of the fly wing to human neuromuscular diseases.