Liver, Digestive and Inflammatory Diseases

Molecular neuroimmunoendocrinology

Antonio Carrillo Vico
Antonio Carrillo Vico
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla
Laboratory: 210
Juan Miguel Guerrero Montávez
Juan Miguel Guerrero Montávez
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla

Laboratory: 210

Juan Miguel Guerrero Montávez

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  1. Group members
  2. Research areas
  3. Publications

Group: Molecular neuroimmunoendocrinology

Group members Molecular neuroimmunoendocrinology
  • Álvarez López, Ana Isabel.Investigadora en Formación
  • Álvarez Ríos, Ana.Degree in Pharmacy. Resident - Clinical Analysis (HUVR).
  • Bejarano Hernando, Ignacio.Doctor en Biología
  • Blázquez Nieto, Yaiza.Investigadora Programa Yo Investigo
  • Carrillo Vico, Antonio.PhD in Biology. Assistant Professor Doctor (University of Seville).
  • Cruz Chamorro, Iván.Doctor en biología. Investigador posdoctoral
  • Guerrero Montávez, Juan Miguel.PhD in Biochemistry. Professor/Head of Service (US/HUVR).
  • Lardone, Patricia Judith.PhD in Biology. Assistant Professor Doctor (University of Seville).
  • Leal Noval, Manuel.Dr. en Medicina y Cirugía
  • López González, Antonio.Degree in Medicine.
  • Macher Manzano, Hada.Degree in Medicine & Surgery. Faculty Staff - Clinical Biochemistry (HUVR).
  • Molinero Hueso, Patrocinio.MD/PhD. Professor (University of Seville).
  • Parralejo Ayala, Iván.Investigador Predoctoral FPU. Ldo. en Bioquímica
  • Ponce España, Eduardo.Investigador Predoctoral - PIF
  • Rubio Calvo, Amalia.PhD in Biology. Associate Professor (University of Seville).
  • Santos Sánchez, Guillermo.Graduado en Dietética y Nutrición Humana. Investigador en Formación FPU.

Research areas

The main research lines of the group are related to melatonin and can be summarised as follows:

  • Synthesis of melatonin in the immune system.
    Our main line of research is in the field of melatonin, a hormone formerly related only to the pineal gland. Our group has demonstrated that this hormone is synthesised in significant quantities in human T lymphocytes, in which it behaves as an autocrine, paracrine and intracrine agent participating in the regulation of expression of the IL-2 gene and its receptor.
  • Mechanisms of action of melatonin in inmunocompetent cells.
    In the last few years we have described that the actions of melatonin in the immune system are mediated through their interaction with membrane receptors (MT1 and MT2) containing seven trans-membrane spanning domains, and with nuclear receptors of the ROR/RZR family, formerly considered as orphan receptors and for which melatonin could be their natural ligand. Both receptor types act synergistically to activate the production of IL-2 by human lymphocytes.
  • Melatonin as a natural compound.
    Independently of the production of melatonin by the pineal gland and numerous other peripheral tissues (immune system, alimentary canal, respiratory tract, etc.), melatonin is found in unicellular organisms and, in fact, in almost all living species in the plant and animal kingdoms. Our group has identified appreciable amounts of melatonin in olive oil and wine. The content is sufficient to elevate levels of melatonin in a human being with the single ingestion of two glasses of wine. The antioxidant effects of melatonin make these studies potentially important in the field of nutrition.
International Journals
Dominguez-Molina, B; Tarancon-Diez, L; Milanes-Guisado, Y; Genebat, M; Resino, S; Rodriguez, C; Gonzalez-Garcia, J; Rallon, N; Pernas, M; Casado, C; Lopez-Galindez, C; Leon, A; Benito, JM; Garcia, F; Del Romero, J; Viciana, P; Lopez-Cortes, LF; Leal, M; Ruiz-Mateos, E
Persistent HIV-controllers are more prone to spontaneously clear HCV: a retrospective cohort study
Alvarez-Sanchez, N; Chamorro, IC; Alvarez-Lopez, AI; Lopez-Gonzalez, A; Remigio, JRL; Lardone, PJ; Guerrero, JM; Martinez-Lopez, A; Carrillo-Vico, A
Seasonal Variations in Macrophages/Microglia Underlie Changes in the Mouse Model of Multiple Sclerosis Severity
Hernandez-Walias, F; Ruiz-de-Leon, MJ; Rosado-Sanchez, I; Vazquez, E; Leal, M; Moreno, S; Vidal, F; Blanco, J; Pacheco, YM; Vallejo, A
New signatures of poor CD4 cell recovery after suppressive antiretroviral therapy in HIV-1-infected individuals: involvement of miR-192, IL-6, sCD14 and miR-144
Vitalle, J; Terren, I; Gamboa-Urquijo, L; Orrantia, A; Tarancon-Diez, L; Genebat, M; Leal, M; Ruiz-Mateos, E; Borrego, F; Zenarruzabeitia, O
Polyfunctional HIV-1 specific response by CD8+T lymphocytes expressing high levels of CD300a
Vallejo, A; Molina-Pinelo, S; de Felipe, B; Abad-Fernandez, M; Gonzalez-Escribano, MF; Leal, M; Soriano-Sarabia, N
Brief Report: Toll-like Receptor 9-1635A/G Polymorphism Is Associated With HIV-1 Rebound After Four Weeks of Interruption of Antiretroviral Therapy
De Pablo-Bernal, RS; Jimenez-Leon, MR; Tarancon-Diez, L; Gutierrez-Valencia, A; Serna-Gallego, A; Trujillo-Rodriguez, M; Alvarez-Rios, AI; Milanes-Guisado, Y; Espinosa, N; Roca-Oporto, C; Viciana, P; Lopez-Cortes, LF; Ruiz-Mateos, E
Modulation of Monocyte Activation and Function during Direct Antiviral Agent Treatment in Patients Coinfected with HIV and Hepatitis C Virus
Lepe-Balsalobre, E; Santotoribio, JD; Nunez-Vazquez, R; Garcia-Morillo, S; Jimenez-Arriscado, P; Hernandez-Arevalo, P; Delarosa-Rodriguez, R; Guerrero, JM; Macher, HC
Genotype/phenotype relationship in Gaucher disease patients. Novel mutation in glucocerebrosidase gene
Rosado-Sanchez, I; De Pablo-Bernal, R; Rull, A; Gonzalez, J; Moreno, S; Vinuesa, D; Estrada, V; Munoz-Fernandez, MA; Vidal, F; Leal, M; Pacheco, YM
Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects
Montserrat-de la Paz, S; Rodriguez-Martin, NM; Villanueva, A; Pedroche, J; Cruz-Chamorro, I; Millan, F; Millan-Linares, MC
Evaluation of Anti-Inflammatory and Atheroprotective Properties of Wheat Gluten Protein Hydrolysates in Primary Human Monocytes
Hernandez-Walias, FJ; Vazquez, E; Pacheco, Y; Rodriguez-Fernandez, JM; Perez-Elias, MJ; Dronda, F; Casado, JL; Moreno, A; Hermida, JM; Quereda, C; Hernando, A; Tejerina-Picado, F; Asensi, V; Galindo, MJ; Leal, M; Moreno, S; Vallejo, A
Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21
Malo, AI; Rull, A; Girona, J; Domingo, P; Fuertes-Martin, R; Amigo, N; Rodriguez-Borjabad, C; Martinez-Micaelo, N; Leal, M; Peraire, J; Correig, X; Vidal, F; Masana, L
Glycoprotein Profile Assessed by H-1-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study
Cruz-Chamorro, I; Alvarez-Sanchez, N; Santos-Sanchez, G; Pedroche, J; Fernandez-Pachon, MS; Millan, F; Millan-Linares, MC; Lardone, PJ; Bejarano, I; Guerrero, JM; Carrillo-Vico, A
Immunomodulatory and Antioxidant Properties of Wheat Gluten Protein Hydrolysates in Human Peripheral Blood Mononuclear Cells
Tarancon-Diez L, Rodríguez-Gallego E, Rull A, Peraire J, Viladés C, Portilla I, Jimenez-Leon MR, Alba V, Herrero P, Leal M, Ruiz-Mateos E, Vidal F, ECRIS integrated in the Spanish AIDS Research Network
Immunometabolism is a key factor for the persistent spontaneous elite control of HIV-1 infection.
Cruz-Chamorro I, Álvarez-Sánchez N, Escalante-Andicoechea C, Carrillo-Vico A, Rubio A, Guerrero JM, Molinero P, Lardone PJ
Temporal expression patterns of the melatoninergic system in the human thymus of children.
Mol Metab.
Rosado-Sánchez I, Rodríguez-Gallego E, Peraire J, Viladés C, Herrero P, Fanjul F, Gutiérrez F, Bernal E, Pelazas R, Leal M, Veloso S, López-Dupla M, Blanco J, Vidal F, Pacheco YM, Rull A
Glutaminolysis and lipoproteins are key factors in late immune recovery in successfully treated HIV-infected patients.
Clin Sci (Lond)
Bristow CL, Ferrando-Martinez S, Ruiz-Mateos E, Leal M, Winston R
T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls.
Front Cell Dev Biol.
Rodríguez-Gallego E, Tarancón-Diez L, García F, Del Romero J, Benito JM, Alba V, Herrero P, Rull A, Dominguez-Molina B, Martinez-Madrid O, Martin-Pena L, Pulido F, León A, Rodríguez C, Rallón N, Peraire J, Viladés C, Leal M, Vidal F, Ruiz-Mateos E, HIV-1 Elite Controllers Study Group (ECRIS), Spanish AIDS Research Network
Proteomic Profile Associated With Loss of Spontaneous Human Immunodeficiency Virus Type 1 Elite Control.
J Infect Dis.
Álvarez-Sánchez N, Álvarez-Ríos AI, Guerrero JM, García-García FJ, Rodríguez-Mañas L, Cruz-Chamorro I, Lardone PJ, Carrillo-Vico A
Homocysteine and C-reactive protein levels are associated with frailty in older Spaniards: The Toledo Study for Healthy Aging.
J Gerontol A Biol Sci Med Sci.
Herrero-Fernández I, Rosado-Sánchez I, Álvarez-Ríos AI, Galvá MI, De Luna-Romero M, Sanbonmatsu-Gámez S, Pérez-Ruiz M, Navarro-Marí JM, Carrillo-Vico A, Sánchez B, Ramos R, Cañizares J, Leal M, Pacheco YM
Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people.
Immun Ageing.
Genebat M, Tarancón-Díez L, Pulido I, Álvarez-Ríos AI, Muñoz-Fernández MÁ, Ruiz-Mateos E, Leal M
Hepatitis C virus and cumulative infections are associated with atherogenic cardiovascular events in HIV-infected subjects.
Antiviral Res.
Álvarez-Sánchez N, Cruz-Chamorro I, Díaz-Sánchez M, Lardone PJ, Guerrero JM, Carrillo-Vico A
Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients.
Sci Rep.
Leon-Justel A, Alvarez-Rios AI, Noval-Padillo JA, Gomez-Bravo MA, Porras M, Gomez-Sosa L, Lopez-Romero JL, Guerrero JM .
Point-of-care haemostasis monitoring during liver transplantation is cost effective.
Clin Chem Lab Med
Guerrero-Beltrán C, Prieto A, Leal M, Jiménez JL, Muñoz-Fernández MÁ
Combination of G2-S16 dendrimer/dapivirine antiretroviral as a new HIV-1 microbicide.
Future Med Chem.
Cruz-Chamorro I, Álvarez-Sánchez N, Millán-Linares MDC, Yust MDM, Pedroche J, Millán F, Lardone PJ, Carrera-Sánchez C, Guerrero JM, Carrillo-Vico A
Lupine protein hydrolysates decrease the inflammatory response and improve the oxidative status in human peripheral lymphocytes.
Food Res Int.
Ruiz-Mateos E, Ruiz-León MJ, Tarancón-Díez L, Gutiérrez C, Dronda F, Domínguez-Molina B, Pérez-Elías MJ, Moreno A, Leal M, Moreno S, Vallejo A
High CD8 T cell percentage and HCV replication control are common features in HIV-1 controllers and HTLV-2-co-infected patients with a history of injection drug use.
Virus Res.
Macher HC, García-Fernández N, Adsuar-Gómez A, Porras-López M, González-Calle A, Noval-Padillo J, Guerrero JM, Molinero P, Borrego-Domínguez JM, Herruzo-Avilés Á, Rubio A
Donor-specific circulating cell free DNA as a noninvasive biomarker of graft injury in heart transplantation.
Clin Chim Acta
Ruiz-de-León MJ, Jiménez-Sousa MA, Moreno S, García M, Gutiérrez-Rivas M, León A, Montero-Alonso M, González-García J, Resino S, Rallón N, Benito JM, Vallejo A, ECRIS Network integrated in the Spanish AIDS Research Network
Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count.
J Microbiol Immunol Infect
Espino J, Macedo M, Lozano G, Ortiz Á, Rodríguez C, Rodríguez AB, Bejarano I.
Impact of Melatonin Supplementation in Women With Unexplained Infertility Undergoing Fertility Treatment
Antioxidants (Basel)
Álvarez-Sánchez N, Álvarez-Ríos AI, Guerrero JM, García-García FJ, Rodríguez-Mañas L, Cruz-Chamorro I, Lardone PJ, Carrillo-Vico A.
Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women: The Toledo Study for Healthy Aging.
Exp Gerontol.
Delgado Pecellín I, Pérez Ruiz E, Álvarez Ríos AI, Delgado Pecellín C, Yahyaoui Macías R, Carrasco Hernández L, Marcos Luque I, Caro Aguilera P, Moreno Valera MJ, Quintana Gallego ME.
Results of the Andalusian Cystic Fibrosis Neonatal Screening Program, 5 Years After Implementation
Arch Bronconeumol.
Di Somma A, Cancela Caro P, Blanco MO, Somma T, López-González A, Campero A, Emmerich J, Márquez-Rivas J.
Modified "Extended" Suboccipital Subtonsillar Clipping of a Ruptured Proximal Pica Aneurysm: Technical Note with Relevant Anatomical Demonstration.
World Neurosurg
Egea-Guerrero JJ, Rodríguez-Rodríguez A, Quintana-Díaz M, Freire-Aragón MD, Raya-Collados D, Hernández-García C, Ortiz-Manzano Á, Vilches-Arenas Á, Díez-Naz A, Guerrero JM, Murillo-Cabezas F.
Validation of S100B use in a cohort of Spanish patients with mild traumatic brain injury: a multicentre study
Brain Inj.
Escudero-López B, Ortega Á, Cerrillo I, Rodríguez-Griñolo MR, Muñoz-Hernández R, Mácher HC, Martín F, Hornero-Méndez D, Mena P, del Río D, Fernández-Pachón MS.
Consumption of orange fermented beverage improves antioxidant status and reduces peroxidation lipid and inflammatory markers in healthy humans.
J Sci Food Agric.
Ferro M, Mácher HC, Fornés G, Martín-Sánchez J, Jiménez-Arriscado P, Molinero P, Pérez-Simón JA, Guerrero JM, Rubio A.
Noninvasive prenatal diagnosis by cell-free DNA screening for fetomaternal HPA-1a platelet incompatibility.
Ley-Martos M, Guerrero JM, Lucas-Javato M, Remón-García C, García-Lozano JR, Colón C, Crujeiras P, Rodrigues D, Paúl-Sánchez P, Mácher HC.
Family study of a novel mutation of mucopolysaccharidosis type VI with a severe phenotype and good response to enzymatic replacement therapy: Case report.
Montserrat-de la Paz S, López S, Bermúdez B, Guerrero JM, Abia R, Muriana FJ.
Effects of immediate-release niacin and dietary fatty acids on acute insulin and lipid status in individuals with metabolic syndrome.
J Sci Food Agric.
Ruiz-Mateos E, Tarancón-Díez L, Álvarez-Ríos AI, Domínguez-Molina B, Genebat M, Pulido I, Abad MA, Muñoz-Fernández MA, Leal M.
Association of heterozygous CCR5Δ32 deletion with survival in HIV-infection: A cohort study.
Antiviral Res.
Tarancón-Díez L, De Pablo-Bernal RS, Jiménez JL, Álvarez-Ríos AI, Genebat M, Rosado-Sánchez I, Muñoz-Fernández MÁ, Ruiz-Mateos E, Leal M.
Role of toll-like receptor 4 Asp299Gly polymorphism in the development of cardiovascular diseases in HIV-infected patients
Books and articles in books
Trujillo-Rodriguez, M; Viciana, P; Rivas-Jeremias, I; Alvarez-Rios, AI; Ruiz-Garcia, A; Espinosa-Ibanez, O; Arias-Santiago, S; Martinez-Atienza, J; Mata, R; Fernandez-Lopez, O; Ruiz-Mateos, E; Gutierrez-Valencia, A; Lopez-Cortes, LF
Mesenchymal stromal cells in Human Immunodeficiency Virus-infected patients with discordant immune response: Early results of a phase I/II clinical trial
Alvarez-Sanchez, N; Alvarez-Rios, AI; Guerrero, JM; Garcia-Garcia, FJ; Rodriguez-Manas, L; Cruz-Chamorro, I; Lardone, PJ; Carrillo-Vico, A
Homocysteine and C-Reactive Protein Levels Are Associated With Frailty in Older Spaniards: The Toledo Study for Healthy Aging