Dr. Miguel Ángel Burguillos García is an Emerging Researcher at the Institute of Biomedicine of Sevilla (IBiS)
The Emerging Researchers at IBiS are early-career scientists whose positions are usually funded through competitive national programmes (e.g. Ramón y Cajal) or international ones (e.g. ERC). These researchers are scientifically independent and have their own budgets to manage their laboratories, which come from the research projects they lead and fund. Therefore, they are able to publish independently.
IBiS provides laboratory space, access to all research facilities, and a mentor who is a Principal Investigator (PI) at IBiS. Emerging Researchers are part of the IBiS Scientific Council and are expected to independently supervise PhD and Master’s students. Emerging Researchers are expected to develop an excellent scientific track record that will enable them to successfully compete for an academic or equivalent position and place them in a position to become PIs at IBiS.
Dr José Luis Venero Recio is the mentor of Dr Burguillos García.
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In our group, we investigate the regulation of the inflammatory phenotype of microglia, the immune cells of the brain, under physiological conditions as well as pathological conditions such as Parkinson's disease and Alzheimer's disease.
Our group focuses on microglia cell signalling that is under the control of the "executioner" caspases-3 and -7 in a non-apoptotic context. We investigate the signalling pathways affected by caspase activation in neuroinflammatory conditions, and on the pathways regulated by the basal activity of those caspases under physiological conditions.
A separate line of research conducted in our group is the study of the epigenetic regulation of microglial activation and how it affects Parkinson’s disease progression.
Research Lines:
• Role of microglial caspase-3 and caspase-7 in Parkinson´s and Alzheimer´s diseases1-3.
• Role of TET2 controlling microglial activation in PD4.
Selected publications:
1. Caspase signalling controls microglia activation and neurotoxicity.
Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, Cano J, Brundin P, Englund E, Venero JL, Joseph B.
Nature. 2011 Apr 21;472(7343):319-24. doi: 10.1038/nature09788. Epub 2011 Mar 9.
PMID: 21389984
2. Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.
Shen X*, Burguillos MA*, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, Augsten M, Saidi D, Rodhe J, Kavanagh E, Rongvaux A, Rraklli V, Nyman U, Holmberg J, Östman A, Flavell RA, Barragan A, Venero JL, Blomgren K, Joseph B. (*Shared first authorship)
Nat Immunol. 2016 Nov;17(11):1282-1290. doi: 10.1038/ni.3545. Epub 2016 Sep 12.
PMID: 27618552
3. Caspases orchestrate microglia instrumental functions.
Shen X, Venero JL, Joseph B, Burguillos MA.
Prog Neurobiol. 2018 Dec;171:50-71. doi: 10.1016/j.pneurobio.2018.09.007. Epub 2018 Oct 2.
PMID: 30290215 Review.
4. TET2 Regulates the Neuroinflammatory Response in Microglia.
Carrillo-Jimenez A, Deniz Ö, Niklison-Chirou MV, Ruiz R, Bezerra-Salomão K, Stratoulias V, Amouroux R, Yip PK, Vilalta A, Cheray M, Scott-Egerton AM, Rivas E, Tayara K, García-Domínguez I, Garcia-Revilla J, Fernandez-Martin JC, Espinosa-Oliva AM, Shen X, St George-Hyslop P, Brown GC, Hajkova P, Joseph B, Venero JL, Branco MR, Burguillos MA.
Cell Rep. 2019 Oct 15;29(3):697-713.e8. doi: 10.1016/j.celrep.2019.09.013.
PMID: 316186372.
