Oncohematology and Genetics

Cell therapy and new therapeutic targets in onco-hematology

José Antonio Pérez Simón
José Antonio Pérez Simón
IBiS
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla

Laboratory: 202
Iván  Valle Rosado
Iván Valle Rosado
IBiS
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla

José Antonio Pérez Simón

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  1. Group members
  2. Research areas
  3. Publications

Group: Cell therapy and new therapeutic targets in onco-hematology

Directory
Group members Cell therapy and new therapeutic targets in onco-hematology
  • Arribas Arribas, Blanca.Técnico Control de Calidad
  • Bejarano García, José Antonio.Ldo. en Biología
  • Bermejo González, María.Técnico Control de Calidad
  • Caballero Velázquez, Teresa.Doctor en Medicina. Post-MIR, Río Hortega.
  • Calderón Cabrera , Cristina.Doctora en Medicina. Post-MIR. Río-Hortega.
  • Caracuel García, Rocío .Técnico de Anatomía Patológica
  • Contreras Mostazo, Miriam Guadalupe.
  • de la Rosa Garrido, Mª Dolores.Técnico de Apoyo
  • de la Torre Madrid, Elena .Lda. en Bioquímica. Gestión de Proyectos. Dra. en Ciencias Biológicas
  • Escamilla Gómez, Virginia.FEA HUVR
  • Falantes González, José F.Ldo. en Medicina. FEA-Hematología (HUVR).
  • García Calderón, Clara Beatriz.Dra. en Biología.
  • García Decena, Adriana.
  • García Guerrero, Estefania.Degree in Biotechnology. PhD student.
  • González Campos, José.Doctor en Medicina
  • Hernández Díaz, Paola.Técnico Superior de Laboratorio (FP2). Técnico.
  • Lara Chica, Mª Isabel.Investigadora Postdoctoral. Doctora en Biomedicina
  • Magaz Cuevas, Jorge.Diplomado en Ciencias Empresariales. Técnico.
  • Martínez Cibrian, Nuria.FEA HUVR
  • Medrano Domínguez, Mayte.Lda. en Biotecnología. Investigadora predoctoral.
  • Mingot Castellano, Eva.FEA HUVR. DOCTORADO EN ACTUALIZACION EN FARMACOLOGIA
  • Molinos Quintana, Agueda.Lda. en medicina. DOCTORADO EN ACTUALIZACION EN FARMACOLOGIA
  • Montero Cuadrado, Isabel.Lda. en Medicina. FEA-Hematología (HUVR). Doctorado en Biología Molecular y Biomedicina
  • Montiel Aguilera, Miguel Angel.Técnico Garantía de Calidad
  • Morales Camacho, Rosario.Doctor en Medicina. FEA-Hematología (HUVR).
  • Moreno Gordillo , Paula.Investigadora en Formación
  • Nufer, Melanie Elisabeth.Investigadora en Formación
  • Núñez Vázquez, Ramiro.Dr. en Medicina. FEA-Hematología (HUVR).
  • Peña Gómez, María José .Investigadora en Formación
  • Pérez Hurtado, José Mª.Ldo. en Medicina. FEA-Hematología (HUVR).
  • Pérez Ortega, Laura.Lda. en Medicina y Cirugía
  • Pérez Simón, José Antonio.MD/PhD. Head of Service (HUVR).
  • Rodríguez Arbolí, Eduardo.FEA HUVR
  • Rodríguez Gil , Alfonso.Investigador Postdoctoral. Doctor en Biología
  • Rodríguez Martorell, Fco. Javier.Doctor en Medicina
  • Rojas Martínez, Javier Alberto.FEA HUVR
  • Sanoja Flores, Luzalba.Investigadora Postdoctoral. Doctora en Biomedicina
  • Sierro Martínez, Belén.Investigadora en Formación
  • Soria Saldise , Elena.Investigadora Postdoctoral. Dra. en Biología Molecular y Celular
  • Valle Rosado, Iván .Contratado Ramón y Cajal Dpto. Genética, Universidad de Sevilla Dr. en Biología

Research areas

The Department of Hematology of the University Hospital Virgen del Rocío/Instituto de Biomedicina de Sevilla (IBiS) is one of the largest in Spain, providing a range of services for the different disciplines within this field, and serving as a national reference centre in several of these. Our laboratory in the IBIS complex is focused on traslational research in Hematology with a view to taking advantage of the enormous potential contained within the different disciplines.

Our main areas of interest are the following:

1.    Cell therapy and hematopoietic stem cell transplantation:

  • Immunomodulation and new drugs: we have described the immunomodulatory effect of several new drugs and their potential use within the allogeneic transplant setting. Several drugs are currently being evaluated using this approach.
  • Cell therapy and transplantation: we have developed a new method to induce allodepletion, which allows the immune response against pathogens or tumor cells to be maintained; this technique will be used in a clinical context, or more specifically, in the haploidentical transplant setting.
  • Mesenchymal stem cells: we are evaluating the immunomodulatory properties and differentiation capabilities of these cells. The first clinical trial for patients diagnosed with graft-versus-host disease (GVHD) has been completed based on these data and a new trial is currently underway.

2.    New therapeutic targets

  • Tumor stem cells: we are carrying out molecular and genetic studies in patients with MDS and AML to identify specific pathways which are overactivated in tumor versus normal hematopoietic stem cells.

3. All these projects are performed ex vivo and in animal models (both mouse and large animal models, in collaboration with other groups). Our aim is to translate the approaches used to a clinical setting: "From bedside to bench and back".

International Journals
Ribera, JM; Morgades, M; Montesinos, P; Tormo, M; Martinez-Carballeira, D; Gonzalez-Campos, J; Gil, C; Barba, P; Garcia-Boyero, R; Coll, R; Pedreno, M; Ribera, J; Mercadal, S; Vives, S; Novo, A; Genesca, E; Hernandez-Rivas, JM; Bergua, J; Amigo, ML; Vall-Llovera, F; Martinez-Sanchez, P; Calbacho, M; Garcia-Cadenas, I; Garcia-Guinon, A; Sanchez-Sanchez, MJ; Cervera, M; Feliu, E; Orfao, A
A pediatric regimen for adolescents and young adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: Results of the ALLRE08 PETHEMA trial
CANCER MEDICINE
Prats-Martin, C; Burillo-Sanz, S; Morales-Camacho, RM; Perez-Lopez, O; Suito, M; Vargas, MT; Caballero-Velazquez, T; Carrillo-Cruz, E; Gonzalez, J; Bernal, R; Perez-Simon, JA
ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia-related changes and normal karyotype
CANCER MEDICINE
Fernandez-Munoz, B; Rosell-Valle, C; Ferrari, D; Alba-Annador, J; Montiel, MA; Campos-Cuerva, R; Lopez-Navas, L; Munoz-Escalona, M; Martin-Lopez, M; Profico, DC; Blanco, MF; Giorgetti, A; Gonzalez-Munoz, E; Marquez-Rivas, J; Sanchez-Pernaute, R
Retrieval of germinal zone neural stem cells from the cerebrospinal fluid of premature infants with intraventricular hemorrhage
STEM CELLS TRANSLATIONAL MEDICINE
Rodriguez-Barbosa, JI; Azuma, M; Zelinskyy, G; Perez-Simon, JA; del Rio, ML
Critical role of PD-L1 expression on non-tumor cells rather than on tumor cells for effective anti-PD-L1 immunotherapy in a transplantable mouse hematopoietic tumor model
CANCER IMMUNOLOGY IMMUNOTHERAPY
Alvarez-Laderas, I; Ramos, TL; Medrano, M; Caracuel-Garcia, R; Barbado, MV; Sanchez-Hidalgo, M; Zamora, R; Alarcon-de-la-Lastra, C; Hidalgo, FJ; Piruat, JI; Caballero-Velazquez, T; Perez-Simon, JA
Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Ribera, JM; Garcia, O; Chapchap, EC; Gil, C; Gonzalez-Campos, J; Barba, P; Amigo, ML; Moreno, MJ; Lavilla, E; Alonso, N; Bergua, JM; Tormo, M; Ribera, J; Sierra, M; Martinez-Carballeira, D; Mercadal, S; Hernandez-Rivas, JM; Vall-Llovera, F; Genesca, E; Cladera, A; Novo, A; Abella, E; Garcia-Cadenas, I; Monteserin, C; Bermudez, A; Piernas, S; Montesinos, P; Lopez, JL; Garcia-Guinon, A; Serrano, A; Martinez, MP; Olivares, M; Lopez, A; Serrano, J
Treatment of Frail Older Adults and Elderly Patients With Philadelphia Chromosome-negative Acute Lymphoblastic Leukemia: Results of a Prospective Trial With Minimal Chemotherapy
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
Romero-Azogil, L; Benito, JM; Pinilla, IM; Hakkou, K; Martinez, MB; Canton, I; Lopez-Cornejo, P; Garcia-Calderon, CB; Rosado, IV; Garcia-Martin, MG; Benito, E
Structure-property relationships of D-mannitol-based cationic poly(amide triazoles) and their self-assembling complexes with DNA
EUROPEAN POLYMER JOURNAL
Rodriguez-Medina, C; Martinez-Cuadron, D; Cano, I; Gil, C; Tormo, M; Martinez-Sanchez, MD; del Castillo, TB; Serrano-Lopez, J; Benavente, C; Herrera-Puente, P; Garcia-Boyero, R; Lavilla-Rubira, E; Amigo, ML; Sayas-Llorisn, MJ; Bergua-Burgues, JM; Perez-Simon, JA; Rodriguez, G; Espadana, A; Vidriales-Vicente, B; Fernandez, R; Lopez-Lorenzo, JL; Lopez, M; Garcia-Fortes, M; Gomez, JL; Colorado-Araujo, M; Sossa-Melo, CL; Aguilar, E; Fernandez, PM
Performance of prognostic scoring systems in elderly patients with acute myeloid leukaemia on intensive chemotherapy: A PETHEMA registry study
LEUKEMIA RESEARCH
Ostos, FJ; Lebron, JA; Lopez-Cornejo, P; Lopez-Lopez, M; Garcia-Calderon, M; Garcia-Calderon, CB; Rosado, IV; Kalchenko, VI; Rodik, RV; Moya, ML
Self-aggregation in aqueous solution of amphiphilic cationic calix[4] arenes. Potential use as vectors and nanocarriers
JOURNAL OF MOLECULAR LIQUIDS
Martinez-Cuadron, D; Serrano, J; Gil, C; Tormo, M; Martinez-Sanchez, P; Perez-Simon, JA; Garcia-Boyero, R; Rodriguez-Medina, C; Lopez-Pavia, M; Benavente, C; Bergua, J; Lavilla-Rubira, E; Amigo, ML; Herrera, P; Alonso-Dominguez, JM; Bernal, T; Colorado, M; Sayas, MJ; Algarra, L; Vidriales, MB; Rodriguez-Macias, G; Vives, S; Perez-Encinas, MM; Lopez, A; Noriega, V; Garcia-Fortes, M; Ramos, F; Rodriguez-Gutierrez, JI; Costilla-Barriga, L; Labrador, J; Boluda, B; Rodriguez-Veiga, R; Martinez-Lopez, J; Sanz, MA; Montesinos, P
Evolving treatment patterns and outcomes in older patients (>= 60 years) with AML: changing everything to change nothing?
LEUKEMIA
Garcia-Guerrero, E; Gotz, R; Doose, S; Sauer, M; Rodriguez-Gil, A; Nerreter, T; Kortum, KM; Perez-Simon, JA; Einsele, H; Hudecek, M; Danhof, S
Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab
LEUKEMIA
Caballero-Velazquez, T; Calderon-Cabrera, C; Lopez-Corral, L; Puig, N; Marquez-Malaver, F; Perez-Lopez, E; Garcia-Calderon, C; Rosso-Fernandez, CM; Barrigon, DC; Martin, J; Mateos, MV; San Miguel, J; Perez-Simon, JA
Efficacy of bortezomib to intensify the conditioning regimen and the graft-versus-host disease prophylaxis for high-risk myeloma patients undergoing transplantation
BONE MARROW TRANSPLANTATION
Gomez, VE; Garcia-Gutierrez, V; Corral, LL; Cadenas, IG; Martinez, AP; Malaver, FMJ; Caballero-Velazquez, T; Sierra, PGA; Alegria, MCV; Salinas, IPM; Cabrera, CC; Vicent, MG; Torres, NR; Porras, RP; Coll, CF; Orti, G; Ferreiras, DV; Llanza, RD; Moles, P; Velazquez-Kennedy, K; Mende, MJ; Barrigon, DC; Perez, E; Bofarull, RM; Gerosa, SS; Sierra, J; Poch, M; Ripa, MTZ; Perez, MDA; Angulo, BM; Ortega, IS; Caballer, JS; Gomez, JM; Tocino, IE; Perez-Simon, JA
Ruxolitinib in refractory acute and chronic graft-versus-host disease: a multicenter survey study
BONE MARROW TRANSPLANTATION
Prata, PH; Eikema, DJ; Afansyev, B; Bosman, P; Smiers, F; Diez-Martin, JL; Arrais-Rodrigues, C; Koc, Y; Poire, X; Sirvent, A; Kroeger, N; Porta, F; Holter, W; Bloor, A; Jubert, C; Ganser, A; Tanase, A; Menard, AL; Pioltelli, P; Perez-Simon, JA; Ho, A; Aljurf, M; Russell, N; Labussiere-Wallet, H; Kerre, T; Rocha, V; Socie, G; Risitano, A; Dufour, C; de Latour, RP
Haploidentical transplantation and posttransplant cyclophosphamide for treating aplastic anemia patients: a report from the EBMT Severe Aplastic Anemia Working Party
BONE MARROW TRANSPLANTATION
Costa, LJ; Iacobelli, S; Pasquini, MC; Modi, R; Giaccone, L; Blade, J; Schonland, S; Evangelista, A; Perez-Simon, JA; Hari, P; Brown, EE; Giralt, SA; Patriarca, F; Stadtmauer, EA; Rosinol, L; Krishnan, AY; Gahrton, G; Bruno, B
Long-term survival of 1338 MM patients treated with tandem autologous vs. autologous-allogeneic transplantation
BONE MARROW TRANSPLANTATION
Sanchez-Lopez, V; Gao, L; Ferrer-Galvan, M; Arellano-Orden, E; Elias-Hernandez, T; Jara-Palomares, L; Asensio-Cruz, MI; Castro-Perez, MJ; Rodriguez-Martorell, FJ; Lobo-Beristain, JL; Ballaz-Quincoces, A; Lopez-Campos, JL; Vila-Liante, V; Otero-Candelera, R
Differential biomarker profiles between unprovoked venous thromboembolism and cancer
ANNALS OF MEDICINE
Fuster, JL; Molinos-Quintana, A; Fuentes, C; Fernandez, JM; Velasco, P; Pascual, T; Rives, S; Dapena, JL; Sisinni, L; Lopez-Godino, O; Palomo, P; Villa-Alcazar, M; Bautista, F; Gonzalez-Vicent, M; Lopez-Duarte, M; Garcia-Morin, M; Ramos-Elbal, E; Ramirez, M
Blinatumomab and inotuzumab for B cell precursor acute lymphoblastic leukaemia in children: a retrospective study from the Leukemia Working Group of the Spanish Society of Pediatric Hematology and Oncology (SEHOP)
BRITISH JOURNAL OF HAEMATOLOGY
Ocio, EM; Motllo, C; Rodriguez-Otero, P; Martinez-Lopez, J; Cejalvo, MJ; Martin-Sanchez, J; Blad, J; Garcia-Malo, MD; Dourdil, MV; Garcia-Mateo, A; de Arriba, F; Garcia-Sanz, R; de la Rubia, J; Oriol, A; Lahuerta, JJ; San-Miguel, JF; Mateos, MV
Filanesib in combination with pomalidomide and dexamethasone in refractory MM patients: safety and efficacy, and association with alpha 1-acid glycoprotein (AAG) levels. Phase Ib/II Pomdefil clinical trial conducted by the Spanish MM group
BRITISH JOURNAL OF HAEMATOLOGY
Sobas, M; Rodriguez-Veiga, R; Vellenga, E; Paluszewska, M; De la Serna, J; Garcia-Alvarez, F; Gil, C; Brunet, S; Bergua, J; Gonzalez-Campos, J; Ribera, JM; Tormo, M; Gonzalez, M; Fernandez, I; Benavente, C; Gonzalez-Sanmiguel, JD; Esteve, J; Perez-Encinas, M; Salamero, O; Manso, F; Lowenberg, B; Sanz, MA; Montesinos, P
Characteristics and outcome of adult patients with acute promyelocytic leukemia and increased body mass index treated with the PETHEMA Protocols
EUROPEAN JOURNAL OF HAEMATOLOGY
Hayden, PJ; Iacobelli, S; Perez-Simon, JA; van Biezen, A; Minnema, M; Niittyvuopio, R; Schonland, S; Meijer, E; Blaise, D; Milpied, N; Marquez-Malaver, FJ; Veelken, JH; Maertens, J; Michallet, M; Cammenga, J; N'Guyen, S; Niederwieser, D; Hunault-Berger, M; Bourhis, JH; Passweg, J; Bermudez, A; Chalandon, Y; Yakoub-Agha, I; Garderet, L; Kroger, N
Conditioning-based outcomes after allogeneic transplantation for myeloma following a prior autologous transplant (1991-2012) on behalf of EBMT CMWP
EUROPEAN JOURNAL OF HAEMATOLOGY
Gudiol, C; Arnan, M; Aguilar-Guisado, M; Royo-Cebrecos, C; Sanchez-Ortega, I; Montero, I; Martin-Gandul, C; Laporte-Amargis, J; Albasanz-Puig, A; Nicolae, S; Perayre, M; Berbel, D; Tebe, C; Riera, J; Sureda, A; Cisneros, JM; Carratala, J
A Randomized, Double-Blind, Placebo-Controlled Trial (TAURCAT Study) of Citrate Lock Solution for Prevention of Endoluminal Central Venous Catheter Infection in Neutropenic Hematological Patients
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Mancha, F; Escudero-Martinez, I; Zapata-Arriaza, E; Vega-Salvatierra, A; Cabezas, JA; Lebrato, L; Pardo, B; De-La-Torre, J; Zapata, M; Escamilla, V; Calderon-Cabrera, C; Martin-Sanchez, J; Valverde, R; Aguera-Morales, E; Herrera, I; Delgado, F; Gamero, MA; Perez-Sanchez, S; Moya, M; Espinosa, R; Ortega-Quintanilla, J; Gutierrez-Jarrin, I; Gonzalez-Garcia, A; Montaner, J; Moniche, F
Circulating microRNA after autologous bone marrow mononuclear cell (BM-MNC) injection in patients with ischemic stroke
JOURNAL OF INVESTIGATIVE MEDICINE
Paiva, B; Puig, N; Cedena, MT; Rosinol, L; Cordon, L; Vidriales, MB; Burgos, L; Flores-Montero, J; Sanoja-Flores, L; Lopez-Anglada, L; Maldonado, R; de la Cruz, J; Gutierrez, NC; Calasanz, MJ; Martin-Ramos, ML; Garcia-Sanz, R; Martinez-Lopez, J; Oriol, A; Blanchard, MJ; Rios, R; Martin, J; Martinez-Martinez, R; Sureda, A; Hernandez, MT; de la Rubia, J; Krsnik, I; Moraleda, JM; Palomera, L; Bargay, J; Van Dongen, JJM; Orfao, A; Mateos, MV; Blade, J; San-Miguel, JF; Lahuerta, JJ
Measurable Residual Disease by Next-Generation Flow Cytometry in Multiple Myeloma
JOURNAL OF CLINICAL ONCOLOGY
Genesca, E; Morgades, M; Montesinos, P; Barba, P; Gil, C; Guardia, R; Moreno, MJ; Martinez-Carballeira, D; Garcia-Cadenas, I; Vives, S; Ribera, J; Gonzalez-Campos, J; Gonzalez-Gil, C; Zamora, L; Ramirez, JL; Diaz-Beya, M; Mercadal, S; Artola, MT; Cladera, A; Tormo, M; Bermudez, A; Vall-Llovera, F; Martinez, P; Amigo, ML; Monsalvo, S; Novo, A; Cervera, M; Garcia-Guinon, A; Junca, J; Ciudad, J; Orfao, A; Ribera, JM
Unique clinico-biological, genetic and prognostic features of adult early T-cell precursor acute lymphoblastic leukemia
HAEMATOLOGICA
Garcia-Guerrero, E; Sierro-Martinez, B; Perez-Simon, JA
Overcoming Chimeric Antigen Receptor (CAR) Modified T-Cell Therapy Limitations in Multiple Myeloma
FRONTIERS IN IMMUNOLOGY
Puig, N; Corchete-Sanchez, LA; Perez-Moran, JJ; Davila, J; Paino, T; de la Rubia, J; Oriol, A; Martin-Sanchez, J; de Arriba, F; Blad, J; Blanchard, MJ; Gonzalez-Calle, V; Garcia-Sanz, R; Paiva, B; Lahuerta, JJ; San-Miguel, JF; Mateos, MV; Ocio, EM
Pembrolizumab as Consolidation Strategy in Patients with Multiple Myeloma: Results of the GEM-Pembresid Clinical Trial
CANCERS
Rodriguez-Barbosa, JI; Schneider, P; Graca, L; Buhler, L; Perez-Simon, JA; del Rio, ML
The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lebron, JA; Ostos, FJ; Lopez-Lopez, M; Moya, ML; Sales, C; Garcia, E; Garcia-Calderon, CB; Garcia-Calderon, M; Pena-Gomez, MJ; Rosado, IV; Balestra, FR; Huertas, P; Lopez-Cornejo, P
Metallo-Liposomes of Ruthenium Used as Promising Vectors of Genetic Material
PHARMACEUTICS
Perez, C; Botta, C; Zabaleta, A; Puig, N; Cedena, MT; Goicoechea, I; Alameda, D; San Jose-Eneriz, E; Merino, J; Rodriguez-Otero, P; Maia, C; Alignani, D; Maiso, P; Manrique, I; Lara-Astiaso, D; Vilas-Zornoza, A; Sarvide, S; Riillo, C; Rossi, M; Rosinol, L; Oriol, A; Blanchard, MJ; Rios, R; Sureda, A; Martin, J; Martinez, R; Bargay, J; de la Rubia, J; Hernandez, MT; Martinez-Lopez, J; Orfao, A; Agirre, X; Prosper, F; Mateos, MV; Lahuerta, JJ; Blade, J; San-Miguel, JF; Paiva, B
Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma
BLOOD
Martinez-Cibrian N; Zeiser R; Perez-Simon JA
Graft-versus-host disease prophylaxis: Pathophysiology-based review on current approaches and future directions
Blood reviews
García-García A, Korn C, García-Fernández M, Domingues O, Villadiego J, Martín-Pérez D, Isern J, Bejarano-García JA, Zimmer J, Pérez-Simón JA, Toledo-Aral JJ, Michel T, Airaksinen MS, Méndez-Ferrer S
Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes.
Blood.
Lahuerta JJ, Jiménez-Ubieto A, Paiva B, Martínez-López J, González-Medina J, López-Anglada L, Cedena MT, Puig N, Oriol A, Blanchard MJ, Ríos R, Martin J, Martínez R, Sureda A, Hernández MT, de la Rubia J, Krsnik I, Cabañas V, Palomera L, Bargay J, Mateos MV, Rosiñol L, San Miguel JF, Blade J
Role of urine immunofixation in the complete response assessment of MM patients other than light-chain-only disease.
Blood.
Morales-Camacho RM, Prats-Martín C
Eosinophils with ring-shaped nuclei in a patient treated with adalimumab.
Blood.
Pérez-Ortega L, Morales-Camacho RM
Nuclear protrusion in dysplastic micromegakaryocytes.
Blood.
Carrillo-Cruz E, García-Lozano JR, Márquez-Malaver FJ, Sánchez-Guijo FM, Montero Cuadrado I, Ferra I Coll C, Valcárcel D, López-Godino O, Cuesta M, Parody R, López-Corral L, Alcoceba M, Caballero-Velázquez T, Rodríguez-Gil A, Bejarano-García JA, Ramos TL, Pérez-Simón JA
Vitamin D Modifies the Incidence of Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation Depending on the Vitamin D Receptor (VDR) Polymorphisms.
Clin Cancer Res.
Rodriguez-Barbosa JI, Schneider P, Weigert A, Lee KM, Kim TJ, Perez-Simon JA, Del Rio ML
HVEM, a cosignaling molecular switch, and its interactions with BTLA, CD160 and LIGHT.
Cell Mol Immunol.
Ribera JM, García O, Moreno MJ, Barba P, García-Cadenas I, Mercadal S, Montesinos P, Barrios M, González-Campos J, Martínez-Carballeira D, Gil C, Ribera J, Vives S, Novo A, Cervera M, Serrano J, Lavilla E, Abella E, Tormo M, Amigo ML, Artola MT, Genescà E, Bravo P, García-Belmonte D, García-Guiñón A, Hernández-Rivas JM, Feliu E, PETHEMA Group of the Spanish Society of Hematology
Incidence and outcome after first molecular versus overt recurrence in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia included in the ALL Ph08 trial from the Spanish PETHEMA Group.
Cancer.
Preciado S, Muntión S, Corchete LA, Ramos TL, de la Torre AG, Osugui L, Rico A, Espinosa-Lara N, Gastaca I, Díez-Campelo M, Del Cañizo C, Sánchez-Guijo F
Cells Increases Their Clonogenic Capacity and Bone Marrow Lodging Ability.
Stem Cells.
Cejalvo MJ, Legarda M, Abella E, Cabezudo E, Encinas C, García-Feria A, Gironella M, Iñigo B, Martín J, Ribas P, Ruíz MÁ, González Y, Vicuña I, Ramírez Á, Fernández P, de la Rubia J
Single-agent daratumumab in patients with relapsed and refractory multiple myeloma requiring dialysis: results of a Spanish retrospective, multicentre study.
Br J Haematol.
Ribera J, Granada I, Morgades M, Vives S, Genescà E, González C, Nomdedeu J, Escoda L, Montesinos P, Mercadal S, Coll R, González-Campos J, Abella E, Barba P, Bermúdez A, Gil C, Tormo M, Pedreño M, Martínez-Carballeira D, Hernández-Rivas JM, Orfao A, Martínez-López J, Esteve J, Bravo P, Garcia-Guiñon A, Debén G, Moraleda JM, Queizán JA, Ortín X, Moreno MJ, Feliu E, Solé F, Ribera JM, PETHEMA Group, Spanish Society of Haematology
The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients.
Br J Haematol.
Prata PH, Eikema DJ, Afansyev B, Bosman P, Smiers F, Diez-Martin JL, Arrais-Rodrigues C, Koc Y, Poiré X, Sirvent A, Kröger N, Porta F, Holter W, Bloor A, Jubert C, Ganser A, Tanase A, Ménard AL, Pioltelli P, Pérez-Simón JA, Ho A, Aljurf M, Russell N, Labussiere-Wallet H, Kerre T, Rocha V, Socié G, Risitano A, Dufour C, Peffault de Latour R, SAA WP of the EBMT
Haploidentical transplantation and posttransplant cyclophosphamide for treating aplastic anemia patients: a report from the EBMT Severe Aplastic Anemia Working Party.
Bone Marrow Transplant.
Lebrón JA, Ostos FJ, López-López M, Moyá ML, Kardell O, Sánchez A, Carrasco CJ, García-Calderón M, García-Calderón CB, Rosado IV, López-Cornejo P
Preparation and characterization of metallomicelles of Ru(II). Cytotoxic activity and use as vector.
Colloids Surf B Biointerfaces.
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Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae.
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Colom-Fernández B, Kreutzman A, Marcos-Jiménez A, García-Gutiérrez V, Cuesta-Mateos C, Portero-Sainz I, Pérez-García Y, Casado LF, Sánchez-Guijo F, Martínez-López J, Ayala RM, Boqué C, Xicoy B, Montero I, Soto C, Paz R, Silva G, Vega-Piris L, Steegmann JL, Muñoz-Calleja C
Immediate Effects of Dasatinib on the Migration and Redistribution of Naïve and Memory Lymphocytes Associated With Lymphocytosis in Chronic Myeloid Leukemia Patients.
Front Pharmacol.
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Response to Novel Drugs before and after Allogeneic Stem Cell Transplantation in Patients with Relapsed Multiple Myeloma.
Biol Blood Marrow Transplant.
Rodríguez-Arbolí E, Márquez-Malaver FJ, Rodríguez-Torres N, Caballero-Velázquez T, Escamilla-Gómez V, Calderón-Cabrera C, Falantes-González JF, Solé-Rodríguez M, García-Ramírez P, Moya-Arnao M, Carreras E, Espigado-Tocino I, Pérez-Simón JA
Allocation to Matched Related or Unrelated Donor Results in Similar Clinical Outcomes without Increased Risk of Failure to Proceed to Transplant among Patients with Acute Myeloid Leukemia: A Retrospective Analysis from the Time of Transplant Approval.
Biol Blood Marrow Transplant.
Jiménez-Yuste V, Álvarez-Román MT, Martín-Salces M, De la Corte-Rodríguez H, Altisent C, Parra R, Núñez R, Pérez R, García-Candel F, Bonanad S, Querol F, Alonso N, Fernández-Mosteirín N, López-Ansoar E, García-Frade LJ, Bermejo N, Pérez-González N, Gutiérrez-Pimentel MJ, Martinoli C, Fernández-Arias I, Kim HK
Joint status in Spanish haemophilia B patients assessed using the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score.
Haemophilia.
Batlle J, Pérez-Rodríguez A, Corrales I, Borràs N, Costa Pinto J, López-Fernández MF, Vidal F, PCM-EVW-ES Investigators Team
Update on Molecular Testing in von Willebrand Disease.
Semin Thromb Hemost.
Ribera J, Zamora L, Morgades M, Vives S, Granada I, Montesinos P, Gómez-Seguí I, Mercadal S, Guàrdia R, Nomdedeu J, Pratcorona M, Tormo M, Martínez-Lopez J, Hernández-Rivas JM, Ciudad J, Orfao A, González-Campos J, Barba P, Escoda L, Esteve J, Genescà E, Solé F, Feliu E, Ribera JM, Spanish PETHEMA Group, Spanish Society of Hematology
Molecular profiling refines minimal residual disease-based prognostic assessment in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia.
Genes Chromosomes Cancer.
Caballero JC, Sánchez Barba M, Hernández Sánchez JM, Such E, Janusz K, Sanz G, Cabrero M, Chillón C, Cervera J, Hurtado AM, Jerez A, Calderón Cabrera C, Valcárcel D, Lumbreras E, Abáigar M, López Cadenas F, Hernández Rivas JM, Del Cañizo MC, Díez Campelo M
Chronic graft-versus-host disease could ameliorate the impact of adverse somatic mutations in patients with myelodysplastic syndromes and hematopoietic stem cell transplantation.
Ann Hematol.
Garrastazul-Sánchez MP, Vilches-Moreno M, Fernández-Valle MC, Marchante-Cepillo I, Prats-Martín C, Bernal R, Morales-Camacho RM
Neutrophil faggot cells and inv(16): not such a fortuitous association?
Ann Hematol.
Labrador J, Luño E, Vellenga E, Brunet S, González-Campos J, Chillón MC, Holowiecka A, Esteve J, Bergua J, González-Sanmiguel JD, Gil C, Tormo M, Salamero O, Manso F, Fernández I, de laSerna J, Moreno MJ, Pérez-Encinas M, Krsnik I, Ribera JM, Cervera J, Calasanz MJ, Boluda B, Sobas M, Lowenberg B, Sanz MA, Montesinos P
Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy.
Leuk Lymphoma
Salamero O, Martínez-Cuadrón D, Sobas M, Benavente C, Vives S, De la Serna J, Pérez-Encinas M, Escoda L, Gil C, Brunet S, Ramos F, Esteve J, Amigo M, Krsnik I, Manso F, Arias J, González-Campos J, Serrano J, Oleksiuk J, Barrios M, García-Boyero R, Novo A, Sanz MA, Montesinos P, PETHEMA and PALG Groups
Real life outcomes of patients aged ≥75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry.
Leuk Lymphoma.
Sobas M, Montesinos P, Boluda B, Bernal T, Vellenga E, Nomdedeu J, González-Campos J, Chillón M, Holowiecka A, Esteve J, Bergua J, González-Sanmiguel JD, Gil-Cortes C, Tormo M, Salamero O, Manso F, Fernández I, de la Serna J, Moreno MJ, Pérez-Encinas M, Krsnik I, Ribera JM, Escoda L, Lowenberg B, Sanz MA, PETHEMA, HOVON, PALG, and GATLA cooperative groups
An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens.
Leuk Lymphoma.
Molinos-Quintana A, Trujillo-Hacha P, Piruat JI, Bejarano-García JA, García-Guerrero E, Pérez-Simón JA, Muñoz M
Human acute myeloid leukemia cells express Neurokinin-1 receptor, which is involved in the antileukemic effect of Neurokinin-1 receptor antagonists.
Invest New Drugs.
Barba P, Morgades M, Montesinos P, Gil C, Fox ML, Ciudad J, Moreno MJ, González-Campos J, Genescà E, Martínez-Carballeira D, Martino R, Vives S, Guardia R, Mercadal S, Artola MT, Cladera A, Tormo M, Esteve J, Bergua J, Vall-Llovera F, Ribera J, Martínez-Sanchez P, Amigo ML, Bermúdez A, Calbacho M, Hernández-Rivas JM, Feliu E, Orfao A, Ribera JM
Increased survival due to lower toxicity for high-risk T-cell acute lymphoblastic leukemia patients in two consecutive pediatric-inspired PETHEMA trials.
Eur J Haematol.
García-Cadenas I, Yáñez L, Jarque I, Martino R, Pérez-Simón JA, Valcárcel D, Sanz J, Bermúdez A, Muñoz C, Calderón-Cabrera C, García E, Alonso L, Suárez-Lledó M, González Vicent M, Heras I, Viguria MC, Batlle M, Vázquez L, López J, Solano C, Spanish group of blood and marrow transplantation (GETH)
Frequency, characteristics, and outcome of PTLD after allo-SCT: A multicenter study from the Spanish group of blood and marrow transplantation (GETH).
Eur J Haematol.
Casado-Méndez M, Fernandez-Pacheco J, Arellano-Orden V, Rodríguez-Martorell FJ, Díaz-Martín A, Pastor de Las Heras Á, Dusseck-Brutus R, Pérez-Torres I, Leal-Noval SR
Relationship of thromboelastography and conventional clotting test values with severe bleeding in critically ill patients with coagulopathy: A prospective study.
Int J Lab Hematol.
Martínez-Cuadrón D, Gil C, Serrano J, Rodríguez G, Pérez-Oteyza J, García-Boyero R, Jiménez-Bravo S, Vives S, Vidriales MB, Lavilla E, Pérez-Simón JA, Tormo M, Colorado M, Bergua J, López JA, Herrera P, Hernández-Campo P, Gorrochategui J, Primo D, Rojas JL, Villoria J, Moscardó F, Troconiz I, Linares Gómez M, Martínez-López J, Ballesteros J, Sanz M, Montesinos P, Spanish PETHEMA group
A precision medicine test predicts clinical response after idarubicin and cytarabine induction therapy in AML patients.
Leuk Res.
de Bonilla Damiá Á, Fernández López R, Acevedo Báñez I, Calderón Cabrera C, Molinos Quintana A, Borrego Dorado I
F-FDG PET/CT for extramedullary relapse of acute leukemia of ambiguous lineage.
Rev Esp Med Nucl Imagen Mol.
Garrastazul-Sánchez MP, Vilches-Moreno M, Fernández-Valle C, Marchante-Cepillo I, Prats-Martín C, Bernal R, Morales-Camacho R
Neutrophil faggot cells and inv(16): not such a fortuitous association?
Ann Hematol.
Rodríguez-Otero P, Mateos MV, Martínez-López J, Hernández MT, M. Ocio E, Rosiñol L, Martínez R, Teruel AI, Gutiérrez NC,Bargay J, Bengoechea E, González Y, Pérez de Oteyza J, Gironella M, Nuñez-Córdoba JM, Encinas C, Martín J, Cabrera C, Palomera L, de Arriba F, Cedena MT, Puig N, Oriol A, Paiva B, Bladé J, Lahuerta JJ, San Miguel JF
Predicting long-term disease control in transplant-ineligible patients with multiple myeloma: impact of an MGUS-like signature
Blood Cancer J.
Morales-Camacho RM, Prats-Martín C
Eosinophils with ring-shaped nuclei in a patient treated with adalimumab
Blood.
Colom-Fernández B, Kreutzman A, Marcos-Jiménez A, García-Gutiérrez V, Cuesta-Mateos C, Portero-Sainz I, Pérez-García Y, Casado LF, Sánchez-Guijo F, Martínez-López J, Ayala RM, Boqué C, Xicoy B, Montero I, Soto C, Paz R, Silva G, Vega-Piris L, Steegmann JL, Muñoz-Calleja C
Immediate Effects of Dasatinib on the Migration and Redistribution of Naïve and Memory Lymphocytes Associated With Lymphocytosis in Chronic Myeloid Leukemia Patients
Front Pharmacol.
Ribera J, Zamora L, Morgades M, Vives S, Granada I, Montesinos P, Gomez-Segui I, Mercadal S, Guardia R, Nomdedeu J, Pratcorona M, Tormo M, Martinez-Lopez J, Hernandez-Rivas JM, Ciudad J, Orfao A, Gonzalez-Campos J, Barba P, Escoda L, Esteve J, Genesca E, Sole F, Feliu E, Ribera JM
Molecular profiling refines minimal residual disease-based prognostic assessment in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia
Genes Chromosomes Cancer.
Afram G, Simón JAP, Remberger M, Caballero-Velázquez T, Martino R, Piñana JL, Ringden O, Esquirol A, López-Corral L, García I, López-Godino O, Sierra J, Caballero D, Ljungman P, Vázquez L, Hägglund H.
Reduced intensity conditioning increases risk of severe cGVHD: identification of risk factors for cGVHD in a multicenter setting.
Med Oncol
Aguado-Domínguez E, Sousa JM, Pérez-Simón JA, Aguilera I.
Clinical association of anti-glutathione S-transferase T1 antibodies and de novo immune hepatitis after hematopoietic cell transplantation.
Dig Liver Dis.
Buchrieser J, Oliva-Martín MJ, Moore MD, Long JCD, Cowley SA, Pérez-Simón JA, James W, Venero JL.
RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation.
Cell Death Dis.
Burillo-Sanz S, Morales-Camacho RM, Caballero-Velázquez T, Carrillo E, Sánchez J, Pérez-López O, Pérez de Soto I, González Campos J, Prats-Martín C, Bernal R, Vargas MT.
MLL-rearranged acute myeloid leukemia: Influence of the genetic partner in allo-HSCT response and prognostic factor of MLL 3' region mRNA expression.
Eur J Haematol.
Casado-Méndez M, Arellano-Orden V, Muñoz-Gómez M, Rodríguez-Martorell FJ, Cayuela A, Pastor de Las Heras Á, Díaz Martín A, Pérez Torres I, Leal-Noval SR.
Reliability of the portable coagulometer qLabs to accurately measure the activated thromboplastin time and international normalized ratio: a prospective study in critically ill patients.
Blood Coagul Fibrinolysis.
Falantes JF, Márquez-Malaver FJ, Calderón-Cabrera C, Pedrote B, Martino ML, González J, Espigado I, Pérez-Simón JA.
Evaluation of Parameters Related to the Probability of Leukemic Progression in Patients With Lower-Risk Myelodysplastic Syndrome.
Clin Lymphoma Myeloma Leuk
Ferro M, Mácher HC, Fornés G, Martín-Sánchez J, Jiménez-Arriscado P, Molinero P, Pérez-Simón JA, Guerrero JM, Rubio A.
Noninvasive prenatal diagnosis by cell-free DNA screening for fetomaternal HPA-1a platelet incompatibility.
Transfusion.
García-Calderón CB, Bejarano-García JA, Tinoco-Gago I, Castro MJ, Moreno-Gordillo P, Piruat JI, Caballero-Velázquez T, Pérez-Simón JA, Rosado IV.
Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells.
Cell Death Differ.
García-Guerrero E, Sánchez-Abarca LI, Domingo E, Ramos TL, Bejarano-García JA, González-Campos JA, Caballero-Velázquez T, Pérez-Simón JA.
Selection of Tumor-Specific Cytotoxic T Lymphocytes in Acute Myeloid Leukemia Patients Through the Identification of T-Cells Capable to Establish Stable Interactions With the Leukemic Cells: "Doublet Technology".
Front Immunol
. Genescà E, Lazarenkov A, Morgades M, Berbis G, Ruíz-Xivillé N, Gómez-Marzo P, Ribera J, Juncà J, González-Pérez A, Mercadal S, Guardia R, Artola MT, Moreno MJ, Martínez-López J, Zamora L, Barba P, Gil C, Tormo M, Cladera A, Novo A, Pratcorona M, Nomdedeu J, González-Campos J, Almeida M, Cervera J, Montesinos P, Batlle M, Vives S, Esteve J, Feliu E, Solé F, Orfao A, Ribera JM.
Frequency and clinical impact of CDKN2A/ARF/CDKN2B gene deletions as assessed by in-depth genetic analyses in adult T cell acute lymphoblastic leukemia.
J Hematol Oncol.
González-Molina W, Ávila-Polo R, Morales-Camacho RM, Vargas MT, Bernal R, Prats-Martín C.
Bone marrow erythrocyte and neutrophil phagocytosis and cannibalism by neuroendocrine carcinoma
Br J Haematol.
Gudiol C, Nicolae S, Royo-Cebrecos C, Aguilar-Guisado M, Montero I, Martín-Gandul C, Perayre M, Berbel D, Encuentra M, Arnan M, Cisneros-Herreros JM, Carratalà J.
Administration of taurolidine-citrate lock solution for prevention of central venous catheter infection in adult neutropenic haematological patients: a randomised, double-blinded, placebo-controlled trial (TAURCAT).
Trials.
López-Granados L, Torrent M, Sastre A, González-Vicent M, Díaz de Heredia C, Argilés B, Pascual A, Pérez-Hurtado JM, Sisinni L, Díaz MÁ, Elorza I, Dasí MA, Badell I.
Reduced-intensity conditioning haematopoietic stem cell transplantation in genetic diseases: Experience of the Spanish Working Group for Bone Marrow Transplantation in Children.
An Pediatr (Barc).
López-Millán B, Díaz de la Guardia R, Roca-Ho H, Anguita E, Islam ABMMK, Romero-Moya D, Prieto C, Gutiérrez-Agüera F, Bejarano-García JA, Pérez-Simón JA, Costales P, Rovira M, Marín P, Menéndez S, Iglesias M, Fuster JL, Urbano-Ispizua A, Anjos-Afonso F, Bueno C, Menéndez P.
IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q- AML.
Oncoimmunology
Martínez-Bravo MJ, Sánchez B, Acevedo MJ, Pérez-Simón JA, Núñez-Roldán A, Aguilera I.
De novo recipient-specific Glutathione S-transferase T1 antibody development after HLA-identical hematopoietic cell transplantation.
Transpl Immunol.
Martínez-Cuadrón D, Boluda B, Martínez P, Bergua J, Rodríguez-Veiga R, Esteve J, Vives S, Serrano J, Vidriales B, Salamero O, Cordón L, Sempere A, Jiménez-Ubieto A, Prieto-Delgado J, Díaz-Beyá M, Garrido A, Benavente C, Pérez-Simón JA, Moscardó F, Sanz MA, Montesinos P, CETLAM and PETHEMA groups.
A phase I-II study of plerixafor in combination with fludarabine, idarubicin, cytarabine, and G-CSF (PLERIFLAG regimen) for the treatment of patients with the first early-relapsed or refractory acute myeloid leukemia.
Ann Hematol.
Martínez-Cuadrón D, Montesinos P, Vellenga E, Bernal T, Salamero O, Holowiecka A, Brunet S, Gil C, Benavente C, Ribera JM, Pérez-Encinas M, De la Serna J, Esteve J, Rubio V, González-Campos J, Escoda L, Amutio ME, Arnan M, Arias J, Negri S, Lowënberg B, Sanz MA.
Long-term outcome of older patients with newly diagnosed de novo acute promyelocytic leukemia treated with ATRA plus anthracycline-based therapy.
Leukemia.
Matarraz S, Leoz P, Fernández C, Colado E, Chillón MC, Vidriales MB, González M, Rivera D, Osuna CS, Caballero-Velázquez T, Van Der Velden V, Jongen-Lavrencic M, Gutiérrez O, Bermejo AY, Alonso LG, García MB, De Ramón Sánchez C, García-Donas G, Mateo AG, Recio I, Sánchez-Real J, Mayado A, Gutiérrez ML, Bárcena P, Barrena S, López A, Van Dongen J, Orfao A.
Basophil-lineage commitment in acute promyelocytic leukemia predicts for severe bleeding after starting therapy.
Mod Pathol.
Medrano M, Carrillo-Cruz E, Montero I, Pérez-Simón JA.
Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications.
Int J Mol Sci.
Montalbán C, Díaz-López A, Martín A, Baile M, Sánchez JM, Sancho JM, García O, Novelli S, Monter-Rovira A, Salar A, Bastos M, Gutiérrez A, Bento L, Córdoba R, Arquero T, González de Villambrosia S, Barranco G, De Oña R, López Guillermo A, Rodríguez Salazar MJ, Domínguez JF, Fernández R, Queizan JA, Rodríguez J, Abraira V, García JF, GELTAMO-IPI Project Investigators.
Differential prognostic impact of GELTAMO-IPI in cell of origin subtypes of Diffuse Large B Cell Lymphoma as defined by the Hans algorithm
Br J Haematol.
Morales-Camacho RM, Villanueva-Herraiz S, Prats-Martín C, Borrero JJ, Bernal R, Vargas MT.
Eosinophil phagocytosis in advanced systemic mastocytosis with eosinophilia.
Br J Haematol.
Motlló C, Ribera JM, Morgades M, Granada I, Montesinos P, Mercadal S, González-Campos J, Moreno MJ, Barba P, Cervera M, Barrios M, Novo A, Bernal T, Hernández-Rivas JM, Abella E, Amigo ML, Tormo M, Martino R, Lavilla E, Bergua J, Serrano A, García-Belmonte D, Guàrdia R, Grau J, Feliu E, PETHEMA Group, Spanish Society of Hematology.
Frequency and prognostic significance of additional cytogenetic abnormalities to the Philadelphia chromosome in young and older adults with acute lymphoblastic leukemia.
Leuk Lymphoma
Prats-Martín C, Jiménez-Guerrero P, Morales-Camacho RM, Caballero-Velázquez T, Vargas MT, Pérez O, Montero I, Falantes J, Burillo-Sanz S, Carrillo E, Borrero JJ, Bernal R, Pérez-Simón JA.
KIT D816V- chronic myelomonocytic leukemia progressing to KIT D816V+ associated to mast cell leukemia responding to allogeneic hematopoietic cell transplantation.
Ann Hematol.
Preciado S, Muntión S, Rico A, Pérez-Romasanta LA, Ramos TL, Ortega R, Borrajo J, Corchete LA, Rodríguez C, Díez-Campelo M, Sánchez-Abarca LI, Del Cañizo MC, Sánchez-Guijo F.
Mesenchymal Stromal Cell Irradiation Interferes with the Adipogenic/Osteogenic Differentiation Balance and Improves Their Hematopoietic-Supporting Ability.
Biol Blood Marrow Transplant.
Ribera JM, García O, Gil C, Mercadal S, García-Cadenas I, Montesinos P, Barba P, Vives S, González-Campos J, Tormo M, Esteve J, López A, Moreno MJ, Ribera J, Alonso N, Bermúdez A, Amigo ML, Genescà E, García D, Vall-Llovera F, Bergua JM, Guàrdia R, Monteserín MC, Bernal T, Calbacho M, Martínez MP, Feliu E, PETHEMA Group.
Comparison of intensive, pediatric-inspired therapy with non-intensive therapy in older adults aged 55-65 years with Philadelphia chromosome-negative acute lymphoblastic leukemia.
Leuk Res
Ribera JM, Morgades M, Montesinos P, Martino R, Barba P, Soria B, Bermúdez A, Moreno MJ, González-Campos J, Vives S, Gil C, Abella E, Guàrdia R, Martínez-Carballeira D, Martínez-Sánchez P, Amigo ML, Mercadal S, Serrano A, López-Martínez A, Vall-Llovera F, Sánchez-Sánchez MJ, Peñarrubia MJ, Calbacho M, Méndez JA, Bergua J, Cladera A, Tormo M, García-Belmonte D, Feliu E, Ciudad J, Orfao A, PETHEMA Group, Spanish Society of Hematology.
Efficacy and safety of native versus pegylated Escherichia coli asparaginase for treatment of adults with high-risk, Philadelphia chromosome-negative acute lymphoblastic leukemia.
Leuk Lymphoma.
. Rodríguez-Arbolí E, Morales-Camacho RM, Prats-Martín C, Vargas MT, Montero MI, Bernal R.
Severe granulocytic dysplasia with vacuolar rosettes in a myelodysplastic syndrome with low-copy KMT2A gain
Br J Haematol.
Rodríguez-Barbosa JI, Ferreras MC, Buhler L, Jones ND, Schneider P, Pérez-Simón JA, Del Río ML.
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation.
MAbs
Rodríguez-Gil A, Riedlinger T, Ritter O, Saul VV, Schmitz ML.
Formaldehyde-assisted Isolation of Regulatory Elements to Measure Chromatin Accessibility in Mammalian Cells.
J Vis Exp
Rodríguez-Otero P, Mateos MV, Martínez-López J, Martín-Calvo N, Hernández MT, Ocio EM, Rosiñol L, Martínez R, Teruel AI, Gutiérrez NC, Bargay J, Bengoechea E, González Y, de Oteyza JP, Gironella M, Encinas C, Martín J, Cabrera C, Palomera L, de Arriba F, Cedena MT, Paiva B, Puig N, Oriol A, Bladé J, Lahuerta JJ, San Miguel JF.
Early myeloma-related death in elderly patients: development of a clinical prognostic score and evaluation of response sustainability role.
Leukemia.
Rojas-Martínez JA, Morales-Camacho RM.
Internuclear bridging outside of primary myelodysplasia and congenital dyserythropoietic anemia.
Blood.
Sánchez-García J, Falantes J, Medina Pérez A, Hernández-Mohedo F, Hermosín L, Torres-Sabariego A, Bailén A, Hernández-Sánchez JM, Solé Rodríguez M, Casaño FJ, Calderón C, Labrador M, Vahí M, Serrano J, Lumbreras E, Hernández-Rivas JM, Grupo Andaluz SMD.
Prospective randomized trial of 5 days azacitidine versus supportive care in patients with lower-risk myelodysplastic syndromes without 5q deletion and transfusion-dependent anemia.
Leuk Lymphoma.
Santos N, Rodríguez-Romanos R, de la Cámara R, Brunet S, Nieto JB, Buño I, Martínez C, Jiménez-Velasco A, Vallejo C, González M, Solano C, Ferrá C, Sampol A, Pérez-Simón JA, López-Jiménez J, Díez JL, Gallardo D, GvHD/Immunotherapy Working Party of the Spanish Group of Hematopoietic Transplant (GETH).
PD-1 genotype of the donor is associated with acute graft-versus-host disease after HLA-identical sibling donor stem cell transplantation.
Ann Hematol.
Barzaghi F, Amaya Hernández LC, Neven B, Ricci S, Kucuk ZY, Bleesing JJ, Nademi Z, Slatter MA, Ulloa ER, Shcherbina A, Roppelt A, Worth A, Silva J, Aiuti A, Murguia-Favela L, Speckmann C, Carneiro-Sampaio M, Fernandes JF, Baris S, Ozen A, Karakoc-Aydiner E, Kiykim A, Schulz A, Steinmann S, Notarangelo LD, Gambineri E, Lionetti P, Shearer WT, Forbes LR, Martínez C, Moshous D, Blanche S, Fisher A, Ruemmele FM, Tissandier C, Ouachee-Chardin M, Rieux-Laucat F, Cavazzana M, Qasim W, Lucarelli B, Albert MH, Kobayashi I, Alonso L, Díaz De Heredia C, Kanegane H, Lawitschka A, Seo JJ, González-Vicent M, Díaz MA, Goyal RK, Sauer MG, Yesilipek A, Kim M, Yilmaz-Demirdag Y, Bhatia M, Khlevner J, Richmond Padilla EJ, Martino S, Montin D, Neth O, Molinos-Quintana A, Valverde-Fernández J, Broides A, Pinsk V, Ballauf A, Haerynck F, Bordon V, Dhooge C, García-Lloret ML, Bredius RG, Kałwak K, Haddad E, Seidel MG, Duckers G, Pai SY, Dvorak CC, Ehl S, Locatelli F, Goldman F, Gennery AR, Cowan MJ, Roncarolo MG, Bacchetta R, Primary Immune Deficiency Treatment Consortium (PIDTC) and the Inborn Errors Working Party (IEWP) of the European Society for Blood and Marrow Transplantation (EBMT).
Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study.
J Allergy Clin Immunol.
Aguilar-Guisado M, Espigado I, Martín-Peña A, Gudiol C, Royo-Cebrecos C, Falantes J, Vázquez-López L, Montero MI, Rosso-Fernández C, de la Luz Martino M, Parody R, González-Campos J, Garzón-López S, Calderón-Cabrera C, Barba P, Rodríguez N, Rovira M, Montero-Mateos E, Carratalá J, Pérez-Simón JA, Cisneros JM.
Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial.
Lancet Haematol
. Almeida AM, Prebet T, Itzykson R, Ramos F, Al-Ali H, Shammo J, Pinto R, Maurillo L, Wetzel J, Musto P, Van De Loosdrecht AA, Costa MJ, Esteves S, Burgstaller S, Stauder R, Autzinger EM, Lang A, Krippl P, Geissler D, Falantes JF, Pedro C, Bargay J, Deben G, Garrido A, Bonanad S, Díez-Campelo M, Thepot S, Ades L, Sperr WR, Valent P, Fenaux P, Sekeres MA, Greil R, Pleyer L.
Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study.
Int J Mol Sci.
Barbado MV, Medrano M, Caballero-Velázquez T, Álvarez-Laderas I, Sánchez-Abarca LI, García-Guerrero E, Martín-Sánchez J, Rosado IV, Piruat JI, González-Naranjo P, Campillo NE, Páez JA, Pérez-Simón JA.
Cannabinoid derivatives exert a potent anti-myeloma activity both in vitro and in vivo.
Int J Cancer.
Burgos-Barragan G, Wit N, Meiser J, Dingler FA, Pietzke M, Mulderrig L, Pontel LB, Rosado IV, Brewer TF, Cordell RL, Monks PS, Chang CJ, Vázquez A, Patel KJ.
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
Nature.
Burillo-Sanz S, Vargas MT, Morales-Camacho RM, Caballero-Velázquez T, Sánchez J, García-Lozano JR, Pérez de Soto I, Prats-Martín C, Bernal R, Pérez-Simón JA.
RUNX1 amplification in AML with myelodysplasia-related changes and ring 21 chromosomes.
Hematol Oncol
Cornely OA, Leguay T, Maertens J, Vehreschild MJGT, Anagnostopoulos A, Castagnola C, Verga L, Rieger C, Kondakci M, Härter G, Duarte RF, Allione B, Cordonnier C, Heussel CP, Morrissey CO, Agrawal SG, Donnelly JP, Bresnik M, Hawkins MJ, Garner W, Gökbuget N, AmBiGuard Study Group.
Randomized comparison of liposomal amphotericin B versus placebo to prevent invasive mycoses in acute lymphoblastic leukaemia.
J Antimicrob Chemother.
Del Río ML, Bravo Moral AM, Fernández-Renedo C, Buhler L, Pérez-Simón JA, Chaloin O, Álvarez Nogal R, Fernández-Caso M, Rodríguez-Barbosa JI.
Modulation of cytotoxic responses by targeting CD160 prolongs skin graft survival across major histocompatibility class I barrier.
Transl Res
Falantes JF, Márquez-Malaver FJ, Knight T, Calderón-Cabrera C, Martino ML, González J, Montero I, Espigado I, Pérez-Simón JA.
The incorporation of comorbidities in the prognostication of patients with lower-risk myelodysplastic syndrome.
Leuk Lymphoma.
Gallardo D, Bosch-Vizcaya A, Rodríguez-Romanos R, Santos N, Buño I, de la Cámara R, Brunet S, Jiménez-Velasco A, González M, Nieto JB, Martínez-Laperche C, Vallejo C, Ferrá C, Sampol A, López-Jiménez J, Pérez-Simón JA, Martínez C, Díez JL, GvHD/Immunotherapy Committee of the Spanish Hematopoietic Transplant Group.
Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches
Biol Blood Marrow Transplant.
García-Guerrero E, Gogishvili T, Danhof S, Schreder M, Pallaud C, Pérez-Simón JA, Einsele H, Hudecek M.
Panobinostat induces CD38 upregulation and augments the antimyeloma efficacy of daratumumab.
Blood.
Garderet L, Cook G, Auner HW, Bruno B, Lokhorst H, Pérez-Simón JA, Sahebi F, Scheid C, Morris C, van Biezen A, Sobh M, Michallet M, Gahrton G, Schönland S, Kröger N. .
Treatment options for relapse after autograft in multiple myeloma - report from an EBMT educational meeting.
Leuk Lymphoma
Kharfan-Dabaja MA, Parody R, Perkins J, López-Godino O, López-Corral L, Vázquez L, Caballero D, Falantes J, Shapiro J, Ortí G, Barba P, Valcárcel D, Esquirol A, Martino R, Piñana JL, Solano C, Tsalatsanis A, Pidala J, Anasetti C, Pérez-Simón JA. B
Tacrolimus plus sirolimus with or without ATG as GVHD prophylaxis in HLA-mismatched unrelated donor allogeneic stem cell transplantation.
one Marrow Transplant
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ.
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment
Med Clin (Barc)
. Morado M, Freire Sandes A, Colado E, Subirá D, Isusi P, Soledad Noya M, Belén Vidriales M, Sempere A, Ángel Díaz J, Minguela A, Álvarez B, Serrano C, Caballero T, Rey M, Pérez Corral A, Cristina Fernández Jiménez M, Magro E, Lemes A, Benavente C, Bañas H, Merino J, Castejón C, Gutiérrez O, Rabasa P, Vescosi Gonçalves M, Pérez-Andrés M, Orfao A, PNH working group of the Iberian Society of Cytometry (SIC).
Diagnostic screening of paroxysmal nocturnal hemoglobinuria: Prospective multicentric evaluation of the current medical indications
Cytometry B Clin Cytom.
Morales-Camacho RM, Serrano-Chacón MD, Prats-Martín C, Vargas MT, Bernal R, Burillo-Sanz S.
Platelet phagocytosis by granulopoietic precursors in a myelodysplastic syndrome overexpressing the P-selectin gene.
Br J Haematol.
Nomdedeu M, Pereira A, Ramos F, Valcárcel D, Costa D, Arnan M, Calvo X, Pomares H, Luño E, Díaz-Campelo M, Collado R, de Paz R, Falantes JF, Pedro C, Marco J, Oirtzabal I, Sánchez-García J, Tormo M, Cedena MT, Nomdedeu B, Sanz G, Spanish MDS Group.
Excess mortality in the myelodysplastic syndromes
Am J Hematol.
Ostos FJ, Lebrón JA, Moyá ML, López-López M, Sánchez A, Clavero A, García-Calderón CB, Rosado IV, López-Cornejo P.
P-Sulfocalix[6]arene as Nanocarrier for Controlled Delivery of Doxorubicin
Chem Asian J.
Pérez-Moreno JJ, Espina-Zambrano AG, García-Calderón CB, Estrada B.
Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction.
J Cell Sci.
Prats-Martín C, Franco-Macías E, Morales-Camacho RM, Pérez O, Vargas MT, de la Cruz Vicente F, Borrero JJ, Bernal R, Pérez-Simón JA.
Intravascular lymphoma: look through the small vessels
Ann Hematol.
Prats-Martín C, Morales-Camacho RM.
Circulating hypergranular neoplastic cells: not always leukemic promyelocytes
Blood.
Sánchez R, Ayala R, Alonso RA, Martínez MP, Ribera J, García O, Sánchez-Pina J, Mercadal S, Montesinos P, Martino R, Barba P, González-Campos J, Barrios M, Lavilla E, Gil C, Bernal T, Escoda L, Abella E, Amigo ML, Moreno MJ, Bravo P, Guàrdia R, Hernández-Rivas JM, García-Guiñón A, Piernas S, Ribera JM, Martínez-López J.
Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive acute lymphoblastic leukemia: the importance of characterizing ABL1 mutations in cerebrospinal fluid.
Ann Hematol.
Sarmiento Maldonado M, Ramírez Villanueva P, Bertín Cortes-Monroy P, Jara Arias V, Soto Donoso K, Uribe González P, Ocqueteau Tachini M, Pérez-Simón JA.
Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis.
Exp Hematol Oncol.
Seymour JF, Döhner H, Butrym A, Wierzbowska A, Selleslag D, Jang JH, Kumar R, Cavenagh J, Schuh AC, Candoni A, Récher C, Sandhu I, Del Castillo TB, Al-Ali HK, Falantes J, Stone RM, Minden MD, Weaver J, Songer S, Beach CL, Dombret H.
Azacitidine improves clinical outcomes in older patients with acute myeloid leukaemia with myelodysplasia-related changes compared with conventional care regimens.
BMC Cancer
Verdesoto-Cozzarelli S, Prats-Martín C, Morales-Camacho RM, Pérez de Soto C, Ruiz M, de Blas JM, Bernal R, Pérez-Simón JA.
Candida parapsilosis misleading the automated absolute and differential white blood cell count
Ann Hematol.
Villegas A, Núñez R, Gaya A, Cuevas-Ruiz MV, Bosch JM, Carral A, Arrizabalaga B, Gómez-Roncero MI, Mora A, Bravo P, Lavilla E, Monteserín C, Hernández B, Martínez-Barranco P, Jarque I, Urquía MA, García-Donas G, Brunet S, González FA, Urbano Á.
Presence of acute and chronic renal failure in patients with paroxysmal nocturnal hemoglobinuria: results of a retrospective analysis from the Spanish PNH Registry
Ann Hematol
Ashtekar A, Huk D, Magner A, La Perle K, Zhang X, Piruat JI, López-Barneo J, Jhiang SM, Kirschner LS.
Sdhd ablation promotes thyroid tumorigenesis by inducing a stem-like phenotype.
Endocr Relat Cancer.
Merlo A, Bernardo-Castiñeira C, Sáenz-de-Santa-María I, Pitiot AS, Balbín M, Astudillo A, Valdés N, Scola B, Del Toro R, Méndez-Ferrer S, Piruat JI, Suarez C, Chiara MD.
Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate
Oncotarget
Ramos TL, Sánchez-Abarca LI, Rosón-Burgo B, Redondo A, Rico A, Preciado S, Ortega R, Rodríguez C, Muntión S, Hernández-Hernández Á, De Las Rivas J, González M, González Porras JR, Del Cañizo C, Sánchez-Guijo F.
Mesenchymal stromal cells (MSC) from JAK2+ myeloproliferative neoplasms differ from normal MSC and contribute to the maintenance of neoplastic hematopoiesis.
PLoS One.
Ramos TL, Sánchez-Abarca LI, Redondo A, Hernández-Hernández Á, Almeida AM, Puig N, Rodríguez C, Ortega R, Preciado S, Rico A, Muntión S, Porras JRG, Del Cañizo C, Sánchez-Guijo F.
HDAC8 overexpression in mesenchymal stromal cells from JAK2+ myeloproliferative neoplasms: a new therapeutic target?
Oncotarget.
Martínez-Carrasco R, Sánchez-Abarca LI, Nieto-Gómez C, García EM, Ramos TL, Velasco A, Sánchez-Guijo F, Aijón J, Hernández-Galilea E
Assessment of dry eye in a GVHD murine model: Approximation through tear osmolarity measurement
Exp Eye Res.
Books and articles in books
Falantes J, Pleyer L, Thépot S, Almeida AM, Maurillo L, Martínez-Robles V, Stauder R, Itzykson R, Pinto R, Venditti A, Bargay J, Burgstaller S, Martínez MP, Seegers V, Cortesão E, Foncillas MÁ, Gardin C, Montesinos P, Musto P, Fenaux P, Greil R, Sanz MA, Ramos F, European ALMA + Investigators.
Real life experience with frontline azacitidine in a large series of older adults with acute myeloid leukemia stratified by MRC/LRF score: results from the expanded international E-ALMA series (E-ALMA+).
Leuk Lymphoma
Ribera JM, Morgades M, Montesinos P, Martino R, Barba P, Soria B, Bermúdez A, Moreno MJ, González-Campos J, Vives S, Gil C, Abella E, Guàrdia R, Martínez-Carballeira D, Martínez-Sánchez P, Amigo ML, Mercadal S, Serrano A, López-Martínez A, Vall-Llovera F, Sánchez-Sánchez MJ, Peñarrubia MJ, Calbacho M, Méndez JA, Bergua J, Cladera A, Tormo M, García-Belmonte D, Feliu E, Ciudad J, Orfao A, PETHEMA Group, Spanish Society of Hematology.
Efficacy and safety of native versus pegylated Escherichia coli asparaginase for treatment of adults with high-risk, Philadelphia chromosome-negative acute lymphoblastic leukemia.
Leuk Lymphoma.