Oncohematology and Genetics

Molecular Biology of Cancer

Amancio Carnero Moya
Amancio Carnero Moya
IBiS
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla

Laboratory: 214

Amancio Carnero Moya

Back to program
  1. Group members
  2. Research areas
  3. Publications

Group: Molecular Biology of Cancer

Directory
Group members Molecular Biology of Cancer
  • Blanco Alcaina, Elena.Investigadora Predoctoral
  • Carnero Moya, Amancio.PhD in Biology. Staff Scientist (CSIC).
  • Chaves Conde, Manuel.Doctor en Medicina. Facultativo clínico
  • Clemente González, Cynthia.Investigadora Predoctoral
  • Espinosa Sánchez, Asunción .Investigadora Predoctoral. Beca AECC.
  • Estévez García, Purificación.Degree in Medicine. Oncologist (Río Hortega).
  • Fuentes Pradera, José.FEA HUV Valme
  • García Heredia, José Manuel.Profesor ayudante doctor en Bioquímica
  • Marín López, Juan José.PhD in Biology. Assistant Professor (University of Seville).
  • Muñoz Galván, Sandra.PhD in Biology. Post-doctoral fellow.
  • Navas Maldonado, Lola Eufemia.Investigadora en Formación
  • Ortega Campos, Sara María.Investigadora Predoctural
  • Peinado Serrano, Javier.Ldo. en Medicina
  • Sánchez Díaz, Laura.Lda. en Biomedicina básica y experimental
  • Suárez Martínez, Elisa.Lda. en Biomedicina. Predoctoral.
  • Vázquez Gutiérrez, Inmaculada.Contratada FPI
  • Verdugo Sivianes, Eva Mª.Investigadora en Formación. Doctora en Biología Molecular

Research areas

The research lines in this laboratory are:

  • Identification and characterization of genes with therapeutic relevance in cancer.
  • Establishing causality in the initiation and progression of the tumoral process.
  • Validation of new therapeutic targets that could form the basis for the identification of new anti-tumor compounds.
International Journals
Martin-Broto, J; Hindi, N; Lopez-Pousa, A; Peinado-Serrano, J; Alvarez, R; Alvarez-Gonzalez, A; Italiano, A; Sargos, P; Cruz-Jurado, J; Isern-Verdum, J; Dolado, MC; Rincon-Perez, I; Sanchez-Bustos, P; Gutierrez, A; Romagosa, C; Morosi, C; Grignani, G; Gatti, M; Luna, P; Alastuey, I; Redondo, A; Belinchon, B; Martinez-Serra, J; Sunyach, MP; Coindre, JM; Dei Tos, AP; Romero, J; Gronchi, A; Blay, JY; Moura, DS
Assessment of Safety and Efficacy of Combined Trabectedin and Low-Dose Radiotherapy for Patients With Metastatic Soft-Tissue Sarcomas A Nonrandomized Phase 1/2 Clinical Trial
JAMA ONCOLOGY
Cayuela, L; Lendinez-Cano, G; Chavez-Conde, M; Rodriguez-Dominguez, S; Cayuela, A
Recent trends in prostate cancer in Spain
ACTAS UROLOGICAS ESPANOLAS
Macias-Garcia, L; Martinez-Ballesteros, M; Luna-Romera, JM; Garcia-Heredia, JM; Garcia-Gutierrez, J; Riquelme-Santos, JC
Autoencoded DNA methylation data to predict breast cancer recurrence: Machine learning models and gene-weight significance
ARTIFICIAL INTELLIGENCE IN MEDICINE
Quintanal-Villalonga, A; Ferrer, I; Guruceaga, E; Cirauqui, C; Marrugal, A; Ojeda, L; Garcia, S; Zugazagoitia, J; Munoz-Galvan, S; Lopez-Rios, F; Montuenga, L; Vicent, S; Molina-Pinelo, S; Carnero, A; Paz-Ares, L
FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy
EBIOMEDICINE
Garcia-Heredia, JM; Otero-Albiol, D; Perez, M; Perez-Castejon, E; Munoz-Galvan, S; Carnero, A
Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells
ONCOGENESIS
Perez, M; Garcia-Heredia, JM; Felipe-Abrio, B; Munoz-Galvan, S; Martin-Broto, J; Carnero, A
Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment
SIGNAL TRANSDUCTION AND TARGETED THERAPY
Marques, M; Tranchant, R; Risa-Ebri, B; Suarez-Solis, ML; Fernandez, LC; Carrillo-de-Santa-Pau, E; Del Pozo, N; de Villarreal, JM; Meiller, C; Allory, Y; Blum, Y; Pirker, C; Hegedus, B; Barry, ST; Carnero, A; Berger, W; Jean, D; Real, FX
Combined MEK and PI3K/p110 beta Inhibition as a Novel Targeted Therapy for Malignant Mesothelioma Displaying Sarcomatoid Features
CANCER RESEARCH
Munoz-Galvan, S; Felipe-Abrio, B; Verdugo-Sivianes, EM; Perez, M; Jimenez-Garcia, MP; Suarez-Martinez, E; Estevez-Garcia, P; Carnero, A
Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness
MOLECULAR CANCER
Perez-Martinez, L; Romero, L; Munoz-Galvan, S; Verdugo-Sivianes, EM; Rubio-Mediavilla, S; Oteo, JA; Carnero, A; Blanco, JR
Implications of maraviroc and/or rapamycin in a mouse model of fragility
AGING-US
Espinosa-Sanchez, A; Suarez-Martinez, E; Sanchez-Diaz, L; Carnero, A
Therapeutic Targeting of Signaling Pathways Related to Cancer Stemness
FRONTIERS IN ONCOLOGY
Marin-Barrera, L; Munoz-Martin, AJ; Rios-Herranz, E; Garcia-Escobar, I; Beato, C; Font, C; Oncala-Sibajas, E; Revuelta-Rodriguez, A; Areses, MC; Rivas-Jimenez, V; Moreno-Santos, MA; Ballaz-Quincoces, A; Lopez-Saez, JB; Gallego, I; Elias-Hernandez, T; Asensio-Cruz, MI; Chasco-Eguilaz, L; Garcia-Gonzalez, G; Estevez-Garcia, P; Otero, R; Lima-Alvarez, J; Jara-Palomares, L
A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study
CANCERS
Felipe-Abrio, B; Carnero, A
The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness
CANCERS
Munoz-Galvan, S; Rivero, M; Peinado-Serrano, J; Martinez-Perez, J; Fernandez-Fernandez, MC; Ortiz, MJ; Garcia-Heredia, JM; Carnero, A
PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208
CELLS
Munoz-Galvan, S; Carnero, A
Targeting Cancer Stem Cells to Overcome Therapy Resistance in Ovarian Cancer
CELLS
Garcia-Heredia, JM; Carnero, A
Role of Mitochondria in Cancer Stem Cell Resistance
CELLS
Lopez-Medina, EM; Sainz, T; de Ory, SJ; Mellado-Pena, MJ; Gonzalez-Tome, MI; Gil, EC; Cucurull, TV; Neyra, F; Frick, MA; Martinez-Perez, J; Andres, AGA; Alonso, MB; Laleona, CG; Hernandez, MM; Hernandez, PC; Amador, JTR; Gomez, MLN; Santiago-Garcia, B
Tuberculosis in a Spanish cohort of children living with HIV: the CHOTIS study (Childhood HIV & TB study)
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
Ferrer I, Quintanal-Villalonga Á, Molina-Pinelo S, García-Heredia JM, Pérez M, Suárez R, Ponce-Aix S, Paz-Ares L, Carnero A
MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma.
. J Exp Clin Cancer Res.
García-Heredia JM, Carnero A.
Dr. Jekyll and Mr. Hyde: MAP17's up-regulation, a crosspoint in cancer and inflammatory diseases
Mol Cancer.
Lucena-Cacace A, Otero-Albiol D, Jiménez-García MP, Muñoz-Galván S, Carnero A.
NAMPT Is a Potent Oncogene in Colon Cancer Progression that Modulates Cancer Stem Cell Properties and Resistance to Therapy through Sirt1 and PARP.
Clin Cancer Res.
Molina-Pinelo S, Salinas A, Moreno-Mata N, Ferrer I, Suárez R, Andrés-León E, Rodríguez-Paredes M, Gutekunst J, Jantus-Lewintre E, Camps C, Carnero A, Paz-Ares L.
Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer.
Oncotarget
Quintanal-Villalonga Á, Mediano M, Ferrer I, Meléndez R, Carranza-Carranza A, Suárez R, Carnero A, Molina-Pinelo S, Paz-Ares L.
Histology-dependent prognostic role of pERK and p53 protein levels in early-stage non-small cell lung cancer.
Oncotarget
Quintanal-Villalonga Á, Ojeda-Márquez L, Marrugal Á, Yagüe P, Ponce-Aix S, Salinas A, Carnero A, Ferrer I, Molina-Pinelo S, Paz-Ares L.
The FGFR4-388arg Variant Promotes Lung Cancer Progression by N-Cadherin Induction.
Sci Rep
Pachón Ibáñez J, Pereira Cunill JL, Osorio Gómez GF, Irles Rocamora JA, Serrano Aguayo P, Quintana Ángel B, Fuentes Pradera J, Chaves Conde M, Ortiz Gordillo MJ, García Luna PP.
Prevention of oral mucositis secondary to antineoplastic treatments in head and neck cancer by supplementation with oral glutamine
Nutr Hosp.
García-Heredia JM, Carnero A.
NUMB and NUMBL differences in gene regulation.
Oncotarget
Rivero M, Peinado-Serrano J, Muñoz-Galván S, Espinosa-Sánchez A, Suárez-Martínez E, Felipe-Abrio B, Fernández-Fernández MC, Ortiz MJ, Carnero A.
MAP17 (PDZK1IP1) and pH2AX are potential predictive biomarkers for rectal cancer treatment efficacy.
Oncotarget.
García-Heredia JM, Lucena-Cacace A, Verdugo-Sivianes EM, Pérez M, Carnero A.
The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB.
Clin Cancer Res.
García-Heredia JM, Carnero A.
The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
Oncotarget.
Jiménez-García MP, Lucena-Cacace A, Robles-Frías MJ, Ferrer I, Narlik-Grassow M, Blanco-Aparicio C, Carnero A.
Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.
Oncotarget
Lucena-Cacace A, Otero-Albiol D, Jiménez-García MP, Peinado-Serrano J, Carnero A.
NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis
Oncotarget.
Martín-Broto J, Redondo A, Valverde C, Vaz MA, Mora J, García Del Muro X, Gutiérrez A, Tous C, Carnero A, Marcilla D, Carranza A, Sancho P, Martínez-Trufero J, Díaz-Beveridge R, Cruz J, Encinas V, Tarón M, Moura DS, Luna P, Hindi N, López-Pousa A.
Gemcitabine plus sirolimus for relapsed and progressing osteosarcoma patients after standard chemotherapy: a multicenter, single-arm phase II trial of Spanish Group for Research on Sarcoma (GEIS).
Ann Oncol.
Verdugo-Sivianes EM, Navas L, Molina-Pinelo S, Ferrer I, Quintanal-Villalonga A, Peinado J, García-Heredia JM, Felipe-Abrio B, Muñoz-Galván S, Marín JJ, Montuenga L, Paz-Ares L, Carnero A.
Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer.
Oncotarget
Martínez-Pérez J, López-Calderero I, Sáez C, Benavent M, Limón ML, González-Expósito R, Soldevilla B, Riesco-Martínez MC, Salamanca J, Carnero A, García-Carbonero R.
Prognostic relevance of Src activation in stage II-III colon cancer
Hum Pathol.
Guijarro MV, Carnero A.
Genome-Wide miRNA Screening for Genes Bypassing Oncogene-Induced Senescence
Methods Mol Biol