Neurociencias

Neurovascular

Joan Montaner Villalonga
Joan Montaner Villalonga
IBiS
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla
Laboratorio: 112

Joan Montaner Villalonga

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  1. Miembros del grupo
  2. Áreas de trabajo
  3. Publicaciones
  4. Actualidad

Grupo: Neurovascular

Directorio
Miembros del grupo Neurovascular
  • Acevedo Aguilera, Rosa.Lda. en Enfermería
  • Acosta López, María José.Técnico de Apoyo
  • Ainz Gómez, Leire.Licenciada en Medicina. FEA HUVR
  • Albóniga-Chindurza Barroeta, Asier.Licenciado en Medicina. FEA HUVR
  • Barragán Prieto, Ana.Licenciada en Medicina. FEA HUVR
  • Boyero Corral, Sofía.Lda. en Medicina y Cirugía
  • Cabezas Rodríguez, Juan Antonio.Neurólogo, HUV Rocío
  • De la Torre Laviana, Javier.Neurólogo, HUV Rocío
  • de Torres Chacón, Mª Reyes.Neuróloga, HUV Macarena
  • del Río Mercado, Carmen.Investigadora Juan de la Cierva
  • Domínguez Mayoral, Ana María.Neuróloga, HUV Macarena
  • Escudero Martínez, Irene Mª .Neuróloga, HUV Rocío
  • Fernández Santos, Beatriz María.Lda. en Bioquímica
  • Fuerte Hortigón, Alejandro.MIR HUVR
  • Gamero Garcia, Miguel Angel.Neurólogo, HUV Macarena
  • González García, Alejandro.Doctor en Medicina, Neurorradiólogo, HUV Rocío
  • Lebrato Hernández, Lucía.Neuróloga, HUV Rocío
  • Loscertales Castaños, Juan.FEA HUVM
  • Mancha Molina , Fernando.Doctor en Biología. Bioquímico clínico.
  • Medina Rodríguez, Manuel.Grado en Medicina
  • Menéndez Valladares, Paloma.FEA HUVM. Doctora en Bioquímica
  • Moniche Álvarez, Francisco.Doctor en Medicina. Neurólogo, HUV Rocío
  • Montaner Villalonga , Joan.Investigador Responsable. Neurólogo, Jefe de Servicio
  • Morales Bravo, María.Diplomada en Estadística
  • Moreno Pujol, Jose.Estadístico
  • Ocete Pérez, Rafael Félix.Neurorradiólogo, HUV Rocío
  • Ortega Quintanilla, Joaquín.
  • Pardo Galiana, Blanca.MIR Neurología.
  • Peña Vallejo, María Jesús.Diplomada en Enfermería
  • Pérez Sánchez, Soledad.Doctor en Medicina. Neuróloga, HUV Macarena
  • Reyes Corral, Marta.Lda. en Biotecnología. Doctora en Biología del Cáncer
  • Rivero Caballero, María José.Lda. en Biología
  • Sánchez Toril, Silvia.Técnico de Apoyo
  • Sempere Bores, Lluis.Doctor en Biología
  • Urbano Sánchez, Cristina.Lda. en Ingeniería de la Salud
  • Ybot González, Patricia.Lda. en Biología. Doctora en Biología Molecular
  • Zamora Piñero, Aynara.Técnico de Apoyo
  • Zapata Arriaza, Elena.Neuróloga Intervencionista, HUV Rocío

Áreas de trabajo

Nuestro grupo acaba de echar a volar gracias al proyecto ITRIBIS con la idea de potenciar la investigación neurovascular en Andalucía. Nuestras líneas aún no están plenamente definidas y han de surgir de 8 proyectos científicos que desarrollaremos en los próximos meses para explorar distintos aspectos traslacionales del ictus, desde identificar poblaciones diana de altísimo riesgo vascular en las que hacer prevención mediante estrategias de nutrición,  a estudiar los fenómenos de daño vascular desde el pequeñísimo vaso cerebral que produce micro-infartos corticales al gran vaso estenótico. Una vez que el ictus se produce pretendemos llevar el “hospital a casa” (ambulancias-high-tech, POCs, telemedicina-móvil, etc) y mejorar los aspectos de la neuroprotección post-isquemia, aprovechando el enorme know-how del IBiS en hipoxia para caracterizar y modular los mecanismos de sensado de O2 de los distintos componentes de la unidad neurovascular. Nuestra investigación clínica se basará en estudios multicéntricos de intervención (prevención de infecciones tras el ictus; administración precoz de progenitores de médula ósea, etc).

Revistas Internacionales
Palacios-Mendoza, MA; Pastor, AG; Gil-Nunez, A; Ramirez-Moreno, JM; Gonzalez-Nafria, N; Moniche, F; Portilla-Cuenca, JC; Fuentes, B; Gamero-Garcia, MA; de Lecinana, MA; Masjuan, J; Verge, DC; Aladro, Y; Lago, A; de Arce-Borda, AM; Usero-Ruiz, M; Delgado-Mederos, R; Pampliega, A; Ximenez-Carrillo, A; Bartulos-Iglesias, M; Castro-Reyes, E
Ultrasonographic and hemodynamic characteristics of patients with symptomatic carotid near-occlusion: results from a multicenter registry study
NEURORADIOLOGY
Garcia-Pastor, A; Gil-Nunez, A; Ramirez-Moreno, JM; Gonzalez-Nafria, N; Tejada, J; Moniche, F; Portilla-Cuenca, JC; Martinez-Sanchez, P; Fuentes, B; Gamero-Garcia, MA; de Lecinana, MA; Canovas-Verge, D; Aladro, Y; Lago-Martin, A; de Arce-Borda, AM; Usero-Ruiz, M; Arenillas, JF; Delgado-Mederos, R; Pampliega, A; Ximenez-Carrillo, A; Bartulos-Iglesias, M; Castro-Reyes, E
Comment on the article "Symptomatic carotid near-occlusion causes a high risk of recurrent ipsilateral ischemic stroke" by Gu et al.
JOURNAL OF NEUROLOGY
Escudero-Martinez, I; Ocete, RF; Mancha, F; Vega, A; Pinero, P; Lopez-Rueda, A; Fajardo, E; Algaba, P; Fernandez-Engo, JR; Martin-Sanchez, EM; Galvao-Carmona, A; Zapata-Arriaza, E; Lebrato, L; Pardo-Galiana, B; Cabezas, JA; Ayuso, MI; Gonzalez, A; Moniche, F; Montaner, J
Prevalence and risk factors of silent brain infarcts in patients with AF detected by 3T-MRI
JOURNAL OF NEUROLOGY
Muino, E; Bustamante, A; Rodriguez-Campello, A; Gallego-Fabrega, C; Ois, A; Carrera, C; Cullell, N; Torres-Aguila, N; Carcel-Marquez, J; Rubiera, M; Molina, CA; Cuadrado-Godia, E; Giralt-Steinhauer, E; Jimenez-Conde, J; Montaner, J; Fernandez-Cadenas, I; Roquer, J
A parsimonious score with a free web tool for predicting disability after an ischemic stroke: the Parsifal Score
JOURNAL OF NEUROLOGY
Lim, ST; Thijs, V; Murphy, SJX; Fernandez-Cadenas, I; Montaner, J; Offiah, C; Marquardt, L; Kelly, PJ; Bath, PM; Lim, SY; Ford, GA; Norrving, B; Cox, D; Prodan, CI; Barber, PA; Werring, DJ; Perry, R; Zgaga, L; Dawson, J; McCabe, DJH
Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis
JOURNAL OF NEUROLOGY
Afifi, K; Bellanger, G; Buyck, PJ; Zuurbier, SM; Esperon, CG; Barboza, MA; Costa, P; Escudero, I; Renard, D; Lemmens, R; Hinteregger, N; Fazekas, F; Conde, JJ; Giralt-Steinhauer, E; Hiltunen, S; Arauz, A; Pezzini, A; Montaner, J; Putaala, J; Weimar, C; Schlamann, M; Gattringer, T; Tatlisumak, T; Coutinho, JM; Demaerel, P; Thijs, V
Features of intracranial hemorrhage in cerebral venous thrombosis
JOURNAL OF NEUROLOGY
Pala, E; Bustamante, A; Jolkkonen, J; Hommel, M; Rosell, A; Montaner, J
Blood-based biomarkers and stem cell therapy in human stroke: a systematic review
MOLECULAR BIOLOGY REPORTS
Fragata, I; Bustamante, A; Penalba, A; Ferreira, P; Nunes, AP; Canhao, P; Montaner, J
TNF-R1 Correlates with Cerebral Perfusion and Acute Ischemia Following Subarachnoid Hemorrhage
NEUROCRITICAL CARE
Garcia-Berrocoso, T; Pala, E; Consegal, M; Piccardi, B; Negro, A; Gill, N; Penalba, A; Encabo, HH; Fernandez-Cadenas, I; Meisel, A; Meisel, C; Jickling, GC; Munoz, MA; Clua-Espuny, JL; Pedrote, A; Pagola, J; Juega, J; Bustamante, A; Montaner, J
Cardioembolic Ischemic Stroke Gene Expression Fingerprint in Blood: a Systematic Review and Verification Analysis
TRANSLATIONAL STROKE RESEARCH
Pagola, J; Juega, J; Francisco-Pascual, J; Bustamante, A; Penalba, A; Pala, E; Rodriguez, M; De Lera-Alfonso, M; Arenillas, JF; Cabezas, JA; Moniche, F; de Torres, R; Montaner, J; Gonzalez-Alujas, T; Alvarez-Sabin, J; Molina, CA
Predicting Atrial Fibrillation with High Risk of Embolization with Atrial Strain and NT-proBNP
TRANSLATIONAL STROKE RESEARCH
Rubio-Rivas, M; Corbella, X; Guillen-del-Castillo, A; Vilella, CT; Arguelles, DC; Argibay, A; Hitos, JAV; Parra, JAT; Gonzalez-Echavarri, C; Ortego-Centeno, N; Martinez, LT; Carballeira, MR; Ballve, AM; Salas, XP; Fraile, IP; Chamorro, AJ; Vuelta, ABM; Freire, M; Munoz, MR; Garcia, AG; del Campo, IPM; Garcia, MES; Bello, DB; Espinosa, G; Hernandez, FJG; Comet, LS; Blanco, JJR; Gimenez, RAFD; Trigo, SS; Pla, VF; Aznar, CPS
Spanish scleroderma risk score (RESCLESCORE) to predict 15-year all-cause mortality in scleroderma patients at the time of diagnosis based on the RESCLE cohort: Derivation and internal validation
AUTOIMMUNITY REVIEWS
Fuerte-Hortigon, A; Perez-Noguera, R; Garcia-Soto, JD; Boronat, IR; de Andres, SA; Garcia-Moreno, JM
Novel CACNA1A variant may cause cervical dystonia and cerebellar ataxia syndrome
JOURNAL OF THE NEUROLOGICAL SCIENCES
Ramiro, L; Simats, A; Penalba, A; Garcia-Tornel, A; Rovira, A; Mancha, F; Bustamante, A; Montaner, J
Circulating Aquaporin-4 as A biomarker of early neurological improvement in stroke patients: A pilot study
NEUROSCIENCE LETTERS
Sanchez, SP; Noguera, RP; Sanchez, VS; Dominguez, JML
Anti-Hu associated paraneoplastic neuropathy simulating an axonal variant of Guillain-Barre syndrome
NEUROLOGIA
Macias-Garcia, D; Serrano, JJ; Blazquez, MJP; Moniche, F
Acute lower limb paresis in a patient with rheumatoid arthritis: Emergency neuroimaging findings
NEUROLOGIA
de Alboniga-Chindurza, A; Ortega-Quintanilla, J; Alcalde-Lopez, J; Zapata-Arriaza, E; Gonzalez, A
Intra-arterial gadolinium as an alternative to iodinated contrast agent in thrombectomy
NEUROLOGIA
Ruiz, JMO; Dos Subira, L; Garcia, AG; Soriano, JR; Alonso, PA; Gallego, P
Adult congenital heart disease in Spain: health care structure and activity, and clinical characteristics
REVISTA ESPANOLA DE CARDIOLOGIA
Montaner, J; Ramiro, L; Simats, A; Tiedt, S; Makris, K; Jickling, GC; Debette, S; Sanchez, JC; Bustamante, A
Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke
NATURE REVIEWS NEUROLOGY
Cullell, N; Carrera, C; Muino, E; Torres-Aguila, NP; Carcel-Marquez, J; Gonzalez-Sanchez, J; Gallego-Fabrega, C; Molina, J; Besora, S; Sotoca, J; Buongiorno, MT; Jimenez-Conde, J; Giralt-Steinhauer, E; de Torres-Chacon, R; Montaner, J; Mancha, F; Cabezas, JA; Marti-Fabregas, J; Prats-Sanchez, L; Camps-Renom, P; Purroy, F; Cambray, S; Freijo, MD; Vives-Bauz, C; Tur, S; Font, MA; Lopez-Cancio, E; Hernandez-Perez, M; Obach, V; Calleja, A; Arenillas, J; Rodriguez-Yanez, M; Castillo, J; Sobrino, T; Fernandez-Cadenas, I; Krupinski, J
Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain
SCIENTIFIC REPORTS
Menendez-Valladares, P; Sola-Idigora, N; Fuerte-Hortigon, A; Alonso-Perez, I; Duque-Sanchez, C; Dominguez-Mayoral, AM; Ybot-Gonzalez, P; Montaner, J
Lessons learned from proteome analysis of perinatal neurovascular pathologies
EXPERT REVIEW OF PROTEOMICS
Soriano-Tarraga, C; Lazcano, U; Giralt-Steinhauer, E; Avellaneda-Gomez, C; Ois, A; Rodriguez-Campello, A; Cuadrado-Godia, E; Gomez-Gonzalez, A; Fernandez-Sanles, A; Elosua, R; Fernandez-Cadenas, I; Cullell, N; Montaner, J; Moran, S; Esteller, M; Jimenez-Conde, J
Identification of 20 novel loci associated with ischaemic stroke. Epigenome-wide association study
EPIGENETICS
Pagola, J; Juega, J; Francisco-Pascual, J; Bustamante, A; Penalba, A; Pala, E; Rodriguez, M; Alfonso, MD; Arenillas, JF; Cabezas, JA; Moniche, F; de Torres, R; Montaner, J; Gonzalez-Alujas, T; Alvarez-Sabin, J; Molina, CA
Large vessel occlusion is independently associated with atrial fibrillation detection
EUROPEAN JOURNAL OF NEUROLOGY
Pala, E; Pagola, J; Juega, J; Francisco-Pascual, J; Bustamante, A; Penalba, A; Comas, I; Rodriguez, M; Alfonso, MD; Arenillas, JF; de Torres, R; Perez-Sanchez, S; Cabezas, JA; Moniche, F; Gonzalez-Alujas, T; Molina, CA; Montaner, J
B-type natriuretic peptide over N-terminal pro-brain natriuretic peptide to predict incident atrial fibrillation after cryptogenic stroke
EUROPEAN JOURNAL OF NEUROLOGY
Escudero-Martinez, I; Mazya, M; Teutsch, C; Lesko, N; Gdovinova, Z; Barbarini, L; Fryze, W; Karlinski, M; Kobayashi, A; Krastev, G; Nunes, AP; Pasztoova, K; Peeters, A; Sobolewski, P; Vilionskis, A; Toni, D; Ahmed, N
Dabigatran initiation in patients with non-valvular AF and first acute ischaemic stroke: a retrospective observational study from the SITS registry
BMJ OPEN
Mancha, F; Escudero-Martinez, I; Zapata-Arriaza, E; Vega-Salvatierra, A; Cabezas, JA; Lebrato, L; Pardo, B; De-La-Torre, J; Zapata, M; Escamilla, V; Calderon-Cabrera, C; Martin-Sanchez, J; Valverde, R; Aguera-Morales, E; Herrera, I; Delgado, F; Gamero, MA; Perez-Sanchez, S; Moya, M; Espinosa, R; Ortega-Quintanilla, J; Gutierrez-Jarrin, I; Gonzalez-Garcia, A; Montaner, J; Moniche, F
Circulating microRNA after autologous bone marrow mononuclear cell (BM-MNC) injection in patients with ischemic stroke
JOURNAL OF INVESTIGATIVE MEDICINE
Gonzalez, A; Ortega-Quintanilla, J; Zapata-Arriaza, E; de Alboniga-Chindurza, A; Garcia-Lozano, JR; Vega, MIL; Cayuela, A
Dose adjustment of clopidogrel in hyper-responder patients with unruptured intracranial aneurysms treated with stents
JOURNAL OF NEUROINTERVENTIONAL SURGERY
Garcia-Pastor, A; Gil-Nunez, A; Ramirez-Moreno, JM; Gonzalez-Nafria, N; Tejada, J; Moniche, F; Portilla-Cuenca, JC; Martinez-Sanchez, P; Fuentes, B; Gamero-Garcia, MA; de Lecinana, MA; Masjuan, J; Canovas, D; Aladro, Y; Parkhutik, V; Lago, A; De Arce, AM; Usero-Ruiz, M; Delgado-Mederos, R; Pampliega, A; Ximenez-Carrillo, A; Bartulos-Iglesias, M; Castro-Reyes, E
Progression of carotid near-occlusion to complete occlusion: related factors and clinical implications
JOURNAL OF NEUROINTERVENTIONAL SURGERY
Medina-Rodriguez, M; Millan-Vazquez, M; Zapata-Arriaza, E; Escudero, I; Pardo-Galiana, B; Cabezas-Rodriguez, JA; Lebrato-Hernandez, L; Ortega-Quintanilla, J; de Alboniga-Chindurza, A; Ocete-Perez, RF; Jurado-Serrano, J; Gonzalez-Garcia, A; Cayuela, A; Moniche, F
Intravenous Thrombolysis Guided by Perfusion CT with Alteplase in > 4.5 Hours from Stroke Onset
CEREBROVASCULAR DISEASES
Thoren, M; Dixit, A; Escudero-Martinez, I; Gdovinova, Z; Klecka, L; Rand, VM; Toni, D; Vilionskis, A; Wahlgren, N; Ahmed, N
Effect of Recanalization on Cerebral Edema in Ischemic Stroke Treated With Thrombolysis and/or Endovascular Therapy
STROKE
Montaner, J; Barragan-Prieto, A; Perez-Sanchez, S; Escudero-Martinez, I; Moniche, F; Sanchez-Miura, JA; Ruiz-Bayo, L; Gonzalez, A
Break in the Stroke Chain of Survival due to COVID-19
STROKE
Perez-Sanchez, S; Dominguez-Mayoral, A; De Torres-Chacon, R; Gamero-Garcia, MA; Barragan-Prieto, A; Escudero-Martinez, I; Ocete, RF; Herrero-Lara, J; Algaba, P; Moniche, F; Gonzalez, A; Cueto, L; Montaner, J
Cervical dissection diagnoses increase following endovascular treatments
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Misra, S; Montaner, J; Ramiro, L; Arora, R; Talwar, P; Nath, M; Kumar, A; Kumar, P; Pandit, AK; Mohania, D; Prasad, K; Vibha, D
Blood biomarkers for the diagnosis and differentiation of stroke: A systematic review and meta-analysis
INTERNATIONAL JOURNAL OF STROKE
Hotter, B; Hoffmann, S; Ulm, L; Montaner, J; Bustamante, A; Meisel, C; Meisel, A
Inflammatory and stress markers predicting pneumonia, outcome, and etiology in patients with stroke Biomarkers for predicting pneumonia, functional outcome, and death after stroke
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
Elkind, MSV; Veltkamp, R; Montaner, J; Johnston, SC; Singhal, AB; Becker, K; Lansberg, MG; Tang, WH; Kasliwal, R; Elkins, J
Natalizumab in acute ischemic stroke (ACTION II) A randomized, placebo-controlled trial
NEUROLOGY
Lillicrap, T; Keragala, CB; Draxler, DF; Chan, J; Ho, HD; Harman, S; Niego, B; Holliday, E; Levi, CR; Garcia-Esperon, C; Spratt, N; Gyawali, P; Bivard, A; Parsons, MW; Montaner, J; Bustamante, A; Cadenas, IF; Cloud, G; Maguire, JM; Lincz, L; Kleinig, T; Attia, J; Koblar, S; Hamilton-Bruce, MA; Choi, P; Worrall, BB; Medcalf, RL
Plasmin Generation Potential and Recanalization in Acute Ischaemic Stroke
FRONTIERS IN NEUROLOGY
Martinez-Alonso, E; Escobar-Peso, A; Ayuso, MI; Gonzalo-Gobernado, R; Chioua, M; Montoya, JJ; Montaner, J; Fernandez, I; Marco-Contelles, J; Alcazar, A
Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke
ANTIOXIDANTS
Perez-Sanchez, S; Barragan-Prieto, A; Ortega-Quintanilla, J; Dominguez-Mayoral, A; Gamero-Garcia, MA; Zapata-Arriaza, E; de Torres-Chacon, R; de Alboniga-Chindurza, A; Zapata-Hidalgo, M; Moniche, F; Escudero-Martinez, I; Baena, P; Cabezas, JA; Oropesa-Ruiz, JM; Sanz-Fernandez, G; Gonzalez, A; Montaner, J
Sex Differences by Hospital-Level in Performance and Outcomes of Endovascular Treatment for Acute Ischemic Stroke
JOURNAL OF STROKE
Moniche, F; Escudero-Martinez, I; Mancha, F; Tomasello, A; Ribo, M; Delgado-Acosta, F; Ochoa, JJ; Gil, J; Gil, R; Gonzalez-Delgado, M; Murias, E; Luna, A; Gil, A; Mosteiro, S; Fernandez-Couto, MD; de Alarcon, LF; Ramirez-Moreno, JM; Zamarro, J; Parrilla, G; Caniego, JL; Zapata-Wainberg, G; Gonzalez-Mandly, A; de las Heras, JA; Lopez-Mesonero, L; Ortega, J; Arenillas, JF; Garcia, E; Alcazar, PP; Zapata-Arriaza, E; de Alboniga-Chindurza, A; Cabezas, JA; Algaba, P; Cayuela, A; Montaner, J; Garcia, AG
The Value of Transcranial Doppler Sonography in Hyperperfusion Syndrome after Carotid Artery Stenting: A Nationwide Prospective Study
JOURNAL OF STROKE
Cabezas, JA; Bustamante, A; Giannini, N; Pecharroman, E; Katsanos, AH; Tsivgoulis, G; Rozanski, M; Audebert, H; Mondello, S; Llombart, V; Montaner, J
Discriminative value of glial fibrillar acidic protein (GFAP) as a diagnostic tool in acute stroke. Individual patient data meta-analysis
JOURNAL OF INVESTIGATIVE MEDICINE
Mola-Caminal M, Carrera C, Soriano-Tárraga C, Giralt-Steinhauer E, Díaz-Navarro RM, Tur S, Jiménez C, Medina-Dols A, Cullell N, Torres-Aguila NP, Muiño E, Rodríguez-Campello A, Ois A, Cuadrado-Godia E, Vivanco-Hidalgo RM, Hernandez-Guillamon M, Solé M, Delgado P, Bustamante A, García-Berrocoso T, Mendióroz M, Castellanos M, Serena J, Martí-Fàbregas J, Segura T, Serrano-Heras G, Obach V, Ribó M, Molina CA, Alvarez-Sabín J, Palomeras E, Freijo M, Font MA, Rosand J, Rost NS, Gallego-Fabrega C, Lee JM, Heitsch L, Ibanez L, Cruchaga C, Phuah CL, Lemmens R, Thijs V, Lindgren A, Maguire J, Rannikmae K, Sudlow CL, Jern C, Stanne TM, Lorentzen E, Muñoz-Narbona L, Dávalos A, López-Cancio E, Worrall BB, Woo D, Kittner SJ, Mitchell BD, Montaner J, Roquer J, Krupinski J, Estivill X, Rabionet R, Vives-Bauzá C, Fernández-Cadenas I, Jiménez-Conde J
PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome.
Circ Res.
Marini S, Crawford K, Morotti A, Lee MJ, Pezzini A, Moomaw CJ, Flaherty ML, Montaner J, Roquer J, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano-Tarraga C, Slowik A, Jagiella JM, Pera J, Urbanik A, Pichler A, Hansen BM, McCauley JL, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Testai FD, Kittner SJ, Schmidt H, Enzinger C, Deary IJ, Rannikmae K, Samarasekera N, Salman RA, Sudlow CL, Klijn CJM, van Nieuwenhuizen KM, Fernandez-Cadenas I, Delgado P, Norrving B, Lindgren A, Goldstein JN, Viswanathan A, Greenberg SM, Falcone GJ, Biffi A, Langefeld CD, Woo D, Rosand J, Anderson CD, International Stroke Genetics Consortium
Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.
JAMA Neurol.
González García A, Moniche F, Escudero-Martínez I, Mancha F, Tomasello A, Ribó M, Delgado-Acosta F, Ochoa JJ, de Las Heras JA, López-Mesonero L, González-Delgado M, Murias E, Gil J, Gil R, Zamarro J, Parrilla G, Mosteiro S, Fernández-Couto MD, Fernández de Alarcón L, Ramírez-Moreno JM, Luna A, Gil A, González-Mandly A, Caniego JL, Zapata-Wainberg G, García E, Alcázar PP, Ortega J, Arenillas JF, Algaba P, Zapata-Arriaza E, Alcalde-López J, de Albóniga-Chindurza A, Cayuela A, Montaner J
Clinical Predictors of Hyperperfusion Syndrome Following Carotid Stenting: Results From a National Prospective Multicenter Study.
JACC Cardiovasc Interv.
Buyck PJ, Zuurbier SM, Garcia-Esperon C, Barboza MA, Costa P, Escudero I, Renard D, Lemmens R, Hinteregger N, Fazekas F, Conde JJ, Giralt-Steinhauer E, Hiltunen S, Arauz A, Pezzini A, Montaner J, Putaala J, Weimar C, Churilov L, Gattringer T, Asadi H, Tatlisumak T, Coutinho JM, Demaerel P, Thijs V
Diagnostic accuracy of noncontrast CT imaging markers in cerebral venous thrombosis.
Neurology.
Carrera C, Cullell N, Torres-Águila N, Muiño E, Bustamante A, Dávalos A, López-Cancio E, Ribó M, Molina CA, Giralt-Steinhauer E, Soriano-Tárraga C, Mola-Caminal M, Jiménez-Conde J, Roquer J, Vives-Bauza C, Navarro RD, Obach V, Arenillas JF, Segura T, Serrano-Heras G, Martí-Fàbregas J, Freijo M, Cabezas JA, Tatlisumak T, Heitsch L, Ibañez L, Cruchaga C, Lee JM, Strbian D, Montaner J, Fernández-Cadenas I, Spanish Stroke Genetic Consortium
Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA.
Neurology
Chioua M, Martínez-Alonso E, Gonzalo-Gobernado R, Ayuso MI, Escobar-Peso A, Infantes L, Hadjipavlou-Litina D, Montoya JJ, Montaner J, Alcázar A, Marco-Contelles J
New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( Z)- N- tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment.
J Med Chem.
Ibanez L, Heitsch L, Dube U, Farias FHG, Budde J, Bergmann K, Davenport R, Bradley J, Carrera C, Kinnunen J, Sallinen H, Strbian D, Slowik A, Fernandez-Cadenas I, Montaner J, Lee JM, Cruchaga C
Overlap in the Genetic Architecture of Stroke Risk, Early Neurological Changes, and Cardiovascular Risk Factors.
Stroke.
García-Berrocoso T, Palà E, Consegal M, Piccardi B, Negro A, Gill N, Penalba A, Huerga Encabo H, Fernández-Cadenas I, Meisel A, Meisel C, Jickling GC, Muñoz MÁ, Clúa-Espuny JL, Pedrote A, Pagola J, Juega J, Bustamante A, Montaner J
Cardioembolic Ischemic Stroke Gene Expression Fingerprint in Blood: a Systematic Review and Verification Analysis.
Transl Stroke Res.
Escudero-Martínez I, Mancha F, Vega-Salvatierra Á, Ayuso MI, Ocete RF, Algaba P, López-Rueda A, Piñero P, Fajardo E, Fernández-Engo JR, Martín-Sánchez EM, Galvao-Carmona A, Zapata-Arriaza E, Lebrato L, Pardo-Galiana B, Cabezas JA, González A, Moniche F, Montaner J
Mediterranean Diet and Physical Activity Protect from Silent Brain Infarcts in a Cohort of Patients with Atrial Fibrillation.
J Stroke.
Torres-Aguila NP, Carrera C, Muiño E, Cullell N, Cárcel-Márquez J, Gallego-Fabrega C, González-Sánchez J, Bustamante A, Delgado P, Ibañez L, Heitsch L, Krupinski J, Montaner J, Martí-Fàbregas J, Cruchaga C, Lee JM, Fernandez-Cadenas I, Acute Endophenotypes Group of the International Stroke Genetics Consortium (ISGC)
Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review.
J Stroke.
Zapata-Arriaza E, Serrano-Gotarredona P, Navarro-Herrero S, Moniche F, Pardo-Galiana B, Pallisa E, Vega-Salvatierra Á, Mancha F, Escudero-Martínez I, Bustamante A, Montaner J
Chest Computed Tomography Findings and Validation of Clinical Criteria of Stroke Associated Pneumonia.
J Stroke.
Zapata-Arriaza E, Mancha F, Bustamante A, Moniche F, Pardo-Galiana B, Serrano-Gotarredona P, Navarro-Herrero S, Pallisa E, Faura J, Vega-Salvatierra Á, Penalba A, Escudero-Martínez I, Ramos-Herrero VD, Azurmendi L, Charles Sanchez J, Montaner J
Biomarkers predictive value for early diagnosis of Stroke-Associated Pneumonia.
Ann Clin Transl Neurol.
García-Pastor A, Gil-Núñez A, Ramírez-Moreno JM, González-Nafría N, Tejada J, Moniche F, Portilla-Cuenca JC, Martínez-Sánchez P, Fuentes B, Gamero-García MÁ, Alonso de Leciñana M, Masjuán J, Cánovas-Verge D, Aladro Y, Parkhutik V, Lago-Martín A, de Arce-Borda AM, Usero-Ruíz M, Delgado-Mederos R, Pampliega A, Ximenez-Carrillo Á, Bártulos-Iglesias M, Castro-Reyes E, Stroke Project of the Spanish Cerebrovascular Diseases Study Group
The risk of recurrent stroke at 24 months in patients with symptomatic carotid near-occlusion: results from CAOS, a multicentre registry study.
Eur J Neurol.
Gonzalo-Gobernado R, Ayuso MI, Sansone L, Bernal-Jiménez JJ, Ramos-Herrero VD, Sánchez-García E, Ramos TL, Abia R, Muriana FJG, Bermúdez B, Montaner J
Neuroprotective Effects of Diets Containing Olive Oil and DHA/EPA in a Mouse Model of Cerebral Ischemia.
Nutrients.
Mangin G, Cogo A, Moisan A, Bonnin P, Maïer B, Kubis N, RESSTORE Consortium
Intravenous Administration of Human Adipose Derived-Mesenchymal Stem Cells Is Not Efficient in Diabetic or Hypertensive Mice Subjected to Focal Cerebral Ischemia.
Front Neurosci.
Fragata I, Bustamante A, Penalba A, Ferreira P, Nunes AP, Canhão P, Montaner J
Venous and arterial TNF-R1 predicts outcome and complications in acute subarachnoid hemorrhage.
Neurocrit Care
López-Escobar B, Wlodarczyk BJ, Caro-Vega J, Lin Y, Finnell RH, Ybot-González P
The interaction of maternal diabetes with mutations that affect folate metabolism and how they affect the development of neural tube defects in mice.
Dev Dyn.
Palà E, Bustamante A, Clúa-Espuny JL, Acosta J, Gonzalez-Loyola F, Ballesta-Ors J, Gill N, Caballero A, Pagola J, Pedrote A, Muñoz MA, Montaner J
N-Terminal Pro B-Type Natriuretic Peptide's Usefulness for Paroxysmal Atrial Fibrillation Detection Among Populations Carrying Cardiovascular Risk Factors.
Front Neurol.
Smith CJ, Heal C, Vail A, Jeans AR, Westendorp WF, Nederkoorn PJ, van de Beek D, Kalra L, Montaner J, Woodhead M, Meisel A
Antibiotic Class and Outcome in Post-stroke Infections: An Individual Participant Data Pooled Analysis of VISTA-Acute.
Front Neurol
Cayuela A, Cayuela L, Ortega Belmonte MJ, Rodríguez-Domínguez S, Escudero-Martínez I, González A
Has stroke mortality stopped declining in Spain?
Neurologia.
Cayuela A, Cayuela L, Rodríguez-Domínguez S, González A, Moniche F
Analysis of cerebrovascular disease mortality trends in Andalusia (1980-2014).
Neurologia.
Ahmed N, Audebert H, Turc G, Cordonnier C, Christensen H, Sacco S, Sandset EC, Ntaios G, Charidimou A, Toni D, Pristipino C, Köhrmann M, Kuramatsu JB, Thomalla G, Mikulik R, Ford GA, Martí-Fàbregas J, Fischer U, Thoren M, Lundström E, Rinkel GJ, van der Worp HB, Matusevicius M, Tsivgoulis G, Milionis H, Rubiera M, Hart R, Moreira T, Lantz M, Sjöstrand C, Andersen G, Schellinger P, Kostulas K, Sunnerhagen KS, Keselman B, Korompoki E, Purrucker J, Khatri P, Whiteley W, Berge E, Mazya M, Dippel DW, Mustanoja S, Rasmussen M, Söderqvist ÅK, Escudero-Martínez I, Steiner T
Consensus statements and recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 11-13 November 2018.
Eur Stroke J.
Kishore AK, Jeans AR, Garau J, Bustamante A, Kalra L, Langhorne P, Chamorro A, Urra X, Katan M, Napoli MD, Westendorp W, Nederkoorn PJ, van de Beek D, Roffe C, Woodhead M, Montaner J, Meisel A, Smith CJ
Antibiotic treatment for pneumonia complicating stroke: Recommendations from the pneumonia in stroke consensus (PISCES) group.
Eur Stroke J
. Kasner SE, Swaminathan B, Lavados P, Sharma M, Muir K, Veltkamp R, Ameriso SF, Endres M, Lutsep H, Messé SR, Spence JD, Nedeltechev K, Perera K, Santo G, Olavarría V, Lindgren A, Bangdiwala S, Shoamanesh A, Berkowitz SD, Mundl H, Connolly SJ, Hart RG; NAVIGATE ESUS Investigators.
Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.
Lancet Neurol.
Contreras Muruaga MM, Reig G, Vivancos J, González A, Cardona P, Ramírez-Moreno JM, Martí-Fábregas J, Suárez Fernández C; en nombre de los investigadores del estudio ALADIN; Listado de investigadores del estudio ALADIN.
Factors associated with poor anticoagulation control with vitaminK antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study.
Rev Clin Esp
Lagerstedt L, Egea-Guerrero JJ, Bustamante A, Rodríguez-Rodríguez A, El Rahal A, Quintana-Díaz M, García-Armengol R, Prica CM, Andereggen E, Rinaldi L, Sarrafzadeh A, Schaller K, Montaner J, Sanchez JC.
Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury.
PLoS One.
Hart RG, Sharma M, Mundl H, Kasner SE, Bangdiwala SI, Berkowitz SD, Swaminathan B, Lavados P, Wang Y, Wang Y, Davalos A, Shamalov N, Mikulik R, Cunha L, Lindgren A, Arauz A, Lang W, Czlonkowska A, Eckstein J, Gagliardi RJ, Amarenco P, Ameriso SF, Tatlisumak T, Veltkamp R, Hankey GJ, Toni D, Bereczki D, Uchiyama S, Ntaios G, Yoon BW, Brouns R, Endres M, Muir KW, Bornstein N, Ozturk S, O'Donnell MJ, De Vries Basson MM, Pare G, Pater C, Kirsch B, Sheridan P, Peters G, Weitz JI, Peacock WF, Shoamanesh A, Benavente OR, Joyner C, Themeles E, Connolly SJ; NAVIGATE ESUS Investigators.
Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source.
N Engl J Med.
Alcalde-López J, Zapata-Arriaza E, Cayuela A, Moniche F, Escudero-Martínez I, Ortega-Quintanilla J, de Torres-Chacón R, Montaner J, Mayol A, González A.
Safety of Early Carotid Artery Stenting for Symptomatic Stenosis in Daily Practice.
Eur J Vasc Endovasc Surg.
Fernández G, Moraga A, Cuartero MI, García-Culebras A, Peña-Martínez C, Pradillo JM, Hernández-Jiménez M, Sacristán S, Ayuso MI, Gonzalo-Gobernado R, Fernández-López D, Martín ME, Moro MA, González VM, Lizasoain I.
TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models.
Mol Ther.
Kishore AK, Vail A, Jeans AR, Chamorro A, Di Napoli M, Kalra L, Langhorne P, Roffe C, Westendorp W, Nederkoorn PJ, Garau J, van de Beek D, Montaner J, Woodhead M, Meisel A, Smith CJ, Pneumonia in Stroke Consensus (PISCES) Group.
Microbiological Etiologies of Pneumonia Complicating Stroke: A Systematic Review
Stroke.
Lagerstedt L, Egea-Guerrero JJ, Rodríguez-Rodríguez A, Bustamante A, Montaner J, El Rahal A, Andereggen E, Rinaldi L, Sarrafzadeh A, Schaller K, Sanchez JC.
Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury.
PLoS One
Pagola J, Juega J, Francisco-Pascual J, Moya A, Sanchís M, Bustamante A, Penalba A, Usero M, Cortijo E, Arenillas JF, Calleja AI, Sandín-Fuentes M, Rubio J, Mancha F, Escudero-Martínez I, Moniche F, de Torres R, Pérez-Sánchez S, González-Matos CE, Vega Á, Pedrote AA, Arana-Rueda E, Montaner J, Molina CA, CryptoAF investigators.
Yield of atrial fibrillation detection with Textile Wearable Holter from the acute phase of stroke: Pilot study of Crypto-AF registry.
Int J Cardiol.
Zapata-Arriaza E, Moniche F, Blanca PG, Bustamante A, Escudero-Martínez I, Uclés O, Ollero-Ortiz Á, Sánchez-García JA, Gamero MÁ, Quesada Á, Vidal De Francisco D, Romera M, De la Cruz C, Sanz G, Montaner J.
External Validation of the ISAN, A2DS2, and AIS-APS Scores for Predicting Stroke-Associated Pneumonia.
J Stroke Cerebrovasc Dis
Zapata-Wainberg G, Quintas S, Ximénez-Carrillo Rico Á, Masjuán Vallejo J, Cardona P, Castellanos Rodrigo M, Benavente Fernández L, García Pastor A, Egido J, Maciñeiras J, Serena J, Freijo Guerrero MDM, Moniche F, Vivancos J.
Epidemiology of Intracranial Hemorrhage Associated with Oral Anticoagulants in Spain: Trends in Anticoagulation Complications Registry - The TAC 2 Study
Interv Neurol.
Ayuso MI, Gonzalo-Gobernado R, Montaner J.
Neuroprotective diets for stroke.
Neurochem Int.
Ayuso MI, Martínez-Alonso E, Chioua M, Escobar-Peso A, Gonzalo-Gobernado R, Montaner J, Marco-Contelles J, Alcázar A.
Quinolinyl Nitrone RP19 Induces Neuroprotection after Transient Brain Ischemia.
ACS Chem Neurosci.
Bustamante A, García-Berrocoso T, Penalba A, Giralt D, Simats A, Muchada M, Zapata E, Rubiera M, Montaner J.
Sepsis biomarkers reprofiling to predict stroke-associated infections
J Neuroimmunol.
Cayuela A, Cayuela L, Rodríguez-Domínguez S, González A, Moniche F.
Analysis of cerebrovascular disease mortality trends in Andalusia (1980-2014).
Neurologia.
Delgado F, Bravo I, Jiménez E, Murías E, Saiz A, Vega P, López-Rueda A, Blasco J, Macho J, González A.
Endovascular treatment in the acute and non-acute phases of carotid dissection: a therapeutic approach.
J Neurointerv Surg
Domínguez-Mayoral A, Gutiérrez C, López-Domínguez JM, Eichau S, Abril J, Navarro-Mascarell G, Quesada-García MA, Ramos M, Álvarez-López M, Menéndez-De León C, Izquierdo G.
Atypical Guillain-Barre syndrome clustering: is it necessary to reconsider the diagnostic criteria and microbiological protocol?
Rev Neurol.
Elkins J, Veltkamp R, Montaner J, Johnston SC, Singhal AB, Becker K, Lansberg MG, Tang W, Chang I, Muralidharan K, Gheuens S, Mehta L, Elkind MSV.
Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial.
Lancet Neurol.
Fernández-Cadenas I, Mendióroz M, Giralt D, Nafria C, García E, Carrera C, Gallego-Fabrega C, Domingues-Montanari S, Delgado P, Ribó M, Castellanos M, Martínez S, Freijo M, Jiménez-Conde J, Rubiera M, Álvarez-Sabín J, Molina CA, Font MA, Grau Olivares M, Palomeras E, Pérez de la Ossa N, Martinez-Zabaleta M, Masjuan J, Moniche F, Canovas D, Piñana C, Purroy F, Cocho D, Navas I, Tejero C, Aymerich N, Cullell N, Muiño E, Serena J, Rubio F, Dávalos A, Roquer J, Arenillas JF, Martí-Fábregas J, Keene K, Chen WM, Worrall B, Sale M, Arboix A, Krupinski J, Montaner J, GRECOS Study Group.
GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke
Stroke.
García-Pastor A, Gil-Núñez A, Ramírez-Moreno JM, González-Nafría N, Tejada J, Moniche F, Portilla-Cuenca JC, Martínez-Sánchez P, Fuentes B, Gamero-García MÁ, Alonso de Leciñana M, Cánovas-Verge D, Aladro Y, Parkhutik V, Lago-Martín A, de Arce-Borda AM, Usero-Ruíz M, Delgado-Mederos R, Pampliega A, Ximénez-Carrillo Á, Bártulos-Iglesias M, Castro-Reyes E, Stroke Project of the Spanish Cerebrovascular Diseases Study Group.
Early risk of recurrent stroke in patients with symptomatic carotid near-occlusion: Results from CAOS, a multicenter registry study.
Int J Stroke.
Hinman JD, Rost NS, Leung TW, Montaner J, Muir KW, Brown S, Arenillas JF, Feldmann E, Liebeskind DS.
Principles of precision medicine in stroke.
J Neurol Neurosurg Psychiatry.
Lagerstedt L, Egea-Guerrero JJ, Bustamante A, Montaner J, Rodríguez-Rodríguez A, El Rahal A, Turck N, Quintana M, García-Armengol R, Prica CM, Andereggen E, Rinaldi L, Sarrafzadeh A, Schaller K, Sánchez JC.
H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury.
PLoS One.
Zapata-Arriaza E, Pardo-Galiana B, González-García A, Montaner Villalonga J.
Intravenous thrombolysis and thrombectomy in young patients with ischaemic stroke due to undetected atrial myxoma: Do recent clinical trials provide sufficient evidence to support reperfusion in these cases?
Neurologia.
Libros y artículos en libros
Torres-Aguila NP, Carrera C, Giese AK, Cullell N, Muiño E, Cárcel-Márquez J, Gallego-Fabrega C, González-Sánchez J, Del Mar Freijo M, Álvarez-Sabín J, Molina C, Ribó M, Jimenez-Conde J, Roquer J, Sobrino T, Campos F, Castillo J, Muñoz-Narbona L, Lopez-Cancio E, Dàvalos A, Diaz-Navarro R, Tur S, Vives-Bauza C, Serrano-Heras G, Segura T, Krupinski J, Delgado-Mederos R, Martí-Fàbregas J, Heitsch L, Ibañez L, Cruchaga C, Rost NS, Montaner J, Lee JM, Fernandez-Cadenas I
Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke.
Stroke.
de Albóniga-Chindurza A, Ortega-Quintanilla J, Alcalde-López J, Zapata-Arriaza E, González A
Intra-arterial gadolinium as an alternative to iodinated contrast agent in thrombectomy.
Neurologia
Macías-García D, Jurado Serrano J, Parada Blazquez MJ, Moniche F
Acute lower limb paresis in a patient with rheumatoid arthritis: Emergency neuroimaging findings.
Neurologia.

Actualidad

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CONVOCATORIA RETOS-COLABORACIÓN DEL AÑO 2017, CORRESPONDIENTES AL PROGRAMA ESTATAL DE INVESTIGACIÓN, DESARROLLO E INNOVACIÓN ORIENTADA A LOS RETOS EN LA SOCIEDAD, EN EL MARCO DEL PLAN ESTATAL DE INVESTIGACIÓN CIENTÍFICA Y TÉCNICA Y DE INNOVACIÓN 2013-2016.

RETOS COLAB 2017 MONTANER VILLALONGA, JOAN. RTC-2017-6651-1 PROYECTO NEUROTOLL - DESARROLLO Y VALIDACIÓN CLÍNICA DE UN APTÁMERO TERAPÉUTICO PARA EL TRATAMIENTO DEL ICTUS ISQUÉMICO AGUDO. Concedido 307,496.16€

ApTOLL es un aptámero de cadena sencilla de DNA que supone una estrategia novedosa para el tratamiento de múltiples patologías en las que se produzcan procesos inflamatorios agudos. El objetivo principal del proyecto persigue llevar a cabo una prueba de concepto preliminar en un grupo de pacientes de ictus. Se diseñará un estudio que incluya varios grupos de estudio, de acuerdo con las características farmacocinéticas de la molécula y los resultados obtenidos en los estudios preclínicos, así como a decisiones estratégicas de posicionamiento en la ventana terapéutica de la fase aguda y en cuanto a la co-administración de otras terapias coadyuvantes, de acuerdo con el criterio de los investigadores participantes y la opinión de un pool de expertos en el campo del ictus y de la industria farmacéutica, con el fin de evaluar nichos de posicionamiento de producto y maximizar la eficacia del mismo. Para ello se ha constituido un consorcio colaborativo formado por varios centros de investigación representantes de toda la cadena de valor del proyecto y con experiencia probada en el estudio de nuevas terapias en el tratamiento del ictus, entre ellos el equipo del Dr. Joan Montaner, jefe de Servicio de Neurología del HUVM y director del Programa Ictus IBIS-HUVM-HUVR.

 

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RETOS-COLABORACIÓN 2016 - JOAN MONTANER VILLALONGA- RTC-2016-5300-1, financiado por MINISTERIO DE ECONOMÍA, INDUSTRIA Y COMPETITIVIDAD. Concedido 254.944,20 €

Título: "ALImentos Neuroprotectores Enriquecidos en Omega-3 (ALINEO-3)"

La hipótesis de trabajo del proyecto ALINEO-3 propone que el consumo habitual de productos funcionales a los que estamos habituados (quesos, carnes, etc) y por tanto de "fácil" consumo y suplementados con ácidos omega-3 podría tener efectos beneficiosos cuando se produzca un infarto cerebral, reduciendo la lesión isquémica y el déficit neurológico. Es por ello que se plantea el estudio del efecto neuroprotector del pretratamiento con una dieta suplementada con ácidos omega-3 en un modelo de isquemia focal transitoria por oclusión distal de la arteria cerebral media en ratón (preclínica) y trasladar la mejor combinación de dieta neuroprotectora a sujetos con alto riesgo de sufrir ictus cerebral.