Cellular Neurobiology and Biophysics

José López Barneo
José López Barneo
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla

Laboratory: 101

José López Barneo

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  1. Group members
  2. Research areas
  3. Publications

Group: Cellular Neurobiology and Biophysics

Group members Cellular Neurobiology and Biophysics
  • Acosta Silva, María Jesús.Grado en Biología
  • Cabeza Fernández, José María.Doctor en Biología. Técnico especialista
  • Colinas Miranda, Olalla.Dra. en Fisiología Médica. Técnico especialista.
  • d'Anglemont de Tassigny, Xavier.PhD in Biology. Post-doctoral fellow.
  • Gao, Lin.PhD in Biology. Researcher (I3SNS).
  • García Flores, Paula.Degree in Biology. Technician.
  • González Rodríguez, Patricia.Doctora en Biología
  • Jiménez Gómez, Blanca.Beca FPI
  • López Barneo, José.MD/PhD. Professor/Head of Service (Univ. Seville/HUVR)
  • Moreno Domínguez, Alejandro.Doctor en Biología
  • Muñoz Cabello, Ana María .Doctorado en Biología.
  • Ortega Sáenz, Gracia Patricia.Doctorado en Farmacia.
  • Torres López, María.Investigadora Predoctoral

Research areas

The scientific work undertaken by our group is related to three fundamental areas:

  • Cellular mechanisms of oxygen sensing.

    Within this area we investigate the nature of the sensors that mediate acute responses to hypoxia, especially in the carotid body and the adrenal medulla. We also investigate the regulation of genes (particularly those that code for ion channels) for chronic hypoxemia (maintained or intermittent). Within the general subject of oxygen homeostasis, we collaborate with other IBIS groups with a view to determining the possible role of aquaporins as oxygen channels. This area of research is related to pathologies derived from cerebral ischaemia or to those that appear in patients with chronic obstructive pulmonary disease or other respiratory alterations.
  • Neurodegeneration and neuroprotection in Parkinson's disease.

    We study the mechanisms of cell death in models of Parkinson's disease by means of the generation of genetically modified animals (transgenic and "knock out" animals). In parallel, the way in which the intrastriatal transplants of cells producing dopamine and neurotrophic factors (for example, cells of the carotid body) slow down the progression of Parkinson's disease is investigated. Within this field, the expansion of the adult carotid body from stem cells described in this organ, and the relation between the growth of cells of the carotid body and its tumour-like transformation, are the subject of on-going research. The clinical objective of this research area is to identify new therapeutic targets for Parkinson's disease and to improve cell therapy techniques applicable to this disease. In collaboration with other IBIS groups in this area, we also aim to better understand the mechanism underlying the genesis of paragangliomas.
  • Pathophysiological mechanisms of hypertension and vascular spasm.

    In collaboration with other IBIS groups we are investigating the role of calcium channels as metabotropic mediators in vascular contractility. Within this area, we also study the regulation of the expression of ion channels by oxygen, especially the T-type calcium channel and the beta1 subunit of the maxi-K channel. The association between intermittent hypoxia, the expression of ion channels in vascular smooth muscle, and vascular risk in patients with sleep apnoea also forms part of our research endeavours.
International Journals
Harasztosi, C; Wolter, S; Gutsche, K; Duran-Alonso, MB; Lopez-Hernandez, I; Pascual, A; Lopez-Barneo, J; Knipper, M; Ruttiger, L; Schimmang, T
Differential deletion of GDNF in the auditory system leads to altered sound responsiveness
Enterria-Morales, D; Lopez-Lopez, I; Lopez-Barneo, J; de Tassigny, XD
Role of Glial Cell Line-Derived Neurotrophic Factor in the Maintenance of Adult Mesencephalic Catecholaminergic Neurons
Sanchez-Lopez, V; Gao, L; Ferrer-Galvan, M; Arellano-Orden, E; Elias-Hernandez, T; Jara-Palomares, L; Asensio-Cruz, MI; Castro-Perez, MJ; Rodriguez-Martorell, FJ; Lobo-Beristain, JL; Ballaz-Quincoces, A; Lopez-Campos, JL; Vila-Liante, V; Otero-Candelera, R
Differential biomarker profiles between unprovoked venous thromboembolism and cancer
Al Khazal, F; Kang, S; Holte, MN; Choi, DS; Singh, R; Ortega-Saenz, P; Lopez-Barneo, J; Maher, LJ
Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency
Moreno-Dominguez, A; Ortega-Saenz, P; Gao, L; Colinas, O; Garcia-Flores, P; Bonilla-Henao, V; Aragones, J; Huttemann, M; Grossman, LI; Weissmann, N; Sommer, N; Lopez-Barneo, J
Acute O-2 sensing through HIF2 alpha-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors
Ortega-Saenz, P; Lopez-Barneo, J
Physiology of the Carotid Body: From Molecules to Disease
Ortega-Saenz, P; Moreno-Dominguez, A; Gao, L; Lopez-Barneo, J
Molecular Mechanisms of Acute Oxygen Sensing by Arterial Chemoreceptor Cells. Role of Hif2 alpha
Sobrino, V; Platero-Luengo, A; Annese, V; Navarro-Guerrero, E; Gonzalez-Rodriguez, P; Lopez-Barneo, J; Pardal, R
Neurotransmitter Modulation of Carotid Body Germinal Niche
Enterria-Morales, D; Del Rey, NLG; Blesa, J; Lopez-Lopez, I; Gallet, S; Prevot, V; Lopez-Barneo, J; de Tassigny, XD
Molecular targets for endogenous glial cell line-derived neurotrophic factor modulation in striatal parvalbumin interneurons
Harasztosi C, Wolter S, Gutsche K, Durán-Alonso MB, López-Hernández I, Pascual A, López-Barneo J, Knipper M, Rüttiger L, Schimmang T
Differential deletion of GDNF in the auditory system leads to altered sound responsiveness.
J Neurosci Res.
Cabello-Rivera D, Sarmiento-Soto H, López-Barneo J, Muñoz-Cabello AM
Mitochondrial Complex I Function Is Essential for Neural Stem/Progenitor Cells Proliferation and Differentiation.
Front Neurosci.
Gao L, Ortega-Sáenz P, López-Barneo J
Acute oxygen sensing-Role of metabolic specifications in peripheral chemoreceptor cells.
Respir Physiol Neurobiol.
Arias-Mayenco I, González-Rodríguez P, Torres-Torrelo H, Gao L, Fernández-Agüera MC, Bonilla-Henao V, Ortega-Sáenz P, López-Barneo J.
Acute O2 Sensing: Role of Coenzyme QH2/Q Ratio and Mitochondrial ROS Compartmentalization
Cell Metab.
Dong C, Helton ES, Zhou P, Ouyang X, d'Anglemont de Tassigny X, Pascual A, López-Barneo J, Ubogu EE. .
Glial-derived neurotrophic factor is essential for blood-nerve barrier functional recovery in an experimental murine model of traumatic peripheral neuropathy.
Tissue Barriers
Gao L, Ortega-Sáenz P, López-Barneo J.
Acute oxygen sensing-Role of metabolic specifications in peripheral chemoreceptor cells.
Respir Physiol Neurobiol.
López-Barneo J.
All for one - O2 -sensitive K+ channels that mediate carotid body activation
J Physiol
López-Barneo J.
Oxygen sensing and stem cell activation in the hypoxic carotid body.
Cell Tissue Res.
Macías D, Cowburn AS, Torres-Torrelo H, Ortega-Sáenz P, López-Barneo J,
HIF-2α is essential for carotid body development and function.
Johnson RS Elife
Sobrino V, González-Rodríguez P, Annese V, López-Barneo J, Pardal R.
Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia.
Torres-Torrelo H, Ortega-Sáenz P, Macías D, Omura M, Zhou T, Matsunami H, Johnson RS, Mombaerts P, López-Barneo J.
The role of Olfr78 in the breathing circuit of mice.
. Barrientos-Moreno M, Murillo-Pineda M, Muñoz-Cabello AM, Prado F.
Histone depletion prevents telomere fusions in pre-senescent cells
PLoS Genet