Research areas
Our group studies the biology of progenitor/stem cells in the adult nervous system. These cells reside in specific niches, from where they participate in the development, maintenance and repair of the neural tissue. The cellular and molecular contacts established within the niche, between the stem cells and the rest of the niche components, are essential for the normal functioning of neural stem cells. A disruption of these niche crosstalks could lead to disease conditions, due to a lack of regenerative capacity or to hyperproliferation within the niche. Our detailed studies on these neurogenic niches might contribute to an understanding of the mechanisms underlying tumorigenic growth within the nervous system.
Vega, FM; Colmenero-Repiso, A; Gomez-Munoz, MA; Rodriguez-Prieto, I; Aguilar-Morante, D; Ramirez, G; Marquez, C; Cabello, R; Pardal, R
Response to "High CD44 expression is not a prognosis marker in patients with high-risk neuroblastoma"
EBIOMEDICINE
Burgoyne, AM; Vann, KR; Joshi, S; Morales, GA; Vega, FM; Singh, A; Pal, D; Merati, AB; Kutateladze, TG; Durden, DL
A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity
CELL DISCOVERY
Colmenero-Repiso, A; Gomez-Munoz, MA; Rodriguez-Prieto, I; Amador-Alvarez, A; Henrich, KO; Pascual-Vaca, D; Okonechnikov, K; Rivas, E; Westermann, F; Pardal, R; Vega, FM
Identification of VRK1 as a New Neuroblastoma Tumor Progression Marker Regulating Cell Proliferation
CANCERS
Huertas-Castano, C; Gomez-Munoz, MA; Pardal, R; Vega, FM
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Sobrino, V; Platero-Luengo, A; Annese, V; Navarro-Guerrero, E; Gonzalez-Rodriguez, P; Lopez-Barneo, J; Pardal, R
Neurotransmitter Modulation of Carotid Body Germinal Niche
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Nieto-González JL, Gómez-Sánchez L, Mavillard F, Linares-Clemente P, Rivero MC, Valenzuela-Villatoro M, Muñoz-Bravo JL, Pardal R, Fernández-Chacón R
Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α.
Proc Natl Acad Sci U S A
Sobrino V, Annese V, Navarro-Guerrero E, Platero-Luengo A, Pardal R
The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system.
Cell Mol Life Sci.
Vega FM, Colmenero-Repiso A, Gómez-Muñoz MA, Rodríguez-Prieto I, Aguilar-Morante D, Ramírez G, Márquez C, Cabello R, Pardal R
CD44-high neural crest stem-like cells are associated with tumour aggressiveness and poor survival in neuroblastoma tumours.
EBioMedicine.
Huertas-Castaño C, Gómez-Muñoz MA, Pardal R, Vega FM
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours.
Int J Mol Sci.
Sobrino V, Annese V, Pardal R
Progenitor Cell Heterogeneity in the Adult Carotid Body Germinal Niche.
Adv Exp Med Biol.
Sobrino V, González-Rodríguez P, Annese V, López-Barneo J, Pardal R.
Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia.
EMBO Rep.
Vega FM, Ridley AJ.
The RhoB small GTPase in physiology and disease
Small GTPases.
