Research areas
Our group studies the biology of progenitor/stem cells in the
adult nervous system. These cells reside in specific niches, from
where they participate in the development, maintenance and repair
of the neural tissue. The cellular and molecular contacts
established within the niche, between the stem cells and the rest
of the niche components, are essential for the normal functioning
of neural stem cells. A disruption of these niche crosstalks could
lead to disease conditions, due to a lack of regenerative capacity
or to hyperproliferation within the niche. Our detailed studies on
these neurogenic niches might contribute to an understanding of the
mechanisms underlying tumorigenic growth within the nervous
system.
Vega, FM; Colmenero-Repiso, A; Gomez-Munoz, MA; Rodriguez-Prieto, I; Aguilar-Morante, D; Ramirez, G; Marquez, C; Cabello, R; Pardal, R
Response to "High CD44 expression is not a prognosis marker in patients with high-risk neuroblastoma"
EBIOMEDICINE
Burgoyne, AM; Vann, KR; Joshi, S; Morales, GA; Vega, FM; Singh, A; Pal, D; Merati, AB; Kutateladze, TG; Durden, DL
A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity
CELL DISCOVERY
Colmenero-Repiso, A; Gomez-Munoz, MA; Rodriguez-Prieto, I; Amador-Alvarez, A; Henrich, KO; Pascual-Vaca, D; Okonechnikov, K; Rivas, E; Westermann, F; Pardal, R; Vega, FM
Identification of VRK1 as a New Neuroblastoma Tumor Progression Marker Regulating Cell Proliferation
CANCERS
Huertas-Castano, C; Gomez-Munoz, MA; Pardal, R; Vega, FM
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Sobrino, V; Platero-Luengo, A; Annese, V; Navarro-Guerrero, E; Gonzalez-Rodriguez, P; Lopez-Barneo, J; Pardal, R
Neurotransmitter Modulation of Carotid Body Germinal Niche
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Nieto-González JL, Gómez-Sánchez L, Mavillard F, Linares-Clemente P, Rivero MC, Valenzuela-Villatoro M, Muñoz-Bravo JL, Pardal R, Fernández-Chacón R
Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α.
Proc Natl Acad Sci U S A
Sobrino V, Annese V, Navarro-Guerrero E, Platero-Luengo A, Pardal R
The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system.
Cell Mol Life Sci.
Vega FM, Colmenero-Repiso A, Gómez-Muñoz MA, Rodríguez-Prieto I, Aguilar-Morante D, Ramírez G, Márquez C, Cabello R, Pardal R
CD44-high neural crest stem-like cells are associated with tumour aggressiveness and poor survival in neuroblastoma tumours.
EBioMedicine.
Huertas-Castaño C, Gómez-Muñoz MA, Pardal R, Vega FM
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours.
Int J Mol Sci.
Sobrino V, Annese V, Pardal R
Progenitor Cell Heterogeneity in the Adult Carotid Body Germinal Niche.
Adv Exp Med Biol.
Sobrino V, González-Rodríguez P, Annese V, López-Barneo J, Pardal R.
Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia.
EMBO Rep.
Vega FM, Ridley AJ.
The RhoB small GTPase in physiology and disease
Small GTPases.
Annese V, Navarro-Guerrero E, Rodríguez-Prieto I, Pardal R.
Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body.
Cell Rep.
Erdreich-Epstein A, Singh AR, Joshi S, Vega FM, Guo P, Xu J, Groshen S, Ye W, Millard M, Campan M, Morales G, Garlich JR, Laird PW, Seeger RC, Shimada H, Durden DL.
Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126
Oncotarget.
García-Pras E, Gallego J, Coch L, Mejías M, Fernández-Miranda G, Pardal R, Bosch J, Méndez R, Fernández M.
Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension.
Gut.
Linares-Clemente P, Aguilar-Morante D, Rodríguez-Prieto I, Ramírez G, de Torres C, Santamaría V, Pascual-Vaca D, Colmenero-Repiso A, Vega FM, Mora J, Cabello R, Márquez C, Rivas E, Pardal R.
Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in stage 4/M neuroblastoma.
Oncotarget
Vega FM, Gautier V, Fernández-Ponce CM, Extremera MJ, Altelaar AFM, Millán J, Téllez JC, Hernández-Campos JA, Conejero R, Bolivar J, Pardal R, García-Cózar FJ, Aguado E, Heck AJR, Durán-Ruiz MC.
The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo.
J Mol Cell Cardiol
