Neurosciences

Synaptic dysfunction in brain disorders

F. Manuel Gómez
F. Manuel Gómez
IBiS
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla
Laboratory: 107
María A. Martínez
María A. Martínez
IBiS
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla

Laboratory: 107

María A.  Martínez

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  1. Group members
  2. Research areas
  3. Publications

Group: Synaptic dysfunction in brain disorders

Directory
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  • Carrasco Poley, Sonia .Graduada en Psicología
  • Gómez , F. Manuel.PhD of Science. Associate Professor (University of Seville).
  • Martínez, María A. .PhD in Biology. Staff Scientist (CSIC).
  • Sánchez Gómez, Angela.

Research areas

  • Our research is focused on the study of prevalent brain disorders, such as Alzheimer's disease, autism and other neurological disorders, combining Neurobiology and Human Genetics approaches. To this aim, we study the molecular mechanisms that mediate synapse formation in normal conditions and in brain disorders. Our specific aims are:

    • The study of the synaptic pathway mediated by adhesion molecules such as neurexins and neuroligins in normal conditions and how this is affected in brain disorders.
    • The phenotypic and molecular characterization of animal models that reproduce genetic alterations identified in patients.
    • The identification of genetic variants associated with brain disorders, mainly Alzheimer's disease and autism.

    To reach these goals, we follow a combined approach that includes behavioral assays in mouse models, cellular and molecular neurobiology approaches and the study of synapse function using imaging techniques, among others.

International Journals
Ana C. Sánchez-Hidalgo, Francisco Arias-Aragón, Teresa Romero-Barragán, Celia Martín-Cuevas, José M. Delgado-García, Amalia Martinez-Mir, Francisco G. Scholl
Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity
Experimental Neurology
Maria I. Alvarez-Vergara, Alicia E. Rosales-Nieves, Rosana March-Diaz, Guiomar Rodriguez-Perinan, Nieves Lara-Ureña, Clara Ortega-de San Luis, Manuel A. Sanchez-Garcia, Miguel Martin-Bornez, Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Beatriz Fernandez-Gomez, Miguel A. Marchena, Andrea S. Bullones-Bolanos, Jose C. Davila, Rocio Gonzalez-Martinez, Jose L. Trillo-Contreras, Ana C. Sanchez-Hidalgo, Raquel del Toro, Francisco G. Scholl, Eloisa Herrera, Martin Trepel, Jakob Körbelin, Luis M. Escudero, Javier Villadiego, Miriam Echevarria, Fernando de Castro, Antonia Gutierrez, Alberto Rabano, Javier Vitorica & Alberto Pascual
Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
Nat Commun 12
PubMed
Carbonell-Corvillo P, Tristán-Clavijo E, Cabrera-Serrano M, Servián-Morilla E, García-Martín G, Villarreal-Pérez L, Rivas-Infante E, Area-Gómez E, Chamorro-Muñoz MI, Gil-Gálvez A, Miranda-Vizuete A, Martinez-Mir A, Laing N, Paradas C.
A novel MYH7 founder mutation causing Laing distal myopathy in Southern Spain.
Neuromuscul Disord.
PubMed
Servián-Morilla E, Robles-Lanuza E, Sánchez-Hidalgo AC, Camacho-Garcia RJ, Paez-Gomez JA, Mavillard F, Saura CA, Martinez-Mir A, Scholl FG.
Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release (1)
J Neurosci.
PubMed
Servián-Morilla E, Robles-Lanuza E, Sánchez-Hidalgo AC, Camacho-García RJ, Páez-Gómez JA, Mavillard F, Saura CA, Martínez-Mir A, Scholl FG.
Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release
J Neurosci