Enfermedades infecciosas y del sistema inmunitario

Alteraciones congénitas de inmunidad

Olaf Neth
Olaf Neth

Olaf Neth

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  1. Miembros del grupo
  2. Áreas de trabajo
  3. Publicaciones

Grupo: Alteraciones congénitas de inmunidad

Directorio
Foto no disponible
  • Aboza García, Marta.FEA HUVR
  • Agudo Montore , Pedro.Ldo. en Medicina y Cirugía
  • Blanco Lobo, Pilar.Investigadora Postdoctoral. Doctora en Biología Molecular
  • Camacho Lovillo, M Soledad .FEA HUVR Doctora en Medicina y Cirugía
  • de Felipe Carrillo, Beatriz.Técnico de Apoyo. Doctora en Biología
  • Falcón Neyra, Mª Dolores.FEA HUVR
  • Goycochea Valdivia, Walter Alfredo.FEA HUVR
  • Guisado Hernández, Paloma.
  • Marín Cruz, Inés.Lda. en Medicina y Cirugía
  • Neth, Olaf.Jefe de Sección de Enfermedades Infecciosas, Reumatologia e Inmuno-deficienicas, Hospital Infantil. Hospital Universitario Virgen del Rocío
  • Obando Santaella, Ignacio.FEA HUVR Doctor en Medicina y Cirugía
  • Olbrich, Peter.Investigador Postdoctoral Juan Rodés. Doctor en Medicina y Cirugía
  • Pérez Borrego , Esther.Lda. Medicina y Cirugía
  • Queralt García de Góngora, Macarena.Lda. en Medicina y Cirugía
  • Salazar Quero, José Carlos.Doctor en Medicina y Cirugía
  • Sánchez Moreno, Paula.Doctora en Medicina y Cirugía
  • Sánchez Romero, Miguel Ángel .Ldo. en Medicina y Cirugía

Áreas de trabajo

El grupo de Alteraciones Congénitas de Inmunidad (Inborn Error of Immunity, IEI), liderado por el Dr. Olaf Neth, forma parte de la Unidad de Pediatría de Enfermedades Infecciosas, Reumatología e Inmunología del Hospital Universitario Virgen del Rocío de Sevilla (HUVR), referente local, regional, nacional e internacional, dirigido a la asistencia, investigación y educación. Asimismo, el grupo IEI se engloba en el área de Enfermedades Infecciosas y del Sistema Inmunitario del Instituto de Biomedicina de Sevilla (IBiS). 

Las principales líneas de investigación en activo del grupo IEI son:

1. Cribado neonatal para la detección precoz de inmunodeficiencias primarias (IDPs)

- Cuantificación de T-cell receptor excision circles (TREC) y K-deleting recombination excision circles (KREC) mediante la prueba del talón de recién nacidos.

 - Ampliación de SMN1 para el diagnóstico precoz de atrofia muscular espinal (AME) con la misma prueba de talón 

2. Optimización del diagnóstico y manejo de pacientes con alteraciones inmunitarias.

- Evaluación del impacto terapéutico especifico del uso de los inhibidores de la JAK1/2 en pacientes (in vitro) y en modelo murino (in vivo) con STAT3 LOF y STAT1 GOF, así como estudiar la susceptibilidad a infecciones pulmonares por S aureus y S pneumoniae en ratones transgénicos mut-STAT3 LOF y mut-STAT1 GOF

- Cribado de la deficiencia de ADA2 en niños y adultos, una enfermedad autoinflamatoria infradiagnosticada con amplio espectro clínico y co-morbidad.

3. Aproximaciones proteómicas para el desarrollo de vacunas anti-neumocócicas y métodos diagnósticos novedosos.

- Vigilancia epidemiológica “reforzada” de enfermedad invasiva neumocócica en pacientes pediátricos.

- Caracterización de la epidemiología y los serotipos / genotipos de S. pneumoniae en portadores nasofaríngeos.

- Identificación de potenciales candidatos vacunales proteicos prometedores en base a su abundancia, conservación y capacidad inmunogénica

 

Revistas Internacionales
López Marcos M, Ruiz Sáez B, Vílchez Pérez JS, Moreno Pérez D, Carazo Gallego B, Falcón Neyra L, Goycochea Valdivia WA, Obando Santaella I, Lucena Soto JM, Díaz Martos J, Santos Pérez JL, Rodríguez Benjumea M, Angulo González de Lara R, Sánchez Codez MI, Peromingo Matute E, Cruz Cañete M, Calviño Molinero J, Hurtado Mingo Á, Lendínez Molinos F, Medina Claros AF, Muñoz Vilches MJ, Neth O*, Olbrich P; GAIIP (Grupo Andaluz de Infectología e Inmunopatología Pediátrica) Network.
Distinct Laboratory and Clinical Features of Secondary Hemophagocytic Lymphohistiocytosis in Pediatric Visceral Leishmaniasis: A Retrospective Analysis of 127 Children in Andalusia, Spain (2004-2019).
Pediatr Infect Dis J.
Méndez-Echevarría A, Sainz T, de Felipe B, Alcolea S, Olbrich P, Goycochea-Valdivia WA, Escosa-García L, Cobo L, Calvo C, Neth O.
High Rates of SARS-CoV-2 Family Transmission in Children of Healthcare Workers During the First Pandemic Wave in Madrid, Spain: Serologic Study.
Pediatr Infect Dis J.
Villaverde S, Domínguez-Rodríguez S, Sabrido G, Pérez-Jorge C, Plata M, Romero MP, Grasa CD, Jiménez AB, Heras E, Broncano A, Núñez MDM, Illán M, Merino P, Soto B, Molina-Arana D, Bermejo A, Mendoza P, Gijón M, Pérez-Moneo B, Moraleda C, Tagarro A; Epidemiological Study of COVID-19 in Children of the Spanish Society of Pediatric (EPICO-AEP) Working Group.
Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population.
J Pediatr.
Fernández-Cooke E, Grasa CD, Domínguez-Rodríguez S, Barrios Tascón A, Sánchez-Manubens J, Anton J, Mercader B, Villalobos E, Camacho M, Navarro Gómez ML, Oltra Benavent M, Giralt G, Bustillo M, Bello Naranjo AM, Rocandio B, Rodríguez-González M, Núñez Cuadros E, Aracil Santos J, Moreno D, Calvo C; KAWA-RACE Study Group.
Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain.
Front Pediatr.
Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, Rosen LB, Lwin W, Renteria A, Pontejo SM, Shannon JP, Myles IA, Olbrich P, Ferré EMN, Schmitt M, Martin D; Genomics and Computational Biology Core, Barber DL, Solis NV, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Anderson MS, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis MS.
Aberrant type 1 immunity drives susceptibility to mucosal fungal infections.
Science
European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) Study Group in EuroCoord.
Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study.
Clin Infect Dis.
Martín-Gutiérrez G, et al. PRIOAM team.
Efficacy and Safety of a Comprehensive Educational Antimicrobial Stewardship Program Focused on Antifungal Use.
J Infect.
Calvo C, et al.; Grupo de trabajo de la Asociación Española de Pediatría para el brote de infección por Coronavirus, colaboradores con el Ministerio de Sanidad; Miembros del Grupo de Expertos de la AEP.
Recommendations on the clinical management of the COVID-19 infection by the «new coronavirus» SARS-CoV2. Spanish Paediatric Association working group.
An Pediatr (Barc).
Basu Roy R, et al. ptbnet TB Meningitis Study Group.
Performance of immune-based and microbiological tests in children with TB meningitis in Europe - a multi-center Paediatric Tuberculosis Network European Trials Group (ptbnet) study.
Eur Respir J.
Gijón M, et al.
PEDIATRIC COMMUNITY-ACQUIRED BONE AND JOINT STAPHYLOCOCCUS AUREUS INFECTIONS IN EUROPE: SEVERE INFECTIONS ARE ASSOCIATED TO PANTON-VALENTINE LEUCOCIDIN PRESENCE.
Pediatr Infect Dis J.
Götzinger F, et al.
COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study
Lancet Child Adolesc Health.
Quintana-Ortega C, et al.
Colchicine treatment in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: A multicenter study in Spain.
Eur J Rheumatol.
Cordero E, et al.
Executive Summary of the Consensus Document on the Diagnosis and Management of Patients with Primary Immunodeficiencies.
J Allergy Clin Immunol Pract.
Cordero E, et al.
Executive Summary of the Consensus Document on the Diagnosis and Management of Patients with Primary Immunodeficiencies.
Enferm Infecc Microbiol Clin.
Pezzani MD, et al. COACH working group.
Linking antimicrobial resistance surveillance to antibiotic policy in healthcare settings: the COMBACTE-Magnet EPI-Net COACH project.
J Antimicrob Chemother.
Noguera-Julian A et al.
Tuberculosis Disease in Children and Adolescents on Therapy With Antitumor Necrosis Factor-ɑ Agents: A Collaborative, Multicenter Paediatric Tuberculosis Network European Trials Group (ptbnet) Study.
Clin Infect Dis.
López-Medina EM et al.
Tuberculosis in a Spanish cohort of children living with HIV: the CHOTIS study (Childhood HIV & TB study).
Int J Tuberc Lung Dis.
Carrasco I et al.
Response to direct-acting antivirals for hepatitis C treatment in vertically HIV/HCV co-infected patients.
Viral Hepat.
Sainz T et al.
Longitudinal evolution of vertically HIV/HCV-co-infected vs HCV-mono-infected children. Pediatric National AIDS Research Network of Spain (CORISPE) integrated in the Translational Research Network in Pediatric Infectious Diseases (RITIP).
J Viral Hepat.
Fernández-McPhee C et al
Effect of Hepatitis C Virus Coinfection on the Progression of Vertically Acquired Human Immunodeficiency Virus Infection During Childhood and Adolescence. .
.J Pediatric Infect Dis Soc.
Yazdani R, et al.
Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management.
J Investig Allergol Clin Immunol
Jamee M, et al.
Clinical, Immunological, and Genetic Features in Patients with Activated PI3Kδ Syndrome (APDS): a Systematic Review.
Clin Rev Allergy Immunol.
Fekrvand S, et al.
Primary Immunodeficiency Diseases and Bacillus Calmette-Guérin (BCG)-Vaccine-Derived Complications: A Systematic Review.
J Allergy Clin Immunol Pract.
Fekrvand S, et al.
Evaluation of respiratory complications in patients with X-linked and autosomal recessive agammaglobulinemia.
Pediatr Allergy Immunol.
Moazzami B, et al.
Comprehensive assessment of respiratory complications in patients with common variable immunodeficiency.
Ann Allergy Asthma Immunol.
García-Laorden MI, Hernández-Brito E, Muñoz-Almagro C, Pavlovic-Nesic S, Rúa-Figueroa I, Briones ML, Rajas O, Borderías L, Payeras A, Lorente L, Freixinet J, Ferreres J, Obando I, González-Quevedo N, Rodríguez de Castro F, Solé-Violán J, Rodríguez-Gallego C.
Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway.
J Clin Immunol.
Luis Martinez-Sobrido, Pilar Blanco-Lobo , Laura Rodriguez , Theresa Fitzgerald , Hanyuan Zhang, Ph;. 2020.
Characterizing Emerging Canine H3 Influenza Viruses.
Plos Pathogens.
Jun-Gyu Park, Ginés Ávila-Pérez , Aitor Nogales, Pilar Blanco-Lobo, Juan C de la Torre, L. 2020.
Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses.
J Virol.
Vives-Oñós I, Codina-Grau MG, Noguera-Julian A, Blázquez-Gamero D, Fortuny C, Baquero-Artigao F, Frick MA, Saavedra-Lozano J, Goycochea-Valdivia W, Rives-Ferreiro MT, Montesdeoca-Melián A, Calavia-Garsaball O, Ferreras-Antolin L, Marín-Soria JL, Dulín-Íñiguez E, Soler-Palacín P; REDICCMV Study Group
Is Polymerase Chain Reaction in Neonatal Dried Blood Spots Reliable for the Diagnosis of Congenital Cytomegalovirus Infection?
Pediatr Infect Dis J.
Sánchez-Ramón S, Bermúdez A, González-Granado LI, Rodríguez-Gallego C, Sastre A, Soler-Palacín P; ID-Signal Onco-Haematology Group.
Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management.
Front Immunol.
Jamee M, Moniri S, Zaki-Dizaji M, Olbrich P, Yazdani R, Jadidi-Niaragh F, Aghamahdi F, Abolhassani H, Condliffe AM, Aghamohammadi A, Azizi G.
Clinical, Immunological, and Genetic Features in Patients with Activated PI3Kδ Syndrome (APDS): a Systematic Review.
Clin Rev Allergy Immunol.
Yazdani R, Habibi S, Sharifi L, Azizi G, Abolhassani H, Olbrich P, Aghamohammadi A.
Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical manifestations, Diagnosis, Classification and Management.
J Investig Allergol Clin Immunol.
Goycochea-Valdivia WA, Montecatine-Alonso E, Gil-Navarro MV, Neth O.
In reply to: "Antimicrobial defined daily dose adjusted by weight: A proposal for antibiotic consumption measurement in children".
J Investig Enferm Infecc Microbiol Clin.
Borghini L, Png E, Binder A, Wright VJ, Pinnock E, de Groot R, Hazelzet J, Emonts M, Van der Flier M, Schlapbach LJ, Anderson S, Secka F, Salas A, Fink C, Carrol ED, Pollard AJ, Coin LJ, Kuijpers TW, Martinon-Torres F, Zenz W, Levin M, Hibberd ML, Davila S; EUCLIDS consortium.
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.
Sci Rep.
Jägle S, Heeg M, Grün S, Rensing-Ehl A, Maccari ME, Klemann C, Jones N, Lehmberg K, Bettoni C, Warnatz K, Grimbacher B, Biebl A, Schauer U, Hague R, Neth O, Mauracher A, Pachlopnik Schmid J, Fabre A, Kostyuchenko L, Führer M, Lorenz MR, Schwarz K, Rohr J, Ehl S.
Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity.
Clin Immunol.
Wang X, Nijman R, Camuzeaux S, Sands C, Jackson H, Kaforou M, Emonts M, Herberg JA, Maconochie I, Carrol ED, Paulus SC, Zenz W, Van der Flier M, de Groot R, Martinon-Torres F, Schlapbach LJ, Pollard AJ, Fink C, Kuijpers TT, Anderson S, Lewis MR, Levin M, McClure M; EUCLIDS consortium.
Plasma lipid profiles discriminate bacterial from viral infection in febrile children.
Sci Rep
Hong Y, Nanthapisal S, Omoyinmi E, Olbrich P, Neth O, Speckmann C, Lucena JM, Gilmour K, Worth A; Genomics England Research Consortium, Klein N, Eleftheriou D, Brogan P.
Secondary C1q Deficiency in Activated PI3Kδ Syndrome Type 2.
Front Immunol.
Passerini L, Barzaghi F, Curto R, Sartirana C, Barera G, Tucci F, Albarello L, Mariani A, AlbertoTestoni P, Bazzigaluppi E, Bosi E, Lampasona V, Neth O, Zama D, Hoenig M, Schulz A, Seidel MG, Rabbone I, Olek S, Roncarolo MG, Cicalese MP, Aiuti A, Bacchetta R.
Treatment with Rapamycin Can Restore Regulatory T Cell Function in IPEX Patients.
J Allergy Clin Immunol.
Barzaghi F, Amaya Hernández LC, Neven B, Ricci S, Kucuk ZY, Bleesing JJ, Nademi Z, Slatter MA, Ulloa ER, Shcherbina A, Roppelt A, Worth A, Silva J, Aiuti A, Murguia-Favela L, Speckmann C, Carneiro-Sampaio M, Fernandes JF, Baris S, Ozen A, Karakoc-Aydiner E, Kiykim A, Schulz A, Steinmann S, Notarangelo LD, Gambineri E, Lionetti P, Shearer WT, Forbes LR, Martínez C, Moshous D, Blanche S, Fisher A, Ruemmele FM, Tissandier C, Ouachee-Chardin M, Rieux-Laucat F, Cavazzana M, Qasim W, Lucarelli B, Albert MH, Kobayashi I, Alonso L, Díaz De Heredia C, Kanegane H, Lawitschka A, Seo JJ, González-Vicent M, Díaz MA, Goyal RK, Sauer MG, Yesilipek A, Kim M, Yilmaz-Demirdag Y, Bhatia M, Khlevner J, Richmond Padilla EJ, Martino S, Montin D, Neth O, Molinos-Quintana A, Valverde-Fernández J, Broides A, Pinsk V, Ballauf A, Haerynck F, Bordon V, Dhooge C, García-Lloret ML, Bredius RG, Kałwak K, Haddad E, Seidel MG, Duckers G, Pai SY, Dvorak CC, Ehl S, Locatelli F, Goldman F, Gennery AR, Cowan MJ, Roncarolo MG, Bacchetta R, Primary Immune Deficiency Treatment Consortium (PIDTC) and the Inborn Errors Working Party (IEWP) of the European Society for Blood and Marrow Transplantation (EBMT).
Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study.
J Allergy Clin Immunol.
Cura Daball P, Ventura Ferreira MS, Ammann S, Klemann C, Lorenz MR, Warthorst U, Leahy TR, Conlon N, Roche J, Soler-Palacín P, García-Prat M, Fuchs I, Fuchs S, Beier F, Brümmendorf TH, Speckmann C, Olbrich P, Neth O, Schwarz K, Ehl S, Rensing-Ehl A.
CD57 identifies T cells with functional senescence before terminal differentiation and relative telomere shortening in patients with activated PI3 kinase delta syndrome.
Immunol Cell Biol.
Egg D, Schwab C, Gabrysch A, Arkwright PD, Cheesman E, Giulino-Roth L, Neth O, Snapper S, Okada S, Moutschen M, Delvenne P, Pecher AC, Wolff D, Kim YJ, Seneviratne S, Kim KM, Kang JM, Ojaimi S, McLean C, Warnatz K, Seidl M, Grimbacher B.
Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers.
Front Immunol.
European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) Study Group in EuroCoord.
Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand.
Clin Infect Dis.
Forbes LR, Vogel TP, Cooper MA, Castro-Wagner J, Schussler E, Weinacht KG, Plant AS, Su HC, Allenspach EJ, Slatter M, Abinun M, Lilic D, Cunningham-Rundles C, Eckstein O, Olbrich P, Guillerman RP, Patel NC, Demirdag YY, Zerbe C, Freeman AF, Holland SM, Szabolcs P, Gennery A, Torgerson TR, Milner JD, Leiding JW.
Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations.
J Allergy Clin Immunol.
Hou TZ, Olbrich P, Soto JML, Sánchez B, Moreno PS, Borte S, Stauss HJ, Burns SO, Walker LSK, Pan-Hammarström Q, Hammarström L, Sansom DM, Neth O.
Study of an extended family with CTLA-4 deficiency suggests a CD28/CTLA-4 independent mechanism responsible for differences in disease manifestations and severity.
Clin Immunol.
Maccari ME, Abolhassani H, Aghamohammadi A, Aiuti A, Aleinikova O, Bangs C, Baris S, Barzaghi F, Baxendale H, Buckland M, Burns SO, Cancrini C, Cant A, Cathébras P, Cavazzana M, Chandra A, Conti F, Coulter T, Devlin LA, Edgar JDM, Faust S, Fischer A, García-Prat M, Hammarström L, Heeg M, Jolles S, Karakoc-Aydiner E, Kindle G, Kiykim A, Kumararatne D, Grimbacher B, Longhurst H, Mahlaoui N, Milota T, Moreira F, Moshous D, Mukhina A, Neth O, Neven B, Nieters A, Olbrich P, Ozen A, Pachlopnik Schmid J, Picard C, Prader S, Rae W, Reichenbach J, Rusch S, Savic S, Scarselli A, Scheible R, Sediva A, Sharapova SO, Shcherbina A, Slatter M, Soler-Palacín P, Stanislas A, Suárez F, Tucci F, Uhlmann A, van Montfrans J, Warnatz K, Williams AP, Wood P, Kracker S, Condliffe AM, Ehl S.
Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry.
Front Immunol.
Olbrich P, Freeman AF.
STAT1 and STAT3 mutations: important lessons for clinical immunologists.
Expert Rev Clin Immunol.
Villanueva P, Neth O, Ritz N, Tebruegge M, Paediatric Tuberculosis Network European Trials Group.
Use of Xpert MTB/RIF Ultra assays among paediatric tuberculosis experts in Europe.
Eur Respir J.
Schwab C, Gabrysch A, Olbrich P, Patiño V, Warnatz K, Wolff D, Hoshino A, Kobayashi M, Imai K, Takagi M, Dybedal I, Haddock JA, Sansom DM, Lucena JM, Seidl M, Schmitt-Graeff A, Reiser V, Emmerich F, Frede N, Bulashevska A, Salzer U, Schubert D, Hayakawa S, Okada S, Kanariou M, Kucuk ZY, Chapdelaine H, Petruzelkova L, Sumnik Z, Sediva A, Slatter M, Arkwright PD, Cant A, Lorenz HM, Giese T, Lougaris V, Plebani A, Price C, Sullivan KE, Moutschen M, Litzman J, Freiberger T, van de Veerdonk FL, Recher M, Albert MH, Hauck F, Seneviratne S, Pachlopnik Schmid J, Kolios A, Unglik G, Klemann C, Speckmann C, Ehl S, Leichtner A, Blumberg R, Franke A, Snapper S, Zeissig S, Cunningham-Rundles C, Giulino-Roth L, Elemento O, Dückers G, Niehues T, Fronkova E, Kanderová V, Platt CD, Chou J, Chatila TA, Geha R, McDermott E, Bunn S, Kurzai M, Schulz A, Alsina L, Casals F, Deyà-Martínez A, Hambleton S, Kanegane H, Taskén K, Neth O, Grimbacher B.
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.
J Allergy Clin Immunol
Armangue T, Spatola M, Vlagea A, Mattozzi S, Cárceles-Cordon M, Martinez-Heras E, Llufriu S, Muchart J, Erro ME, Abraira L, Moris G, Monros-Giménez L, Corral-Corral Í, Montejo C, Toledo M, Bataller L, Secondi G, Ariño H, Martínez-Hernández E, Juan M, Marcos MA, Alsina L, Saiz A, Rosenfeld MR, Graus F, Dalmau J.
Spanish Herpes Simplex Encephalitis Study Group. Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis.
Lancet Neurol.
Sánchez-Moreno P, Olbrich P, Falcón-Neyra L, Lucena JM, Aznar J, Neth O
Typhoid fever causing haemophagocytic lymphohistiocytosis in a non-endemic country - first case report and review of the current literature
Enferm Infecc Microbiol Clin.
Grasa CD, Fernandez-Cooke E, Sánchez-Manubens J, Antón J, Crespo D, García M, López A, Lirola Cruz MJ, Díaz-Delgado de la Peña R, Calvo C
Spanish network for the study of Kawasaki disease, KAWA-RACE. Kawasaki disease in infants 3 months of age and younger: a multicentre Spanish study.
Ann Rheum Dis.
Montecatine-Alonso E, Gil-Navarro MV, Fernández-Llamazares CM, Fernández-Polo A, Soler-Palacín P, Llorente-Gutiérrez J, Gómez-Travecedo Calvo MT, Esquivel-Mora MD, Pérez-Rodrigo I, Cisneros JM, Goycochea-Valdivia WA, Neth O.
Paediatric Antimicrobial Defined Daily Dose Study Group (KiDDDs). Antimicrobial defined daily dose adjusted by weight: a proposal for antibiotic consumption measurement in children.
Enferm Infecc Microbiol Clin.
Sánchez-Moreno P, Falcón-Neyra L, Neth O, Delgado Pecellín I.
Hemoptysis and Bronchiolitis Obliterans in Children with Recurrent Respiratory Papillomatosis: Adverse Reactions to Nebulized Cidofovir.
Arch Bronconeumol.
Molina J, Peñalva G, Gil-Navarro MV, Praena J, Lepe JA, Pérez-Moreno MA, Ferrándiz C, Aldabó T, Aguilar M, Olbrich P, Jiménez-Mejías ME, Gascón ML, Amaya-Villar R, Neth O, Rodríguez-Hernández MJ, Gutiérrez-Pizarraya A, Garnacho-Montero J, Montero C, Cano J, Palomino J, Valencia R, Álvarez R, Cordero E, Herrero M, Cisneros JM; PRIOAM team.
Long-term impact of an educational antimicrobial stewardship program on hospital-acquired candidemia and multidrug-resistant bloodstream infections: a quasi-experimental study of interrupted time-series analysis
Clin Infect Dis.
Camacho-Lovillo MS, Bulnes-Ramos A, Goycochea-Valdivia W, Fernández-Silveira L, Núñez-Cuadros E, Neth O*, Pérez-Romero P
Immunogenicity and safety of influenza vaccination in patients with juvenile idiopathic arthritis on biological therapy using the microneutralization assay
Pediatr Rheumatol Online J.
Hou TZ, Verma N, Wanders J, Kennedy A, Soskic B, Janman D, Halliday N, Rowshanravan B, Worth A, Qasim W, Baxendale H, Stauss H, Seneviratne S, Neth O, Olbrich P, Hambleton S, Arkwright PD, Burns SO, Walker LS, Sansom DM.
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations
Blood
Jiménez-Munguía I, van Wamel WJB, Rodríguez-Ortega MJ, Obando I.
Detection of Natural Antibodies and Serological Diagnosis of Pneumococcal Pneumonia Using a Bead-Based High-Throughput Assay.
Methods Mol Biol.
García García E, Falcón-Neyra L, Audí L.
Transient hyperandrogenism in 2 preterm twins with exposure to antiretrovirals.
Med Clin (Barc).
Plácido Paias R, Rodríguez Martínez A, Falcón Neyra MD.
Abdominal pain and asthenia in a 7 years old boy.
Enferm Infecc Microbiol Clin.
Goycochea-Valdivia WA, Moreno-Ramos F, Paño-Pardo JR, Aracil-Santos FJ, Baquero-Artigao F, Del Rosal-Rabes T, Mellado-Peña MJ, Escosa-García L.
Identifying priorities to improve paediatric in-hospital antimicrobial use by cross-sectional evaluation of prevalence and appropriateness of prescription
Enferm Infecc Microbiol Clin.
Goycochea-Valdivia WA, Baquero-Artigao F, Del Rosal T, Frick MA, Rojo P, Echeverría MJ, Noguera-Julian A, Bringué X, Saavedra-Lozano J, Vives-Oñós I, Moliner E, Cilleruelo MJ, Cuadrado I, Colino E, Castells L, Tagarro A, Vilas J, Soler-Palacin P, Blázquez-Gamero D; Spanish Registry of Infants with Congenital Cytomegalovirus Infection (REDICCMV) Study Group.
Cytomegalovirus DNA Detection by Polymerase Chain Reaction in Cerebrospinal Fluid of Infants With Congenital Infection: Associations With Clinical Evaluation at Birth and Implications for Follow-up.
Clin Infect Dis.
Saul A, O'Brien KL. Participants: Seth Berkley, Ralf Clemens, Akira Homma, Andrew Pollard, Orin Levine, Steve Black, Walter Goycochea, Isabelle Munyangaju, Monica Moschioni.
Prioritizing vaccines for developing world diseases.
Vaccine.
Kontturi A, Santiago B, Tebruegge M, von Both U, Salo E, Ritz N; Blázquez D, Bogyi M, Buonsenso D, Dreesman A, Krivec U, Mouchet F, Nejat S, Neth O, Pavić I, Ruga E, Schlags R, Soriano-Arandes A, Thee S, Tsolia M, Velizarova S.Ptbnet BCG shortage project collaborators, on behalf of the Paediatric Tuberculosis Network European Trials Group (ptbnet).
The impact of Bacille Calmette-Guérin shortage on immunisation practice and policies in Europe - APaediatric Tuberculosis Network European Trials Group (ptbnet) survey.
Tuberculosis (Edinb).
Benavides-Nieto M, Olbrich P, Obando-Santaella I, Falcón-Neyra L, Neth O, González-Galán V, Luque R.
Congenital Tuberculosis Due to Confirmed Mycobacterium caprae.
Pediatr Infect Dis J
Gijón M, Bellusci M, Petraitiene B, Noguera-Julian A, Zilinskaite V, Sanchez Moreno P, Saavedra-Lozano J, Glikman D, Daskalaki M, Kaiser-Labusch P, Falup-Pecurariu O, Montagnani C, Prieto L, Gené A, Trumpulyte G, Kulecnikova I, Lepe JA, Cercenado E, Kudinsky R, Makri A, Huppertz HI, Bleotu L, Cocchi P, García-Hierro P, Vitkauskiene A, Fortuny C, Zukovskaja V, Neth O, Santos M, Rokney A, Petra M, Lixandru R, Galli L, Guillén S, Chaves F, Rojo Conejo P.
Factors associated with severity in invasive community-acquired Staphylococcus aureus infections in children: a prospective European multicentre study.
Clin Microbiol Infect.
Calvo C, Núñez E, Camacho M, Clemente D, Fernández-Cooke E, Alcobendas R, Mayol L, Soler-Palacín P, Oscoz M, Saavedra-Lozano J, Collaborative Group.
Epidemiology and Management of Acute, Uncomplicated Septic Arthritis and Osteomyelitis: Spanish Multicenter Study.
Pediatr Infect Dis J.
Calvo I, Antón J, López Robledillo JC, de Inocencio J, Gamir ML, Merino R, Lacruz L, Camacho M, Rua MJ, Bustabad S, Díaz Cordovés-Rego G.
[Recommendations for the use of methotrexate in patients with juvenile idiopathic arthritis].
Anales de pediatría (Barcelona, Spain).
. de Felipe B, Olbrich P, Lucenas JM, Delgado-Pecellin C, Pavon-Delgado A, Marquez J, Salamanca C, Soler-Palacín P, González-Granado LI, Antolín LF, Borte S, Neth O.
Prospective neonatal screening for severe T- and B-lymphocyte deficiencies in Seville.
Pediatr Allergy Immunol.
Deyà-Martínez À, Fortuny C, Soler-Palacín P, Neth O, Sánchez E, Martín-Nalda A, Falcón-Neyra L, Vila A, Valls A, Noguera-Julián A.
Cystatin C: A Marker for Inflammation and Renal Function Among HIV-infected Children and Adolescents.
Pediatr Infect Dis J
Espiau M, Yeste D, Noguera-Julián A, González-Tomé MI, Falcón-Neyra L, Gavilán C, Navarro-Gómez ML, Mellado-Peña MJ, Gracia-Casanova M, Colino-Gil ME, Méndez M, Ciria Calavia LM, Fortuny C, Carrascosa A, Soler-Palacín P, CoRISpe-MetS Working Group.
Metabolic Syndrome in Children and Adolescents Living with HIV.
The Pediatric infectious disease journal.
Falcón-Neyra L, Palladino C, Navarro Gómez ML, Soler-Palacín P, González-Tomé MI, De Ory SJ, Frick MA, Fortuny C, Noguera-Julián A, Moreno EB, Santos JL, Olbrich P, López-Cortés LF, Briz V, Neth O, CoRISpe working group.
Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients: A multicenter study.
Medicine (Baltimore).
Hurtado Mingo A, Madruga Garrido M, Neth O, Obando I.
[Unusual complication in a paediatric patient: Wernicke encephalopathy associated with thiamine-deficient parenteral nutrition].
Neurologia (Barcelona, Spain).
Olbrich P, Falcón-Neyra L, Molinos-Quintana A, Agüero-Sánchez M, Neth O.
First Documented Case of Influenza A (H3N2 Subtype) Infection in a Patient With Complete Interferon Gamma Receptor 1 Deficiency: A Call for Systemic Vaccination Strategies.
Pediatr Infect Dis J.
. Olbrich P, Lorenz M, Cura Daball P, Lucena JM, Rensing-Ehl A, Sánchez B, Führer M, Camacho-Lovillo M, Melón M, Schwarz K, Neth O, Speckmann C.
Activated PI3Kδ syndrome type 2: Two patients, a novel mutation, and review of the literature.
Pediatric allergy and immunology.
Toscano MG, Muñoz P, Sánchez-Gilabert A, Cobo M, Benabdellah K, Anderson P, Ramos-Mejía V, Real PJ, Neth O, Molinos-Quintana A, Gregory PD, Holmes MC, Martin F.
Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell Model.T
Mol Ther.
Jiménez Varo I, González Lavandeira M, Huesa Andrade M, Falcón Neyra MD, García García E.
Kocher-Debré-Semelaigne's syndrome: A case report.
Endocrinol Nutr.