Liver, Digestive and Inflammatory Diseases

Cirugía oncológica. Terapia celular y trasplante de órganos

Francisco Javier Padillo Ruiz
Francisco Javier Padillo Ruiz
IBiS
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n
41013 - Sevilla

Laboratory: 209
Jordi Muntané Relat
Jordi Muntané Relat
IBiS
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla
Laboratory: 209
Fernando De la Portilla
Fernando De la Portilla

Francisco Javier Padillo Ruiz

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  1. Group members
  2. Research areas
  3. Publications

Group: Cirugía oncológica. Terapia celular y trasplante de órganos

Directory
Group members Cirugía oncológica. Terapia celular y trasplante de órganos
  • Álamo Martínez, José María.MD/PhD. Faculty Staff - Surgery (HUVR).
  • Bernal Bellido, Carmen.MD/PhD. Faculty Staff - Surgery (HUVR).
  • Calero Castro, Francisco José.Ingeniero de la Salud
  • Cepeda Franco, Carmen.Doctora en Medicina y Cirugía
  • De la Portilla, Fernando.
  • Flores Campos, Rocío del Carmen.Lda. en Biología
  • García Cabrera, Ana María .Doctora en Medicina y Cirugía
  • García Villasante, Natalia.Graduada en Biología
  • Gómez Bravo, Miguel Ángel.Degree in Medicine & Surgery. Faculty Staff - Surgery (HUVR).
  • Jiménez Rodríguez, Rosa María.Doctora en Medicina y Cirugía
  • Laga Boul-Atarass, Iman.Técnico.
  • Maestre Sánchez, María Victoria .Doctora en Farmacia
  • Maqueda Hernández, Mª Belén.Graduada en Ciencias Biológicas
  • Marín Gómez, Luis Miguel.Doctor of Medicine & Surgery. Researcher
  • Muntané Relat, Jordi.PhD in Biology. Researcher (Program I3-SNS).
  • Navarro Villarán, Elena.Lda. en Biología
  • Padillo Ruiz, Francisco Javier.MD/PhD. Head of Service (HUVR)
  • Pereira Arenas, Sheila.Degree in Biology. Technician.
  • Pintor Tortolero, José.FEA HUVR Dr. en Medicina
  • Ramallo Solís, Irene Mª.Doctora en Medicina y Cirugía
  • Reyes Díaz, Mª Luisa.Lda. en Medicina
  • Rubio Dorado, Mercedes.Lda. en Medicina y Cirugía
  • Silva Hucha, Silvia .Doctora en Biomedicina
  • Suarez Artacho, Gonzalo.Degree in Medicine & Surgery. Faculty Staff - Surgery (HUVR).
  • Tinoco González, José.Degree in Medicine & Surgery. Resident (HUVR).
  • Vázquez Monchul, Jorge Manuel .Doctor en Medicina y Cirugía

Research areas

The scientific activity of our group is related to three main projects:

  • Genetic and functional characterization of pancreatic cancer. Clinical studies and experimental models.
    The project investigates the involvement of PTEN/PI3K/AKT/mTOR-dependent cell signaling in pancreatic cancer. Different experimental strategies such as cell culture and the xenograft mouse model are used to assess Ras-dependent signaling involved in the induction and progression of pancreatic cancer. The effect of different inhibitors is being investigated as therapy against the neoplasic activity of pancreatic tumor cells.
  • Cell death/proliferation in hepatocarcinoma.
    Research in this area includes the regulation of cell death and proliferation signaling mediated by TNF-R1, CD95 and Trail-R receptors during the induction and progression of liver cancer. In particular, the role of oxidative and nitrosative stress on the caveolae assembling of these receptors in the plasma membrane of hepatocytes, and its functional repercussion in cell and proliferation processes is being determined, as well as in other relevant aspects of cancer progression such as invasiveness and the metastatic capacity of liver cancer cells.
  • Hepatic regeneration mediated by stem cell infusion in the liver. Clinical studies and experimental models.
    This research area evaluates the repercussion of hematopoietic stem cell infusion in patients who have undergone liver resection. Different clinical parameters of tissue regeneration, as well as the presence of tissue and cellular markers in liver and peripheral blood related to hepatocellular differentiation are being determined. In this sense, different pluripotent cell populations are being characterized according to the presence of markers related to their pluripotency or the degree of cellular/tissue differentiation.
International Journals
Sousa, JM; Barrera, L; Gomez-Bravo, MA; Nunez-Roldan, A; Aguilera, I
Glutathione S-Transferase T1 Mismatch Is a Risk Factor for Chronic Ductopenic Rejection of Liver Allografts
LIVER TRANSPLANTATION
Arteaga, AS; Aguilar, LT; Gonzalez, JT; Boza, AS; Munoz-Cruzado, VD; Ciuro, FP; Ruiz, JP
Impact of frailty in surgical emergencies. A comparison of four frailty scales
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
Pintor-Tortolero, J; Martinez-Nunez, S; Tallon-Aguilar, L; Padillo-Ruiz, FJ
Colonic intussusception caused by giant lipoma: a rare cause of bowel obstruction
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
Suarez-Grau, JM; Chaves, CR; Morales-Conde, S; Garcia, CM; Durantez, FD; Ruiz, FJP
Could we reduce adhesions to the intra-abdominal mesh in the first week? Experimental study with different methods of fixation
HERNIA
Sanchez-Arteaga, A; Tallon-Aguilar, L; Tinoco-Gonzalez, J; Del-Pozo, EP; Navas-Cuellar, A; Padillo-Ruiz, J
Use of polyvinylidene fluoride (PVDF) meshes for ventral hernia repair in emergency surgery
HERNIA
Blazquez, MJP; Vargas, DR; Ferrer, MG; Gonzalez, JT; Serrano, BV
Torsion of wandering spleen: radiological findings
EMERGENCY RADIOLOGY
Velasco, R; Mercadal, S; Vidal, N; Alana, M; Barcelo, MI; Ibanez-Julia, MJ; Bobillo, S; Agud, RC; Molina, EG; Martinez, P; Cacabelos, P; Muntanola, A; Garcia-Catalan, G; Sancho, JM; Camro, I; Lado, T; Erro, ME; Gomez-Vicente, L; Salar, A; Caballero, AC; Sole-Rodriguez, M; Perez-Larraya, JG; Huertas, N; Estela, J; Baron, M; Barbero-Bordallo, N; Encuentra, M; Dlouhy, I; Bruna, J; Graus, F
Diagnostic delay and outcome in immunocompetent patients with primary central nervous system lymphoma in Spain: a multicentric study
JOURNAL OF NEURO-ONCOLOGY
de la Portilla, F; Jimenez-Salido, A; Araujo-Miguez, A; Maestre-Sanchez, MV; Reyes-Diaz, ML; Ramallo-Solis, I; Ramos-Fernandez, M; Vazquez-Monchul, JM; Garcia-Cabrera, AM; Jimenez-Rodriguez, RM; Diaz-Pavon, JM; Padillo-Ruiz, FJ
Autologous Platelet-Rich Plasma in the Treatment of Perianal Fistula in Crohn's Disease
JOURNAL OF GASTROINTESTINAL SURGERY
Vera, R; Gonzalez-Flores, E; Rubio, C; Urbano, J; Camps, MV; Ciampi-Dopazo, JJ; Rincon, JO; Macias, VM; Braco, MAG; Suarez-Artacho, G
Multidisciplinary management of liver metastases in patients with colorectal cancer: a consensus of SEOM, AEC, SEOR, SERVEI, and SEMNIM
CLINICAL & TRANSLATIONAL ONCOLOGY
Rodriguez-Hernandez, MA; de la Cruz-Ojeda, P; Gallego, P; Navarro-Villaran, E; Stankova, P; Del Campo, JA; Kucera, O; Elkalaf, M; Maseko, TE; Cervinkova, Z; Muntane, J
Dose-dependent regulation of mitochondria' function and cell death pathway by sorafenib in liver cancer cells
BIOCHEMICAL PHARMACOLOGY
Dorado, MRM; Diaz, VP; Alberdi, MF; Ruiz, JP; Martinez, JMM
Sagliker Syndrome
CIRUGIA ESPANOLA
Tunon, JMC; Gomez, LMM; Artacho, GS; Franco, CC; Bellido, CB; Martinez, JMA; Ruiz, FJP; Bravo, MAG
Risk Factors for No Valid Liver Graft. Multivariate Study Based on the Variables Included in the Donation Protocol of the National Trasplant Organisation
CIRUGIA ESPANOLA
Ruiz, JMO; Dos Subira, L; Garcia, AG; Soriano, JR; Alonso, PA; Gallego, P
Adult congenital heart disease in Spain: health care structure and activity, and clinical characteristics
REVISTA ESPANOLA DE CARDIOLOGIA
Rodriguez-Hernandez, MA; de la Cruz-Ojeda, P; Lopez-Grueso, MJ; Navarro-Villaran, E; Requejo-Aguilar, R; Castejon-Vega, B; Negrete, M; Gallego, P; Vega-Ochoa, A; Victor, MV; Cordero, MD; Del Campo, JA; Barcena, JA; Padilla, CA; Muntane, J
Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer
REDOX BIOLOGY
Apostolova, N; Iannantuoni, F; Gruevska, A; Muntane, J; Rocha, M; Victor, VM
Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions
REDOX BIOLOGY
REDOX BIOLOGY Gonzalez, R; Rodriguez-Hernandez, MA; Negrete, M; Ranguelova, K; Rossin, A; Choya-Foces, C; de la Cruz-Ojeda, P; Miranda-Vizuete, A; Martinez-Ruiz, A; Rius-Perez, S; Sastre, J; Barcena, JA; Hueber, AO; Padilla, CA; Muntane, J
Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer
Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome
Rocha, M; Apostolova, N; Diaz-Rua, R; Muntane, J; Victor, VM
Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Miranda, PB; Artacho, GS; Bellido, CB; Gomez, LMM; Franco, CC; Martinez, JMA; Ruiz, FJP; Bravo, MAG
Management of Large, Spontaneous Portosystemic Shunts in Liver Transplantation: Case Report and Review of Literature
TRANSPLANTATION PROCEEDINGS
Abdo-Cuza, AA; Gomez-Bravo, MA; Perez-Bernal, JB; Suarez-Lopez, J; Gomez-Peire, F; Leiva-Torres, JL; Bejerano-Gil, N; Leal-Alpizar, G; Espinosa-Nodarse, N; Castellanos-Gutierrez, R
Health Care-Associated Infection in Solid Organ Transplant Recipients
TRANSPLANTATION PROCEEDINGS
Rodriguez-Hernandez, MA; Chapresto-Garzon, R; Cadenas, M; Navarro-Villaran, E; Negrete, M; Gomez-Bravo, MA; Victor, VM; Padillo, FJ; Muntane, J
Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells
CELL DEATH & DISEASE
Munoz-Cruzado, VD; Castro, FJC; Eguia, AP; Aguilar, LT; Gonzalez, JT; Puyana, JC; Ciuro, FP; Padillo-Ruiz, J
Using a bio-scanner and 3D printing to create an innovative custom made approach for the management of complex entero-atmospheric fistulas
SCIENTIFIC REPORTS
Marin-Aguilar, F; Castejon-Vega, B; Alcocer-Gomez, E; Lendines-Cordero, D; Cooper, MA; de la Cruz, P; Andujar-Pulido, E; Perez-Alegre, M; Muntane, J; Perez-Pulido, AJ; Ryffel, B; Robertson, AAB; Ruiz-Cabello, J; Bullon, P; Cordero, MD
NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPAR alpha Activity
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Pintor-Tortolero, J; Gomez-Infante, M; Duran, M; Briceno, J
Urgent laparoscopic mesh repair of a giant incarcerated Morgagni hernia - a video vignette
COLORECTAL DISEASE
Gallego, P; Oliver, JM
Medical therapy for heart failure in adult congenital heart disease: does it work?
HEART
Arroyo-Martinez, Q; Gonzalez-de Pedro, C; Perea-del Pozo, E; Martinez-Nunez, S; Padillo-Ruiz, FJ; De la Portilla-de Juan, F
Urgent care practice in anorectal abscess. Still a pending task
CIRUGIA Y CIRUJANOS
Humbert, M; Moran, M; de la Cruz-Ojeda, P; Muntane, J; Wiedmer, T; Apostolova, N; McKenna, SL; Velasco, G; Balduini, W; Eckhart, L; Janji, B; Sampaio-Marques, B; Ludovico, P; Zerovnik, E; Langer, R; Perren, A; Engedal, N; Tschan, MP
Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
BIOLOGY-BASEL
Gallego, P; Castejon-Vega, B; del Campo, JA; Cordero, MD
The Absence of NLRP3-inflammasome Modulates Hepatic Fibrosis Progression, Lipid Metabolism, and Inflammation in KO NLRP3 Mice during Aging
CELLS
Aguado-Domínguez E, Gómez L, Sousa JM, Gómez-Bravo MÁ, Núñez-Roldán A, Aguilera I.
Identification of the cellular components involved in de novo immune hepatitis: a quantitative immunohistochemical analysis
J Transl Med.
Aller R, Fernández-Rodríguez C, Lo Iacono O, Bañares R, Abad J, Carrión JA, García-Monzón C, Caballería J, Berenguer M, Rodríguez-Perálvarez M, Miranda JL, Vilar-Gómez E, Crespo J, García-Cortés M, Reig M, Navarro JM, Gallego R, Genescà J, Arias-Loste MT, Pareja MJ, Albillos A, Muntané J, Jorquera F, Solà E, Hernández-Guerra M, Rojo MÁ, Salmerón J, Caballería L, Diago M, Molina E, Bataller R, Romero-Gómez M.
Consensus document. Management of non-alcoholic fatty liver disease (NAFLD). Clinical practice guideline.
Gastroenterol Hepatol.
Arroyo-Martínez Q, Han WH, Eom BW, Yoon HM, Kim YI, Cho SJ, Lee JY, Kim CG, Morales-Conde S, Padillo-Ruiz J, Kook MC, Choi IJ, Kim YW, Ryu KW.
The distribution pattern of metastatic lymph nodes after non-curative endoscopic resection in early gastric cancer.
J Surg Oncol
Banales JM, Iñarrairaegui M, Arbelaiz A, Milkiewicz P, Muntané J, Muñoz-Bellvis L, La Casta A, González LM, Arretxe E, Alonso C, Martínez-Arranz I, Lapitz A, Santos-Laso A, Ávila MA, Martínez-Chantar ML, Bujanda L, Marín JJG, Sangro B, Macías RIR.
Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis.
Hepatology
Barranco A, Morales-Conde S, Padillo FJ.
Single port-assisted laparoscopic sleeve gastrectomy: a new approach to the growth of reproducibility of the single portretain-->.
Surg Obes Relat Dis.
Bernal Bellido C, Suárez Artacho G, Álamo Martínez JM, Marín Gómez LM, Cepeda Franco C, Barrera Pulido L, Praena Fernández JM, Padillo Ruiz J, Gómez Bravo MÁ.
Incidence and survival rate of de novo tumors in liver transplants.
Cir Esp.
de la Portilla F, Yuste Y, Pereira S, Olano C, Maestre MV, Padillo FJ.
Local Mesenchymal Stem Cell Therapy in Experimentally Induced Colitis in the Rat.
Int J Stem Cells
Del Campo JA, García-Valdecasas M, Gil-Gómez A, Rojas Á, Gallego P, Ampuero J, Gallego-Durán R, Pastor H, Grande L, Padillo FJ, Muntané J, Romero-Gómez M.
Simvastatin and metformin inhibited cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy.
PLoS One
Dios-Barbeito S, Domínguez-Bastante M, Moreno-Navas A, León-Díaz FJ, Fundora-Suárez Y, Briceño-Delgado FJ, Pitarch-Martínez M, Gómez-Bravo MÁ.
Multicentric Study of the Andalusian Experience in Polycystic Liver Disease as Indication for Liver Transplantation
Transplant Proc.
Dios-Barbeito S, Durán-Muñoz-Cruzado V, Martín-García C, Rubio-Manzanares-Dorado M, Padillo-Ruiz FJ, Pareja-Ciuró F.
Which multi-trauma patients benefit from performing a total-body CT?
Med Intensiva
Gómez-Bravo MA, Apellaniz-Ruiz M, Salcedo M, Fondevila C, Suárez F, Castellote J, Rufián S, Pons JA, Bilbao I, Álamo JM, Millán O, Brunet M, Rodríguez-Antona C.
Influence of donor liver CYP3A4*20 loss-of-function genotype on tacrolimus pharmacokinetics in transplanted patients.
Pharmacogenet Genomics.
González R, Molina-Ruiz FJ, Bárcena JA, Padilla CA, Muntané J.
Regulation of Cell Survival, Apoptosis, and Epithelial-to-Mesenchymal Transition by Nitric Oxide-Dependent Post-Translational Modifications
Antioxid Redox Signal.
Herrero JI, Cuervas-Mons V, Gómez-Bravo MÁ, Fabregat J, Otero A, Bilbao I, Salcedo MM, González-Diéguez ML, Fernández JR, Serrano MT, Jiménez M, Rodrigo JM, Narváez I, Sánchez G.
Prevalence and progression of chronic kidney disease after liver transplant: a prospective, real-life, observational, two-year multicenter study.
Rev Esp Enferm Dig.
Herrero JI, Panizo C.
Post-transplant lymphoproliferative disease after liver transplantation
Rev Esp Enferm Dig.
Macías RIR, Banales JM, Sangro B, Muntané J, Ávila MA, Lozano E, Perugorria MJ, Padillo FJ, Bujanda L, Marín JJG.
The search for novel diagnostic and prognostic biomarkers in cholangiocarcinoma
Biochim Biophys Acta Mol Basis Dis.
Marambio A, Tuñon JMC, Gómez LMM, Martínez JMA, Bellido CB, Artacho GS, Franco CC, Pulido LB, Ruiz FJP, Bravo MAG.
Intraoperative Portal Vein Flow > 123 mL/min Per 100 g Predicts a Better Survival of Patients After Liver Transplantation.
Transplant Proc
. Martín-Rodríguez A, Pérez-San-Gregorio MÁ, Avargues-Navarro ML, Borda-Mas M, Pérez-Bernal J, Gómez-Bravo MÁ.
How Thinking About the Donor Influences Post-traumatic Growth in Liver Transplant Recipients.
Transplant Proc.
Pardo F, Pons JA, Castells L, Colmenero J, Gómez MÁ, Lladó L, Pérez B, Prieto M, Briceño J.
VI consensus document by the Spanish Liver Transplantation Society
Cir Esp
Pardo F, Pons JA, Castells L, Colmenero J, Gómez MÁ, Lladó L, Pérez B, Prieto M, Briceño J.
VI consensus document by the Spanish Liver Transplantation Society
Gastroenterol Hepatol.
Pérez-San-Gregorio MÁ, Martín-Rodríguez A, Borda-Mas M, Avargues-Navarro ML, Pérez-Bernal J, Gómez-Bravo MÁ.
Family Caregivers of Liver Transplant Recipients: Coping Strategies Associated With Different Levels of Post-traumatic Growth.
Transplant Proc
Pérez-San-Gregorio MÁ, Martín-Rodríguez A, Sánchez-Martín M, Borda-Mas M, Avargues-Navarro ML, Gómez-Bravo MÁ, Conrad R.
Spanish Adaptation and Validation of the Transplant Effects Questionnaire (TxEQ-Spanish) in Liver Transplant Recipients and Its Relationship to Posttraumatic Growth and Quality of Life.
Front Psychiatry.
Pommergaard HC, Rostved AA, Adam R, Thygesen LC, Salizzoni M, Gómez Bravo MA, Cherqui D, De Simone P, Boudjema K, Mazzaferro V, Soubrane O, García-Valdecasas JC, Fabregat Prous J, Pinna AD, O'Grady J, Karam V, Duvoux C, Rasmussen A, European Liver and Intestine Transplant Association (ELITA).
Locoregional treatments before liver transplantation for hepatocellular carcinoma: a study from the European Liver Transplant Registry.
Transpl Int.
Rada P, Pardo V, Mobasher MA, García-Martínez I, Ruiz L, González-Rodríguez Á, Sánchez-Ramos C, Muntané J, Alemany S, James LP, Simpson KJ, Monsalve M, Valdecantos MP, Valverde ÁM.
SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress.
Antioxid Redox Signal.
. Rodríguez-Hernández MA, González R, de la Rosa ÁJ, Gallego P, Ordóñez R, Navarro-Villarán E, Contreras L, Rodríguez-Arribas M, González-Gallego J, Álamo-Martínez JM, Marín-Gómez LM, Del Campo JA, Quiles JL, Fuentes JM, de la Cruz J, Mauriz JL, Padillo FJ, Muntané J.
Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells
J Cell Physiol.
Rodríguez-Perálvarez M, Guerrero M, Barrera L, Ferrín G, Álamo JM, Ayllón MD, Artacho GS, Montero JL, Briceño J, Bernal C, Padillo J, Marín-Gómez LM, Pascasio JM, Poyato A, Gómez-Bravo MA, De la Mata M.
Impact of Early Initiated Everolimus on the Recurrence of Hepatocellular Carcinoma After Liver Transplantation.
Transplantation.
Rovira-Llopis S, Apostolova N, Bañuls C, Muntané J, Rocha M, Victor VM.
Mitochondria, the NLRP3 Inflammasomes, and Sirtuins in Type 2 Diabetes: New Therapeutic Targets.
Antioxid Redox Signal.
Rubio-Manzanares Dorado M, Marín Gómez LM, Aparicio Sánchez D, Pereira Arenas S, Praena-Fernández JM, Borrero Martín JJ, Farfán López F, Gómez Bravo MÁ, Muntané Relat J, Padillo Ruiz J.
Translational pancreatic cancer research: A comparative study on patient-derived xenograft models.
World J Gastroenterol.
Tallón-Aguilar L, López-Ruiz JA, Domínguez-Sánchez C, Pareja-Ciuró F, Padillo-Ruiz J.
Laparoscopic approach in post-traumatic chylous ascites.
Ann R Coll Surg Engl.
Tinoco González J, Álamo Martínez JM, Bernal Bellido C, Suárez Artacho G, Marín Gómez LM, Barrera-Pulido L, Padillo Ruíz J, Gómez Bravo MÁ.
1000 consecutive liver transplants. Descriptive analysis and evolution of a single center.
Cir Esp.
Books and articles in books
García Cabrera AM, Jiménez Rodríguez RM, Reyes Díaz ML, Vázquez Monchul JM, Ramos Fernández M, Díaz Pavón JM, Palacios González C, Padillo Ruiz FJ, de la Portilla de Juan F.
Fecal incontinence in older patients. A narrative review.
Cir Esp.
Pommergaard HC, Rostved AA, Adam R, Thygesen LC, Salizzoni M, Gómez Bravo MA, Cherqui D, Filipponi F, Boudjema K, Mazzaferro V, Soubrane O, García-Valdecasas JC, Prous JF, Pinna AD, O'Grady J, Karam V, Duvoux C, Rasmussen A, European Liver and Intestine Transplant Association (ELITA).
Vascular invasion and survival after liver transplantation for hepatocellular carcinoma: a study from the European Liver Transplant Registry.
HPB (Oxford).