Oncohematología y Genética

Expresión Génica

Sebastián Chávez de Diego
Sebastián Chávez de Diego
IBiS
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla
Laboratorio: 201
Fernando Gómez Herreros
Fernando Gómez Herreros

Sebastián Chávez de Diego

Volver al programa
  1. Miembros del grupo
  2. Áreas de trabajo
  3. Publicaciones

Grupo: Expresión Génica

Directorio
Miembros del grupo Expresión Génica
  • Chávez de Diego, Sebastián.Investigador Responsable
  • Delgado Román, Irene.Investigadora en Formación. Plan Propio US.
  • Fontalva Ostio, Sara.Lda. en Biología
  • Gómez Herreros, Fernando.Investigador Ramón y Cajal, US. Doctor en Biología
  • Granado de la Calle, Esperanza Lisha.Lda. en Biotecnología
  • Muñoz Centeno, María de la Cruz.Profesora Titular de Genética de la Universidad de Sevilla. Doctora en Biología
  • Peñate Salas, Xenia.Posdoctoral, Doctora en Biología
  • Rubio Contreras, Diana.Investigadora en Formación

Áreas de trabajo

  • Mecanismos moleculares de expresión del genoma 
  • Funciones de la prefoldina en el núcleo celular 
  • Heterogeneidad replicativa de poblaciones celulares 
  • Expresión génica, reparación de DNA y enfermedad 
Revistas Internacionales
Begley, V; Jordan-Pla, A; Penate, X; Garrido-Godino, AI; Challal, D; Cuevas-Bermudez, A; Mitjavila, A; Barucco, M; Gutierrez, G; Singh, A; Alepuz, P; Navarro, F; Libri, D; Perez-Ortin, JE; Chavez, S
Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configuration
RNA BIOLOGY
Olmedo-Pelayo, J; Rubio-Contreras, D; Gomez-Herreros, F
Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity
NUCLEIC ACIDS RESEARCH
Penate, X; Praena-Fernandez, JM; Pareja, PR; Enguix-Riego, MD; Payan-Bravo, L; Vieites, B; Gomez-Izquierdo, L; Olasolo, JJ; del Campo, ER; Reyes, JC; Chavez, S; Lopez Guerra, JL
Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer
CANCERS
Begley V, Corzo D, Jordán-Pla A, Cuevas-Bermúdez A, Miguel-Jiménez L, Pérez-Aguado D, Machuca-Ostos M, Navarro F, Chávez MJ, Pérez-Ortín JE, Chávez S
The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4.
Nucleic Acids Res.
Pérez-Ortín JE, Tordera V, Chávez S
Homeostasis in the Central Dogma of molecular biology: the importance of mRNA instability.
RNA Biol.
Ramos-Sáenz A, González-Álvarez D, Rodríguez-Galán O, Rodríguez-Gil A, Gaspar SG, Villalobo E, Dosil M, de la Cruz J
Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae.
RNA.
Gómez-Herreros F
DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II.
Front Mol Biosci.
Martinez-Macias MI, Moore DA, Green RL, Gomez-Herreros F, Naumann M, Hermann A, Van Damme P, Hafezparast M, Caldecott KW
FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress.
Life Sci Alliance
Maya Miles D, Peñate X, Sanmartín Olmo T, Jourquin F, Muñoz Centeno MC, Mendoza M, Simon MN, Chavez S, Geli V
High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1.
eLife 7. pii: e35337. doi: 10.7554/eLife.35337.
de la Cruz J, Gómez-Herreros F, Rodríguez-Galán O, Begley V, de la Cruz Muñoz-Centeno M, Chávez S
Feedback regulation of ribosome assembly.
Current Genetics. 64:393-404. doi: 10.1007/s00294-017-0764-x.
Martínez-Fernández V, Garrido-Godino AI, Mirón-García MC, Begley V, Fernández-Pévida A, de la Cruz J, Chávez S, Navarro F
Rpb5 modulates the RNA polymerase II transition from initiation to elongation by influencing Spt5 association and backtracking.
Biochim Biophys Acta 1861:1-13. doi: 10.1016/j.bbagrm.2017.11.002.
de la Cruz J, Gómez-Herreros F, Rodríguez-Galán O, Begley V, de la Cruz Muñoz-Centeno M, Chávez S.
Feedback regulation of ribosome assembly.
Curr Genet
Martínez-Fernández V, Garrido-Godino AI, Mirón-García MC, Begley V, Fernández-Pévida A, de la Cruz J, Chávez S, Navarro F.
Rpb5 modulates the RNA polymerase II transition from initiation to elongation by influencing Spt5 association and backtracking.
Biochim Biophys Acta Gene Regul Mech
Maya Miles D, Peñate X, Sanmartín Olmo T, Jourquin F, Muñoz Centeno MC, Mendoza M, Simón MN, Chávez S, Geli V.
High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1
Elife
Gómez-Herreros F, Zagnoli-Vieira G, Ntai I, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A, Caldecott KW
TDP2 suppresses chromosomal
Nature Communications 8:233. doi: 10.1038/s41467-017-00307-y.
Gutiérrez G, Millán-Zambrano G, Medina DA, Jordán-Pla A, Pérez-Ortín JE, Peñate X, Chávez S
Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning.
Epigenetics and Chromatin. 10:58. doi: 10.1186/s13072-017-0165-x.
Silva A, Cavero S, Begley V, Solé C, Böttcher R, Chávez S, Posas F, de Nadal E
Regulation of transcription elongation in response to osmostress.
PLoS Genetics 13(11):e1007090. doi: 10.1371/journal.pgen.1007090.
Gómez-Herreros F, Margaritis T, Rodríguez-Galán O, Pelechano V, Begley V, Millán-Zambrano G, Morillo-Huesca M, Muñoz-Centeno MC, Pérez-Ortín JE, de la Cruz J, Holstege FCP, Chávez S
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation.
Nucleic Acids Research. 45:9302-9318. doi: 10.1093/nar/gkx529.
Asymmetric cell division requires specific mechanisms for adjusting global transcription.
Mena A, Medina DA, García-Martínez J, Begley V, Singh A, Chávez S, Muñoz-Centeno MC, Pérez-Ortín JE
Nucleic Acids Research. 45:12401-12412. doi: 10.1093/nar/gkx974.
Espinar-Marchena FJ, Babiano R, de la Cruz J.
Placeholder factors in ribosome biogenesis: please, pave my way.
Microb Cell.
Gómez-Herreros F, Margaritis T, Rodríguez-Galán O, Pelechano V, Begley V, Millán-Zambrano G, Morillo-Huesca M, Muñoz-Centeno MC, Pérez-Ortín JE, de la Cruz J, Holstege FCP, Chávez S.
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation.
Nucleic Acids Res.
Gómez-Herreros F, Zagnoli-Vieira G, Ntai I, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A, Caldecott KW.
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.
Nat Commun
Mena A, Medina DA, García-Martínez J, Begley V, Singh A, Chávez S, Muñoz-Centeno MC, Pérez-Ortín JE.
Asymmetric cell division requires specific mechanisms for adjusting global transcription
Nucleic Acids Res.
Silva A, Cavero S, Begley V, Solé C, Böttcher R, Chávez S, Posas F, de Nadal E.
Regulation of transcription elongation in response to osmostress.
PLoS Genet.
Gutiérrez G, Millán-Zambrano G, Medina DA, Jordán-Pla A, Pérez-Ortín JE, Peñate X, Chávez S.
Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning.
Epigenetics Chromatin
Chávez S, García-Martínez J, Delgado-Ramos L, Pérez-Ortín JE
The importance of controlling mRNA turnover during cell proliferation.
Current Genetics. 62:701-710. Doi: 10.1007/s00294-016-0594-2
García-Martínez J, Delgado-Ramos L, Ayala G, Pelechano V, Medina DA, Carrasco F, González R, Andrés-León E, Steinmetz L, Warringer J, Chávez S, Pérez-Ortín JE
The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons.
Nucleic Acids Research 44:3643-3658. doi: 10.1093/nar/gkv1512.
García-Martínez J, Troulé K, Chávez S, Pérez-Ortín JE
Growth rate controls mRNA turnover in steady and non-steady states.
RNA Biology 13:1175-1181. doi: 10.1080/15476286.2016.1236171
Chávez S and Puerto-Camacho P
Prefoldins
The Encyclopaedia of Life Sciences doi: 10.1002/9780470015902.a0026334.