Oncohematología y Genética

Expresión Génica

Sebastián Chávez de Diego
IBiS
Campus Hospital Universitario Virgen del Rocío
Avda. Manuel Siurot, s/n.
41013 · Sevilla
Laboratorio: 201

Sebastián Chávez de Diego

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  1. Miembros del grupo
  2. Áreas de trabajo
  3. Publicaciones

Grupo: Expresión Génica

Directorio
Miembros del grupo Expresión Génica
  • Begley, Victoria Sarah.Dra. en Biología
  • Chávez de Diego, Sebastián.Investigador Responsable
  • de Miguel Jiménez, M Dolores.Dra. en Farmacia
  • Delgado Román, Irene.Investigadora en Formación. Plan Propio US.
  • Gómez Herreros, Fernando.Investigador Ramón y Caja, US.
  • Muñoz Centeno, María de la Cruz.Profesora Titular de Genética de la Universidad de Sevilla. Doctora en Biología
  • Payán Bravo, Laura.Lda. en Biología. Predoctoral.
  • Peñate Salas, Xenia.Posdoctoral, Doctora en Biología
  • Rubio Contreras, Diana.Investigadora en Formación

Áreas de trabajo

  • Mecanismos moleculares de expresión del genoma 
  • Funciones de la prefoldina en el núcleo celular 
  • Heterogeneidad replicativa de poblaciones celulares 
  • Expresión génica, reparación de DNA y enfermedad 
Revistas Internacionales
Maya Miles D, Peñate X, Sanmartín Olmo T, Jourquin F, Muñoz Centeno MC, Mendoza M, Simon MN, Chavez S, Geli V
High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1.
eLife 7. pii: e35337. doi: 10.7554/eLife.35337.
de la Cruz J, Gómez-Herreros F, Rodríguez-Galán O, Begley V, de la Cruz Muñoz-Centeno M, Chávez S
Feedback regulation of ribosome assembly.
Current Genetics. 64:393-404. doi: 10.1007/s00294-017-0764-x.
Martínez-Fernández V, Garrido-Godino AI, Mirón-García MC, Begley V, Fernández-Pévida A, de la Cruz J, Chávez S, Navarro F
Rpb5 modulates the RNA polymerase II transition from initiation to elongation by influencing Spt5 association and backtracking.
Biochim Biophys Acta 1861:1-13. doi: 10.1016/j.bbagrm.2017.11.002.
Gómez-Herreros F, Zagnoli-Vieira G, Ntai I, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A, Caldecott KW
TDP2 suppresses chromosomal
Nature Communications 8:233. doi: 10.1038/s41467-017-00307-y.
Gutiérrez G, Millán-Zambrano G, Medina DA, Jordán-Pla A, Pérez-Ortín JE, Peñate X, Chávez S
Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning.
Epigenetics and Chromatin. 10:58. doi: 10.1186/s13072-017-0165-x.
Silva A, Cavero S, Begley V, Solé C, Böttcher R, Chávez S, Posas F, de Nadal E
Regulation of transcription elongation in response to osmostress.
PLoS Genetics 13(11):e1007090. doi: 10.1371/journal.pgen.1007090.
Gómez-Herreros F, Margaritis T, Rodríguez-Galán O, Pelechano V, Begley V, Millán-Zambrano G, Morillo-Huesca M, Muñoz-Centeno MC, Pérez-Ortín JE, de la Cruz J, Holstege FCP, Chávez S
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation.
Nucleic Acids Research. 45:9302-9318. doi: 10.1093/nar/gkx529.
Asymmetric cell division requires specific mechanisms for adjusting global transcription.
Mena A, Medina DA, García-Martínez J, Begley V, Singh A, Chávez S, Muñoz-Centeno MC, Pérez-Ortín JE
Nucleic Acids Research. 45:12401-12412. doi: 10.1093/nar/gkx974.
Chávez S, García-Martínez J, Delgado-Ramos L, Pérez-Ortín JE
The importance of controlling mRNA turnover during cell proliferation.
Current Genetics. 62:701-710. Doi: 10.1007/s00294-016-0594-2
García-Martínez J, Delgado-Ramos L, Ayala G, Pelechano V, Medina DA, Carrasco F, González R, Andrés-León E, Steinmetz L, Warringer J, Chávez S, Pérez-Ortín JE
The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons.
Nucleic Acids Research 44:3643-3658. doi: 10.1093/nar/gkv1512.
García-Martínez J, Troulé K, Chávez S, Pérez-Ortín JE
Growth rate controls mRNA turnover in steady and non-steady states.
RNA Biology 13:1175-1181. doi: 10.1080/15476286.2016.1236171
Chávez S and Puerto-Camacho P
Prefoldins
The Encyclopaedia of Life Sciences doi: 10.1002/9780470015902.a0026334.
Jordán-Pla A, Gupta I, de Miguel-Jiménez L, Steinmetz LM, Chávez S, Pelechano V, Pérez-Ortín JE
Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle.
Nucleic Acids Research 43: 787-802. doi: 10.1093/nar/gku1349.
Nadal-Ribelles M, Mas G, Millán-Zambrano G, Solé C, Ammerer G, Chávez S, Posas F, de Nadal E
H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes
Nucleic Acids Research. 43: 4937-4949. doi: 10.1093/nar/gkv220.
González-Barrios M, Fierro-González JC, Krpelanova E, Mora-Lorca JA, Pedrajas JR, Peñate X, Chávez S, Swoboda P, Jansen G, Miranda-Vizuete A
Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans.
Genetics 200: 123-34. doi: 10.1534/genetics.115.176172.
Delgado-Ramos L, Marcos AT, Ramos-Guelfo MS, Sánchez-Barrionuevo L, Smet F, Chávez S, Cánovas D
Flow cytometry of microencapsulated colonies for genetics analysis of filamentous fungi.
G3 Genes Genomes Genetics 4: 2271-2278. doi: 10.1534/g3.114.014357.
Mirón-García MC, Garrido-Godino AI, Martínez-Fernández V, Fernández-Pevida A, Cuevas-Bermúdez A, Martín-Expósito M, Chávez S, de la Cruz J, Navarro F
The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription.
Nucleic Acids Research 42: 9666-9676. doi: 10.1093/nar/gku685.
Millán-Zambrano G, Chávez S
Nuclear functions of prefoldin
Open Biology. 4. pii: 140085. doi: 10.1098/rsob.140085
Medina DA, Jordán-Pla A, Millán-Zambrano G, Chávez S, Choder M, Pérez-Ortín JE
Cytoplasmic 5'-3' exonuclease Xrn1p is also a genome-wide transcription factor in yeast.
Frontiers in Genetics 5:1. doi: 10.3389/fgene.2014.00001.
Peñate X, Chávez S
RNA polymerase II-dependent transcription in fungi and its interplay with mRNA decay.
In “Fungal RNA Biology” A Sesma and T von der Haar (Eds), Springer. pp: 1-26 doi: 10.3389
Millán-Zambrano G, Rodríguez-Gil A, Peñate X, de Miguel-Jiménez L, Morillo-Huesca M, Krogan N, Chávez S
The Prefoldin Complex Regulates Chromatin Dynamics during Transcription Elongation.
PLoS Genetics 9: e1003776. doi: 10.1371/journal.pgen.1003776.
Haimovich G, Medina D, Causs S, Garber M, Millán-Zambrano G, Barkai O, Chávez S. Pérez-Ortín JE, Darzacq X, Choder M
Gene expresión is circular: factors for mRNA degradation also foster mRNA synthesis.
Cell 153: 1000-1011. doi: 10.1016/j.cell.2013.05.012.
Gómez-Herreros F, Rodríguez-Galán O, Morillo-Huesca M, Maya D, Arista-Romero M, de la Cruz J, Chávez S, Muñoz-Centeno MC
Balanced production of ribosome components is required for proper G1/S transition in Saccharomyces cerevisiae.
Journal of Biological Chemistry 288: 31689-31700. doi: 10.1074/jbc.M113.500488
Pérez-Ortín JE, Medina DA, Chávez S, Moreno J
What do you mean by transcription rate?: the conceptual difference between nascent transcription rate and mRNA synthesis rate is essential for the proper understanding of transcriptomic analyses.
Bioessays 35:1056-1062. doi: 10.1002/bies.201300057
Miguel A, Montón F, Li T, Gómez-Herreros F, Chávez S, Alepuz P, Pérez-Ortín JE
External conditions inversely change the RNA polymerase II elongation rate and density in yeast.
Biochim Biophys Acta 1829:1248-1255. doi: 10.1016/j.bbagrm.2013.09.008.
Pérez-Ortín JE, Alepuz P, Chávez S, Choder M
Eukaryotic mRNA decay: methodologies, pathways, and links to other stages of gene expression.
Journal of Molecular Biolology 425: 3750-3775. doi: 10.1016/j.jmb.2013.02.029.